Measurement-induced macroscopic superposition states in cavity optomechanics

We present a novel proposal for generating quantum superpositions of macroscopically distinct states of a bulk mechanical oscillator, compatible with existing optomechanical devices operating in the readily achievable bad-cavity limit. The scheme is based on a pulsed cavity optomechanical quantum non-demolition (QND) interaction, driven by displaced non-Gaussian states, and measurement-induced feedback, avoiding the need for strong single-photon optomechanical coupling. Furthermore, we show that single-quadrature cooling of the mechanical oscillator is sufficient for efficient state preparation, and we outline a three-pulse protocol comprising a sequence of QND interactions for squeezing-enhanced cooling, state preparation, and tomography.Comment: 7 pages, 5 figure

Backflow in a Fermi Liquid

We calculate the backflow current around a fixed impurity in a Fermi liquid. The leading contribution at long distances is radial and proportional to 1/r^2. It is caused by the current induced density modulation first discussed by Landauer. The familiar 1/r^3 dipolar backflow obtained in linear response by Pines and Nozieres is only the next to leading term, whose strength is calculated here to all orders in the scattering. In the charged case the condition of perfect screening gives rise to a novel sum rule for the phase shifts. Similar to the behavior in a classical viscous liquid, the friction force is due only to the leading contribution in the backflow while the dipolar term does not contribute.Comment: 4 pages, 1 postscript figure, uses ReVTeX and epsfig macro, submitted to Physical Review Letter

Longitudinal Force on a Moving Potential

We show a formal result of the longitudinal force acting on a moving potential. The potential can be velocity-dependent, which appears in various interesting physical systems, such as electrons in the presence of a magnetic flux-line, or phonons scattering off a moving vortex. By using the phase-shift analysis, we are able to show the equivalence between the adiabatic perturbation theory and the kinetic theory for the longitudinal force in the dilute gas limit.Comment: RevTeX, 4 pages, revised tex

Backflow and dissipation during the quantum decay of a metastable Fermi liquid

The particle current in a metastable Fermi liquid against a first-order phase transition is calculated at zero temperature. During fluctuations of a droplet of the stable phase, in accordance with the conservation law, not only does an unperturbed current arise from the continuity at the boundary, but a backflow is induced by the density response. Quasiparticles carrying these currents are scattered by the boundary, yielding a dissipative backflow around the droplet. An energy of the hydrodynamic mass flow of the liquid and a friction force exerted on the droplet by the quasiparticles have been obtained in terms of a potential of their interaction with the droplet.Comment: 5 pages (REVTeX), to be published in Phys. Rev.

Floquet Formalism of Quantum Pumps

We review Floquet formalism of quantum electron pumps. In the Floquet formalism the quantum pump is regarded as a time dependent scattering system, which allows us to go beyond the adiabatic limit. It can be shown that the well-known adiabatic formula given by Brouwer can be derived from the adiabatic limit of Floquet formalism. We compare various physical properties of the quantum pump both in the adiabatic and in the non-adiabatic regime using the Floquet theory.Comment: Latex2e 16 pages, 6 figures. A review paper to appear in Int. J. Mod. Phys.

Microscopic theory of vortex dynamics in homogeneous superconductors

Vortex dynamics in fermionic superfluids is carefully considered from the microscopic point of view. Finite temperatures, as well as impurities, are explicitly incorporated. To enable readers understand the physical implications, macroscopic demonstrations based on thermodynamics and fluctuations- dissipation theorems are constructed. For the first time a clear summary and a critical review of previous results are given.Comment: Presentations are made more straightforward. A detailed presentation that why the vortex friction is finite when the geometric phase exists, as required by referees, though I think it is obviou

A glycosylated recombinant human granulocyte colony stimulating factor produced in a novel protein production system (AVI-014) in healthy subjects: a first-in human, single dose, controlled study

BACKGROUND: AVI-014 is an egg white-derived, recombinant, human granulocyte colony-stimulating factor (G-CSF). This healthy volunteer study is the first human investigation of AVI-014. METHODS: 24 male and female subjects received a single subcutaneous injection of AVI-014 at 4 or 8 mcg/kg. 16 control subjects received 4 or 8 mcg/kg of filgrastim (Neupogen, Amgen) in a partially blinded, parallel fashion. RESULTS: The Geometric Mean Ratio (GMR) (90% CI) of 4 mcg/kg AVI-014/filgrastim AUC(0-72 hr) was 1.00 (0.76, 1.31) and Cmax was 0.86 (0.66, 1.13). At the 8 mcg/kg dose, the AUC(0-72) GMR was 0.89 (0.69, 1.14) and Cmax was 0.76 (0.58, 0.98). A priori pharmacokinetic bioequivalence was defined as the 90% CI of the GMR bounded by 0.8-1.25. Both the white blood cell and absolute neutrophil count area under the % increase curve AUC(0-9 days) and Cmax (maximal % increase from baseline)GMR at 4 and 8 mcg/kg fell within the 0.5-2.0 a priori bound set for pharmacodynamic bioequivalence. The CD 34+ % increase curve AUC(0-9 days) and Cmax GMR for both doses was approximately 1, but 90% confidence intervals were large due to inherent variance, and this measure did not meet pharmacodynamic bioequivalence. AVI-014 demonstrated a side effect profile similar to that of filgrastim. CONCLUSION: AVI-014 has safety, pharmacokinetic, and pharmacodynamic properties comparable to filgrastim at an equal dose in healthy volunteers. These findings support further investigation in AVI-014