An exact formalism to study the thermodynamic properties of hard-sphere systems under spherical confinement

This paper presents a modified grand canonical ensemble which provides a new simple and efficient scheme to study few-body fluid-like inhomogeneous systems under confinement. The new formalism is implemented to investigate the exact thermodynamic properties of a hard sphere (HS) fluid-like system with up to three particles confined in a spherical cavity. In addition, the partition function of this system was used to analyze the surface thermodynamic properties of the many-HS system and to derive the exact curvature dependence of both the surface tension and adsorption in powers of the density. The expressions for the surface tension and the adsorption were also obtained for the many- HS system outside of a fixed hard spherical object. We used these results to derive the dependence of the fluid-substrate Tolman length up to first order in density.Comment: 6 figures. The paper includes new exact results about hard spheres fluid-like system

A hadronic scenario for HESS J1818-154

Aims: G15.4+0.1 is a faint supernova remnant (SNR) that has recently been associated with the gamma-ray source HESS J1818-154. We investigate a hadronic scenario for the production of the gamma-ray emission. Methods: Molecular 13CO (J=1-0) taken from the Galactic Ring Survey (GRS) and neutral hydrogen (HI) data from the Southern Galactic Plane Survey (SGPS) have been used in combination with new 1420 MHz radio continuum observations carried out with the Giant Metrewave Radio Telescope (GMRT). Results: From the new observations and analysis of archival data we provided for the first time a reliable estimate for the distance to the SNR G15.4+0.1 and discovered molecular clouds located at the same distance. On the basis of HI absorption features, we estimate the distance to G15.4+0.1 in 4.8+/-1.0 kpc. The 13CO observations clearly show a molecular cloud about 5 arcmin in size with two bright clumps, labeled A and B, clump A positionally associated with the location of HESS J1818-154 and clump B in coincidence with the brightest northern border of the radio SNR shell. The HI absorption and the 13CO emission study indicates a possible interaction between the molecular material and the remnant. We estimate the masses and densities of the molecular gas as (1.2+/-0.5)X10^3 M_sun and (1.5+/-0.4)X10^3 cm^-3 for clump A and (3.0+/-0.7)X10^3 M_sun and (1.1+/-0.3)X10^3 cm^-3 for clump B. Calculations show that the average density of the molecular clump A is sufficient to produce the detected gamma-ray flux, thus favoring a hadronic origin for the high-energy emission.Comment: Accepted to be published in Astronomy and Astrophysics Letter

A complete radio study of SNR G15.4+0.1 from new GMRT observations

The supernova remnant G15.4+0.1 is considered to be the possible counterpart of the gamma-ray source HESSJ1818-154. With the goal of getting a complete view of this remnant and understanding the nature of the gamma-ray flux, we conducted a detailed radio study that includes the search for pulsations and a model of the broadband emission for the G15.4+0.1/HESSJ1818-154 system. Low-frequency imaging at 624 MHz and pulsar observations at 624 and 1404 MHz towards G15.4+0.1 were carried out with the Giant Metrewave Radio Telescope (GMRT). We correlated the new radio data with observations of the source at X-ray and infrared wavelengths from XMM-Newton and Herschel observatories, respectively. To characterize the neutral hydrogen medium (HI) towards G15.4+0.1, we used data from the Southern Galactic Plane Survey. We modelled the spectral energy distribution using both hadronic and leptonic scenarios. From the combination of the new GMRT observations with existing data, we derived a continuum spectral index alpha=-0.62+-0.03 for the whole remnant. The local synchrotron spectra of G15.4+0.1, calculated from the combination of the GMRT data with 330 MHz observations from the VLA, tends to be flatter in the central part of the remnant, accompanying the region where the blast wave is impinging molecular gas. No spectral index trace was found indicating the radio counterpart to the pulsar wind nebula proposed from X-ray observations. In addition, the search for radio pulsations yielded negative results. Emission at far-infrared wavelengths is observed in the region where the SNR shock is interacting with dense molecular clumps. We also identified HI features forming a shell that wraps most of the outer border of G15.4+0.1. Characteristic parameters were estimated for the shocked HI gas. We found that either a purely hadronic or leptonic model is compatible with the broadband emission known so far.Comment: 11 pages, 9 figures, accepted for publication in Astronomy & Astrophysic

