\u3ci\u3eAgonopterix Alstroemeriana\u3c/i\u3e (Oecophoridae) and Other Lepidopteran Associates of Poison Hemlock \u3ci\u3e(Conium Maculatum)\u3c/i\u3e in East Central Illinois

Poison hemlock (Conium maculatum) (Apiaceae), a noxious Eurasian weed extensively naturalized throughout North America, is characteristically attacked by few insects. Over the past two decades, an introduced oecophorid caterpillar, Agonopterix alstroemeriana, has been reported infesting poison hemlock, its sole host in its area of indigeneity, in parts of the northeastern and western United States. We report for the first time evidence of established midwestern populations of this species. We also report poison hemlock as a host plant for the polyphagous lepidopterans Eupithecia miserulata, Trichoplusia ni, and Spilosoma virginica

Psychological assessment of mothers and their daughters at the time of diagnosis of precocious puberty

BACKGROUND: Concerns about psychological distress are often used to justify treatment of girls with precocious puberty, but there is little evidence to support these concerns. The extent to which psychological problems are associated with central precocious puberty (CPP) compared with other forms of early puberty in girls has likewise not been established. METHODS: Girls presenting with untreated CPP, premature adrenarche (PA) or early normal puberty (ENP) were recruited from our pediatric endocrine clinic along with their mothers. Child psychological adjustment was assessed by child self-report and parent report. Parent self-reported personality, anxiety, and depression were also assessed. Differences between groups were explored using one-way ANOVA and Dunnett's T3 test. RESULTS: Sixty-two subjects (aged 7.5 ± 1.4 years, range 4.8-10.5) were enrolled, of whom 19 had CPP, 22 had PA, and 21 had ENP. Girls with ENP were significantly older (8.9 ± .9 years) than girls with CPP (6.9 ± 1.1 years, p < .001) and PA (6.6 ± 1.0 years, p < .001). Girls with PA had significantly higher BMI z-scores (1.7 ± .8) than girls with CPP (1.1 ± .6, p = .01) and ENP (1.2 ± .6, p = .04). More girls with PA and ENP were from racial minorities (47% and 50% respectively) than girls with CPP (32%). No group differences were found for any child measure of psychological adjustment. However, mothers of girls with PA scored significantly higher than mothers of girls with ENP on one measure of depression (p = .04) and stress (p = .01). CONCLUSIONS: While mothers of girls with PA report increased psychological distress on some measures, no differences in psychological adjustment were found at baseline amongst the girls themselves. Whether these results will change as puberty progresses in the PA and ENP groups or with treatment of CPP is unknown. Long-term prospective studies are needed in order to further investigate psychological correlates of early puberty in girls

Mixtures of four organochlorines enhance human breast cancer cell proliferation.

In view of the large differences between the concentrations of estrogenic chemicals needed to elicit effects in in vitro assays and their levels in human tissues, it is hard to explain possible health risks in terms of exposure to individual compounds. Human populations, however, are exposed to mixtures of estrogenic and estrogen-like agents and it is necessary to consider the impact of combined effects. We assessed the combined effects of 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2,2-trichloroethane (o,p'-DDT), 2,2-bis(p-chlorophenyl)-1,1-dichloroethylene (p,p'-DDE), beta-hexachlorocyclohexane (beta-HCH), and 1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane (p,p'-DDT) on the induction of cell proliferation in MCF-7 cells. All four compounds are persistent organochlorines that can be found in human tissues. We performed extensive concentration-response analyses with the single agents to predict the effects of two mixtures of all four compounds with different mixture ratios. We calculated the predictions by using the pharmacologically well-founded models of concentration addition and independent action and then tested them experimentally. o,p'-DDT, p,p'-DDE, beta-HCH, and p,p'-DDT acted together to produce proliferative effects in MCF-7 cells. The combined effect of the four agents could be predicted on the basis of data about single agent concentration-response relationships. Regression analysis demonstrated that there were combination effects even when each mixture component was present at levels at or below its individual no-observed-effect-concentration. We assessed combination effects in two ways: First, evaluations in relation to the proliferative responses induced by single mixture components revealed that the combination effects were stronger than the effects of the most potent constituent. Thus, according to this method of evaluation, the combined effects may be termed synergistic. Second, comparisons with the expected effects, as predicted by concentration addition and independent action, showed excellent agreement between prediction and observation. With this approach, the combined effect of all four compounds can be termed additive

Detecting depression in dyadic conversations with multimodal narratives and visualizations

Conversations contain a wide spectrum of multimodal information that gives us hints about the emotions and moods of the speaker. In this paper, we developed a system that supports humans to analyze conversations. Our main contribution is the identification of appropriate multimodal features and the integration of such features into verbatim conversation transcripts. We demonstrate the ability of our system to take in a wide range of multimodal information and automatically generated a prediction score for the depression state of the individual. Our experiments showed that this approach yielded better performance than the baseline model. Furthermore, the multimodal narrative approach makes it easy to integrate learnings from other disciplines, such as conversational analysis and psychology. Lastly, this interdisciplinary and automated approach is a step towards emulating how practitioners record the course of treatment as well as emulating how conversational analysts have been analyzing conversations by hand.Comment: 12 page

Early-Life Soy Exposure and Gender-Role Play Behavior in Children

Background: Soy-based infant formula contains high levels of isoflavones. These estrogen-like compounds have been shown to induce changes in sexually dimorphic behaviors in animals exposed in early development

Predicting selective drug targets in cancer through metabolic networks

The authors develop a genome-scale model of cancer metabolism and use it to predict genes that are essential for cancer cell growth. An array of target combinations are then identified that could potentially provide novel selective treatments for specific cancers