2,243 research outputs found
Electrically tuneable exciton-polaritons through free electron doping in monolayer WS microcavities
We demonstrate control over light-matter coupling at room temperature
combining a field effect transistor (FET) with a tuneable optical microcavity.
Our microcavity FET comprises a monolayer tungsten disulfide WS
semiconductor which was transferred onto a hexagonal boron nitride flake that
acts as a dielectric spacer in the microcavity, and as an electric insulator in
the FET. In our tuneable system, strong coupling between excitons in the
monolayer WS and cavity photons can be tuned by controlling the cavity
length, which we achieved with excellent stability, allowing us to choose from
the second to the fifth order of the cavity modes. Once we achieve the strong
coupling regime, we then modify the oscillator strength of excitons in the
semiconductor material by modifying the free electron carrier density in the
conduction band of the WS. This enables strong Coulomb repulsion between
free electrons, which reduces the oscillator strength of excitons until the
Rabi splitting completely disappears. We controlled the charge carrier density
from 0 up to 3.2 10 cm, and over this range the Rabi
splitting varies from a maximum value that depends on the cavity mode chosen,
down to zero, so the system spans the strong to weak coupling regimes.Comment: Accepted for publicatio
A review of residual stress analysis using thermoelastic techniques
Thermoelastic Stress Analysis (TSA) is a full-field technique for experimental stress analysis
that is based on infra-red thermography. The technique has proved to be extremely effective for
studying elastic stress fields and is now well established. It is based on the measurement of the
temperature change that occurs as a result of a stress change. As residual stress is essentially a
mean stress it is accepted that the linear form of the TSA relationship cannot be used to
evaluate residual stresses. However, there are situations where this linear relationship is not
valid or departures in material properties due to manufacturing procedures have enabled
evaluations of residual stresses. The purpose of this paper is to review the current status of
using a TSA based approach for the evaluation of residual stresses and to provide some
examples of where promising results have been obtained
Fibroblasts derived from long-lived insulin receptor substrate 1 null mice are not resistant to multiple forms of stress
Reduced signalling through the insulin/insulin-like growth factor-1 signalling (IIS) pathway is a highly conserved lifespan determinant in model organisms. The precise mechanism underlying the effects of the IIS on lifespan and health is currently unclear, although cellular stress resistance may be important. We have previously demonstrated that mice globally lacking insulin receptor substrate 1 (Irs1−/−) are long-lived and enjoy a greater period of their life free from age-related pathology compared with wild-type (WT) controls. In this study, we show that primary dermal fibroblasts and primary myoblasts derived from Irs1−/− mice are no more resistant to a range of oxidant and nonoxidant chemical stressors than cells derived from WT mice
Piezomorphic materials
The development of stress-induced morphing materials which are described as piezomorphic materials is reported. The development of a piezomorphic material is achieved by introducing spatial dependency into the compliance matrix describing the elastic response of a material capable of undergoing large strain deformation. In other words, it is necessary to produce an elastically gradient material. This is achieved through modification of the microstructure of the compliant material to display gradient topology. Examples of polymeric (polyurethane) foam and microporous polymer (expanded polytetrafluoroethylene) piezomorphic materials are presented here. These materials open up new morphing applications where dramatic shape changes can be triggered by mechanical stress
Mammalian models of extended healthy lifespan
Over the last two centuries, there has been a significant increase in average lifespan expectancy in the developed world. One unambiguous clinical implication of getting older is the risk of experiencing age-related diseases including various cancers, dementia, type-2 diabetes, cataracts and osteoporosis. Historically, the ageing process and its consequences were thought to be intractable. However, over the last two decades or so, a wealth of empirical data has been generated which demonstrates that longevity in model organisms can be extended through the manipulation of individual genes. In particular, many pathological conditions associated with the ageing process in model organisms, and importantly conserved from nematodes to humans, are attenuated in long-lived genetic mutants. For example, several long-lived genetic mouse models show attenuation in age-related cognitive decline, adiposity, cancer and glucose intolerance. Therefore, these long-lived mice enjoy a longer period without suffering the various sequelae of ageing. The greatest challenge in the biology of ageing is to now identify the mechanisms underlying increased healthy lifespan in these model organisms. Given that the elderly are making up an increasingly greater proportion of society, this focused approach in model organisms should help identify tractable interventions that can ultimately be translated to humans
Ribosomal S6K1 in POMC and AgRP Neurons Regulates Glucose Homeostasis but Not Feeding Behavior in Mice.
SummaryHypothalamic ribosomal S6K1 has been suggested as a point of convergence for hormonal and nutrient signals in the regulation of feeding behavior, bodyweight, and glucose metabolism. However, the long-term effects of manipulating hypothalamic S6K1 signaling on energy homeostasis and the cellular mechanisms underlying these roles are unclear. We therefore inactivated S6K1 in pro-opiomelanocortin (POMC) and agouti-related protein (AgRP) neurons, key regulators of energy homeostasis, but in contrast to the current view, we found no evidence that S6K1 regulates food intake and bodyweight. In contrast, S6K1 signaling in POMC neurons regulated hepatic glucose production and peripheral lipid metabolism and modulated neuronal excitability. S6K1 signaling in AgRP neurons regulated skeletal muscle insulin sensitivity and was required for glucose sensing by these neurons. Our findings suggest that S6K1 signaling is not a general integrator of energy homeostasis in the mediobasal hypothalamus but has distinct roles in the regulation of glucose homeostasis by POMC and AgRP neurons
Reversible DNA micro-patterning using the fluorous effect
We describe a new method for the immobilisation of DNA into defined patterns with sub-micron resolution, using the fluorous effect. The method is fully reversible via a simple solvent wash, allowing the patterning, regeneration and re-patterning of surfaces with no degradation in binding efficiency following multiple removal/attachment cycles of different DNA sequences
Strategies to improve oral health behaviours and dental access for people experiencing homelessness: a qualitative study
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Polarization Selection Rules and Superconducting Gap Anisotropy in
We discuss polarization selection rules for angle-resolved photoemission
spectroscopy in Bi2212. Using these we show that the ``hump'' in the
superconducting gap observed in the quadrant in our earlier work is not on
the main band, but rather on an umklapp band arising from the
structural superlattice. The intrinsic gap is most likely quite small over a
range of about the diagonal directions.Comment: 3 pages, revtex, 3 uuencoded postscript figure
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