27 research outputs found
Standardizing the experimental conditions for using urine in NMR-based metabolomic studies with a particular focus on diagnostic studies: a review
Chaperoning the immunosuppressant mycophenolic acid through the gastrointestinal tract: A role for copper
Mycophenolic acid (MPA) is a frontline immunosuppressant that limits rejection of transplanted organs. Optimal use of this drug is hampered by gastrointestinal adverse events that are thought to be triggered during the absorption phase. These events have a negative impact on graft and patient survival. Previous work has suggested that similar gastrointestinal adverse events observed with non-steroidal antiinflammatory use can be limited by delivering the drug as a copper complex. We have recently shown that MPA is able to bind copper ions to form [Cu(MPA)2(H2O)2]. We report here that this complex is retained in a solvent that mimics the low pH, high salt environment of the upper gastrointestinal tract, suggesting that copper chelation may be a useful way to modulate and control MPA absorption. In an organic solvent, the complex can be modified using the physiologically relevant ligand imidazole to form [CuMPA(imid)3], however this complex is not retained in low pH conditions