Optimisation-based refinement of genesis indices for tropical cyclones

Tropical cyclone genesis indices are valuable tools for studying the relationship between large-scale environmental fields and the genesis of tropical cyclones, supporting the identification of future trends of cyclone genesis. However, their formulation is generally derived from simple statistical models (e.g., multiple linear regression) and are not optimised globally. In this paper, we present a simple framework for optimising genesis indexes given a user-specified trade-off between two performance metrics, which measure how well an index captures the spatial and interannual variability of tropical cyclone genesis. We apply the proposed framework to the popular Emanuel and Nolan Genesis Potential Index, yielding new, optimised formulas that correspond to different trade-offs between spatial and interannual variability. Result show that our refined indexes can improve the performance of the Emanuel and Nolan index up to 8% for spatial variability and 16%-22% for interannual variability; this improvement was found to be statistically significant (p < 0.01). Lastly, by analysing the formulas found, we give some insights into the role of the different inputs of the index in maximising one metric or the other

A new study towards PSR J1826-1334 and PSR J1826-1256 in the region of HESS J1825-137 and HESS J1826-130

Aims. The goal of this paper is to detect synchrotron emission from the relic electrons of the crushed pulsar wind nebula (PWN) HESS J1825-137 and to investigate the origin of the $\gamma$-ray emission from HESS J1826-130.\\ Methods. The study of HESS J1825-137 was carried out on the basis of new radio observations centred at the position of PSR J1826-1334 performed with the Karl G. Jansky Very Large Array at 1.4 GHz in configurations B and C. To investigate the nature of HESS J1826-130, we reprocessed unpublished archival data obtained with XMM-Newton.\\ Results. The new radio continuum image towards PSR J1826-1334 reveals a bright radio source, with the pulsar located in its centre, which suggests that this feature could be the radio counterpart of the compact component of the PWN detected at high energy. The new 1.4 GHz radio data do not reveal emission with an extension comparable with that observed in $\gamma$-rays for the HESS J1825-137 source. On the other hand, the XMM-Newton study of the region including PSR J1826-1256 reveals an elongated non-thermal X-ray emitting nebula with the pulsar located in the northern border and a tail towards the peak of the very high energy source. The spectrum is characterized by a power law with a photon index going from 1.6 around the pulsar to 2.7 in the borders of the nebula, a behaviour consistent with synchrotron cooling of electrons. From our X-ray analysis we propose that HESS J1826-130 is likely produced by the PWN powered by PSR J1826-1256 via the inverse Compton mechanism.Comment: 9 pages, 5 figures, 4 tables. Accepted for publication in the Astronomy & Astrophysics Journal. The quality of the images has been degrade

Dual mTOR/PI3K inhibition limits PI3K-dependent pathways activated upon mTOR inhibition in autosomal dominant polycystic kidney disease

Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the development of kidney cysts leading to kidney failure in adulthood. Inhibition of mammalian target of rapamycin (mTOR) slows polycystic kidney disease (PKD) progression in animal models, but randomized controlled trials failed to prove efficacy of mTOR inhibitor treatment. Here, we demonstrate that treatment with mTOR inhibitors result in the removal of negative feedback loops and up-regulates pro-proliferative phosphatidylinositol 3-kinase (PI3K)-Akt and PI3K-extracellular signal-regulated kinase (ERK) signaling in rat and mouse PKD models. Dual mTOR/PI3K inhibition with NVP-BEZ235 abrogated these pro-proliferative signals and normalized kidney morphology and function by blocking proliferation and fibrosis. Our findings suggest that multi-target PI3K/mTOR inhibition may represent a potential treatment for ADPKD