Towards Intelligent Databases

This article is a presentation of the objectives and techniques of deductive databases. The deductive approach to databases aims at extending with intensional definitions other database paradigms that describe applications extensionaUy. We first show how constructive specifications can be expressed with deduction rules, and how normative conditions can be defined using integrity constraints. We outline the principles of bottom-up and top-down query answering procedures and present the techniques used for integrity checking. We then argue that it is often desirable to manage with a database system not only database applications, but also specifications of system components. We present such meta-level specifications and discuss their advantages over conventional approaches

Utility of Ultrasound for Imaging Osteophytes in Patients with Insertional Achilles Tendinopathy

Objectives: To examine (1) the validity of ultrasound imaging to measure osteophytes and (2) the association between osteophytes and insertional Achilles tendinopathy (IAT). Design: Case-control study. Setting: Academic medical center. Participants: Persons with chronic unilateral IAT (n=20; mean age, 58.7±8.3y; 10 [50%] women) and age- and sex-matched controls (n=20; mean age, 57.4±9.8y; 10 [50%] women) participated in this case-control study (N=40). Interventions: Not applicable. Main Outcome Measures: Symptom severity was assessed using the Foot and Ankle Ability Measure, the Victorian Institute of Sport Assessment-Achilles questionnaire, and the numerical rating scale. Length of osteophytes was measured bilaterally in both groups using ultrasound imaging, as well as on the symptomatic side of the IAT group using radiography. The intraclass correlation coefficient was used to examine the agreement between ultrasound and radiograph measures. McNemar, Wilcoxon signed-rank, and Fisher exact tests were used to compare the frequency and length of osteophytes between sides and groups. Pearson correlation was used to examine the association between osteophyte length and symptom severity. Results: There was good agreement (intraclass correlation coefficient, ≥.75) between ultrasound and radiograph osteophyte measures. There were no statistically significant differences (P\u3e.05) in the frequency of osteophytes between sides or groups. Osteophytes were larger on the symptomatic side of the IAT group than on the asymptomatic side (P=.01) and on the left side of controls (P=.03). There was no association between osteophyte length and symptom severity. Conclusions: Ultrasound imaging is a valid measure of osteophyte length, which is associated with IAT. Although a larger osteophyte indicates tendinopathy, it does not indicate more severe IAT symptoms

Multimode Dispersion Compensated Pulse-Echo Guided Wave Inspection

Obtaining temporal/spatial resolution in guided wave measurements comparable to that of bulk wave measurements is impeded by the complicating effects of multimode dispersion. Transport of signals by multiple dispersive modes of propagation can transform an initially compact transient into an extended, visually unintelligible wavetrain. Guided mode inspections therefore tend to restrict measurements to regimes for which a single mode can be generated with minimal dispersion, consequently restricting the achievable temporal/spatial resolution of the measurement. The objective of the work reported here is to remove such restrictions, through implementation of wavefield measurements which accommodate the total complexity of multimode dispersed signals. Temporal and spatial Fourier analysis of guided wave fields enables a full identification of individual mode contributions. It is therefore conceivable that, given measurements taken over an appropriate spatial array, processing could be implemented to effectively remove the effects of multimode dispersion, enabling operation in frequency regimes currently associated with bulk wave measurements. This paper will report on work which is exploring this possibility. Results will be presented demonstrating array-based MHz regime plate wave measurements, generating 10 or more modes, in which individual modes are isolated, effects of dispersion are removed, and temporal resolution of the original transmitted pulse is restored. Examples of application will be presented, and factors determining the effectiveness of temporal resolution restoration will be discussed

Prevention of Dermatologic Side Effects of Bimatoprost 0.03% Topical Therapy

PURPOSE: To investigate the efficacy of reducing the drop-skin contact to prevent dermatologic side effects of bimatoprost 0.03% topical therapy. DESIGN: Prospective, randomized, single-blinded, internally controlled study. METHODS: Enrolled subjects started bimatoprost 0.03% therapy once at night in both eyes and were instructed to wipe selectively only one eye (eye 1) with an adsorbent pad during and after drops administration for four months. The fellow eye acted as the internal control. Eyelash growth, regional skin hypertrichosis, and pigmentation on the periocular skin were assessed at baseline and during the four months of follow-up. RESULTS: A lower incidence of eyelash growth and skin pigmentation in the inferonasal pericanthal region were observed in eye 1. The incidence of pigmentation in the inferotemporal skin region and skin hypertrichosis were similar in the two eyes. CONCLUSION: The reduction of the drop,skin contact affects the regional incidence and the extent of dermatologic skin changes that are related to bimatoprost 0.03% topical therapy

MOSAIC: A Scalable reconfigurable 2D array system for NDT

This paper documents the development of a scalable 2D array system, or Mosaic that can be targeted at a wide range of NDT applications by way of a reconfigurable tile that can be tessellated to form arrays of any size and shape. Close coupling permits utilization of excitation voltages as low as +/-3.3V with insertion loss of 48dB on reflection from an aluminum back wall at 73mm achieved using 2D arrays without decoding

Sprinting Velocity Increases Through Postactivation Potentiation with a Hex-Bar Farmers Walk

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The Influence of Thin Bonding Layers on the Leaky Waves at Liquid-Solid Interfaces

This paper presents theoretical and experimental results on the problem of bounded acoustic beam reflection at the Rayleigh angle from a fluid-solid interface which is loaded by a thin solid layer. The theoretical development exploits the framework of existing theory to yield a simple, analytic model which is reasonably accurate for thin layers. It is shown that the influence of the layer is contained entirely in the dispersive Rayleigh wavespeed and the thickness-dependent displacement parameter Δs. Measurements of the reflected acoustic field amplitude have been performed on several samples of stainless steel loaded with a thin copper layer. We have found reasonably good agreement between the theoretical model calculations and experimental measurements for ratios of the layer thickness to the Rayleigh wavelength as large as 0.3. Beyond this value, some disparity is observed, particularly in the calculation of the thickness-dependent Rayleigh wavespeed

Systemic therapy of primary cutaneous B-cell lymphoma, marginal zone type, with rituximab, a chimeric anti-CD20 monoclonal antibody

[No abstract available

Bone marrow-derived cells can acquire cardiac stem cells properties in damaged heart

Experimental data suggest that cell-based therapies may be useful for cardiac regeneration following ischaemic heart disease. Bone marrow (BM) cells have been reported to contribute to tissue repair after myocardial infarction (MI) by a variety of humoural and cellular mechanisms. However, there is no direct evidence, so far, that BM cells can generate cardiac stem cells (CSCs). To investigate whether BM cells contribute to repopulate the Kit+ CSCs pool, we transplanted BM cells from transgenic mice, expressing green fluorescent protein under the control of Kit regulatory elements, into wild-type irradiated recipients. Following haematological reconstitution and MI, CSCs were cultured from cardiac explants to generate 'cardiospheres', a microtissue normally originating in vitro from CSCs. These were all green fluorescent (i.e. BM derived) and contained cells capable of initiating differentiation into cells expressing the cardiac marker Nkx2.5. These findings indicate that, at least in conditions of local acute cardiac damage, BM cells can home into the heart and give rise to cells that share properties of resident Kit+ CSCs