On Myosin II dynamics in the presence of external loads

We address the controversial hot question concerning the validity of the loose coupling versus the lever-arm theories in the actomyosin dynamics by re-interpreting and extending the phenomenological washboard potential model proposed by some of us in a previous paper. In this new model a Brownian motion harnessing thermal energy is assumed to co-exist with the deterministic swing of the lever-arm, to yield an excellent fit of the set of data obtained by some of us on the sliding of Myosin II heads on immobilized actin filaments under various load conditions. Our theoretical arguments are complemented by accurate numerical simulations, and the robustness of the model is tested via different choices of parameters and potential profiles.Comment: 6 figures, 8 tables, to appear on Biosystem

Why did Texas have a jobless recovery?

Employment ; Immigrants ; Labor market

Is Exercise Beneficial to the Functionality of Elderly Individuals?

OBJECTIVE: The objective of this selective EBM review is to determine whether or not exercise improves the functionality of elderly individuals. STUDY DESIGN: A review of three peer-reviewed studies published between 2012 and 2018. DATA SOURCES: One unblinded randomized controlled trial, one blinded randomized control trial, and one matched-control group with randomized groups to show if exercise is beneficial to the functionality; focusing mainly on physical health, of elderly individuals. OUTCOMES MEASURED: The outcome measured in this study is the quality of life of the patients in regards to their physical health from questionnaires filled out by the participants. RESULTS: The studies conducted by Lok N et al, Langois et. al, and Janyacharoen T, et. al proved that there is a statistically significant correlation between exercise and increased functionality of elderly individuals (all p\u3c0.05). CONCLUSIONS: The results of these studies are conclusive and support the correlation of exercise and increased functionality of elderly individuals

Hepatitis C virus pharmacogenomics in Latin American populations: implications in the era of direct-acting antivirals

In recent years, great progress has been made in the field of new therapeutic options for hepatitis C virus (HCV) infection. The new direct-acting antiviral agents (DAAs) represent a great hope for millions of chronically infected individuals because their use may lead to excellent cure rates with fewer side effects. In Latin America, the high prevalence of HCV genotype 1 infection and the significant association of Native American ancestry with risk predictive single-nucleotide polymorphisms (SNPs) in IFNL4 and ITPA genes highlight the need to implement new treatment regimens in these populations. However, the universal accessibility to DAAs is still not a reality in the region as their high cost is one of the major, although not the only, limiting factors for their broad implementation. Therefore, under these circumstances, could the assessment of host genetic markers be a useful tool to prioritize DAA treatment until global access to these new drugs can be achieved? This review will summarize the scientific evidences and the potential implications of HCV pharmacogenomics in this rapidly evolving era of anti-HCV drug development.Fil: Trinks, Julieta. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Caputo, Mariela. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Hulaniuk, María L.. Hospital Italiano. Instituto de Ciencias Básicas y Medicina Experimental; ArgentinaFil: Corach, Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Flichman, Diego Martin. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

On the square root of the inverse different

Let N/F be a finite, normal extension of number fields with Galois group G. Suppose that N/F is weakly ramified, and that the square root A(N/F) of the inverse different of N.F is defined. (This latter condition holds if, for example, G is of odd order.) B. Erez has conjectured that the class (A(N/F)) of A(N/F) in the locally free class group Cl(ZG) of ZG is equal to Chinburg's second Omega invariant attached to N/F. We show that this equality holds whenever A(N/F) is defined and N/F is tame. This extends a result of the second-named author and S. Vinatier