10 research outputs found
Ultrasonic Formation of Fe3O4βReduced Graphene OxideβSalicylic Acid Nanoparticles with Switchable Antioxidant Function
We demonstrate a single-step ultrasonic in situ complexation of salicylic acid during the growth of Fe3O4-reduced graphene oxide nanoparticles (βΌ10 nm) to improve the antioxidant and antiproliferative effects of pristine drug molecules. These nanoparticles have a precisely defined electronic molecular structure with salicylic acid ligands specifically complexed to Fe(III)/Fe(II) sites, four orders of magnitude larger electric surface potential, and enzymatic activity modulated by ascorbic acid molecules. The diminishing efficiency of hydroxyl radicals by Fe3O4-rGO-SA nanoparticles is tenfold higher than that by pristine salicylic acid in the electro-Fenton process. The H+ production of these nanoparticles can be switched by the interaction with ascorbic acid ligands and cause the redox deactivation of iron or enhanced antioxidation, where rGO plays an important role in enhanced charge transfer catalysis. Fe3O4-rGO-SA nanoparticles are nontoxic to erythrocytes, i.e., human peripheral blood mononuclear cells, but surpassingly inhibit the growth of three cancer cell lines, HeLa, HepG2, and HT29, with respect to pristine salicylic acid molecules
Properties of Nitrogen/Silicon Doped Vertically Oriented Graphene Produced by ICP CVD Roll-to-Roll Technology
Simultaneous mass production of high quality vertically oriented graphene nanostructures and doping them by using an inductively coupled plasma chemical vapor deposition (ICP CVD) is a technological problem because little is understood about their growth mechanism over enlarged surfaces. We introduce a new method that combines the ICP CVD with roll-to-roll technology to enable the in-situ preparation of vertically oriented graphene by using propane as a precursor gas and nitrogen or silicon as dopants. This new technology enables preparation of vertically oriented graphene with distinct morphology and composition on a moving copper foil substrate at a lower cost. The technological parameters such as deposition time (1β30 min), gas partial pressure, composition of the gas mixture (propane, argon, nitrogen or silane), heating treatment (1β60 min) and temperature (350β500 Β°C) were varied to reveal the nanostructure growth, the evolution of its morphology and heteroatomβs intercalation by nitrogen or silicon. Unique nanostructures were examined by FE-SEM microscopy, Raman spectroscopy and energy dispersive X-Ray scattering techniques. The undoped and nitrogen- or silicon-doped nanostructures can be prepared with the full area coverage of the copper substrate on industrially manufactured surface defects. Longer deposition time (30 min, 450 Β°C) causes carbon amorphization and an increased fraction of sp3-hybridized carbon, leading to enlargement of vertically oriented carbonaceous nanostructures and growth of pillars
Sonochemical Formation of Copper/Iron-modified Graphene Oxide Nanocomposites for Ketorolac Delivery
A feasible sonochemical approach is described for the preparation of copper/iron-modified graphene oxide nanocomposites by using ultrasound (20 kHz, 18 W/cm2) in aqueous solution containing copper and iron ion precursors. Unique copper-, copper/iron- and iron-modified graphene oxide nanocomposites have a submicron size that is smaller than pristine GO and a higher surface area enriched with Cu2O, CuO, Fe2O3 of multiform phases (Ξ±-, Ξ²-, Ξ΅- or Ξ³), FeO(OH) and sulfur- or carbon-containing compounds. These nanocomposites are sonochemically intercalated with the nonsteroidal anti-inflammatory drug ketorolac resulting in formation of nanoscale carriers. Ketorolac monotonically disintegrates from these nanoscale carriers in aqueous solution adjusted to pH from 1 to 8. The disintegration of ketorolac proceeds at a slower rate from the copper/iron-modified graphene oxide at increased pH, but at a faster rate from the iron-modified graphene oxide starting from acidic conditions
Ultrasonic Formation of Copper/Iron Graphene Oxide for Ketorolac Delivery
New accessible sonochemical methods were developed for the functionalization of synthesized graphene oxide (GO) with copper/iron compounds and drug intercalation into their structure in aqueous solution at ambient conditions by using ultrasound (20 kHz) treatment. The sonochemical formation mechanism of a new nanomaterial was revealed through the structural analysis of three types of nanocomposites: (i) copper@graphene oxide, (ii) copper/iron@-graphene oxide and (iii) iron@graphene oxide. Unique copper/iron-modied graphene oxide nanocomposites can be used as nanocarriers for the anti-inΒ°ammatory drug (ketorolac) delivery in aqueous solution due to the reduced submicron size and enlarged surface area. Disintegration of the ultrasonically intercalated ketorolac followed the exponential decay curve fit at higher pH values of the aqueous solution with a higher decay constant observed in copper/iron-modifed graphene oxide nanocomposites
ΠΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ ΡΠ»ΡΡΡΠ°Π·Π²ΡΠΊΠ° Π½Π° Π½Π΅ΡΡΠ΅ΡΠΎΠΈΠ΄Π½ΡΠ΅ ΠΏΡΠΎΡΠΈΠ²ΠΎΠ²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π° Π² ΠΊΠΎΠΌΠΏΠ»Π΅ΠΊΡΠ½ΡΡ ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΡΡ Π½Π°Π½ΠΎΠΊΠΎΠΌΠΏΠΎΠ·ΠΈΡΠΎΠ² Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΎΡΠΊΠΈΠ΄ΠΎΠ² ΠΌΠ΅Π΄ΠΈ, ΠΆΠ΅Π»Π΅Π·Π°, ΡΠΈΠ½ΠΊΠ° ΠΈ Π³ΡΠ°ΡΠ΅Π½Π°
This work aims at the formation of nanocomposites based on graphene and metal oxides (copper-iron, zinc and iron) through ultrasonic interaction (20 kHz) and investigation of their electromagnetic properties by scanning electron microscopy, Raman and absorption spectroscopy, and fluorescence methods. The output of this work implies the development of a single-step ultrasound method to form functional Cu/Fe-, ZnO-and Fe3O4-polyvinyl alcohol nanocomposites, and the ultrasonic conjugation of these nanocomposites with pristine drugs, such as ketorolac and acetylsalicylic acid. We established that formed Cu/Fe-graphene-ketorolac, ZnO-grapheneacetylsalicylic acid and Fe3O4-ketorolac obtain optical and superparamagnetic properties of nanoparticles with improved electromagnetic characteristics due to ultrasonic conjugation. Cu/Fe-graphene-ketorolac nanocomposites are revealed to have a spherical shape (< 100 nm) and acquire improved optoelectronic properties due to copper and iron atoms in the matrix of graphene. It is demonstrated that ZnO-graphene-acetylsalicylic acid nanocomposites obtain properties of fluorescence mainly for electromagnetic interaction with the ZnO phase formed on the surface of graphene. Ultrasonic conjugation of ketorolac with magnetite proved to increase the electron density of Fe3O4-ketorolac that obtains superparamagnetic properties, and its biocompatibility can be improved when coated with polyvinyl alcohol. In general, formed nanocomposites are of great interest in medical electronics and nanomedicine as functional materials with electromagnetic properties being controlled at the molecular and atomic levels. Such nanocomposites can also find application as components in electronic devices for diagnosis and treatment of serious inflammatory disorders. Industries will find the singlestep ultrasound method of special interest because it is eco-friendly and can be scaled up by a versatile spectrum of inorganic and organic materials and drugs.Π¦Π΅Π»ΡΡ ΡΠ°Π±ΠΎΡΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π½Π°Π½ΠΎΠΊΠΎΠΌΠΏΠΎΠ·ΠΈΡΠΎΠ² Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΎΠΊΡΠΈΠ΄ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π³ΡΠ°ΡΠ΅Π½Π° ΠΈ ΠΎΠΊΡΠΈΠ΄ΠΎΠ² ΠΌΠ΅ΡΠ°Π»Π»ΠΎΠ² (ΠΌΠ΅Π΄Ρ-ΠΆΠ΅Π»Π΅Π·ΠΎ, ΡΠΈΠ½ΠΊ ΠΈ ΠΆΠ΅Π»Π΅Π·ΠΎ) ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²ΠΎΠΌ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ Ρ ΡΠ»ΡΡΡΠ°Π·Π²ΡΠΊΠΎΠΌ (20 ΠΊΠΡ) ΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈΡ
ΡΠ»Π΅ΠΊΡΡΠΎΠΌΠ°Π³Π½ΠΈΡΠ½ΡΡ
ΡΠ²ΠΎΠΉΡΡΠ² Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΡΠΊΠ°Π½ΠΈΡΡΡΡΠ΅ΠΉ ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΠΎΠΉ ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΠΈ, ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΊΠΎΠΏΠΈΠΈ ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΡΠ°ΡΡΠ΅ΡΠ½ΠΈΡ ΡΠ²Π΅ΡΠ°, ΠΏΠΎΠ³Π»ΠΎΡΠ΅Π½ΠΈΡ ΡΠ»Π΅ΠΊΡΡΠΎΠΌΠ°Π³Π½ΠΈΡΠ½ΠΎΠ³ΠΎ ΠΈΠ·Π»ΡΡΠ΅Π½ΠΈΡ ΠΈ ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠΈΠΈ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠΌ ΡΠ°Π±ΠΎΡΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΠΎΠ΄Π½ΠΎΡΠ°Π³ΠΎΠ²ΠΎΠ³ΠΎ ΠΌΠ΅ΡΠΎΠ΄Π° ΡΠ»ΡΡΡΠ°Π·Π²ΡΠΊΠ° Π΄Π»Ρ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ
Π½Π°Π½ΠΎΠΊΠΎΠΌΠΏΠΎΠ·ΠΈΡΠΎΠ² Cu/Fe-, ZnO- ΠΈ Fe3O4-ΠΏΠΎΠ»ΠΈΠ²ΠΈΠ½ΠΈΠ»ΠΎΠ²ΡΠΉ ΡΠΏΠΈΡΡ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Π° ΡΠ»ΡΡΡΠ°Π·Π²ΡΠΊΠΎΠ²ΠΎΠ³ΠΎ ΠΊΠΎΠ½ΡΡΠ³ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈΡΡ
ΠΎΠ΄Π½ΡΡ
Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ, ΡΠ°ΠΊΠΈΡ
ΠΊΠ°ΠΊ ΠΊΠ΅ΡΠΎΡΠΎΠ»Π°ΠΊ ΠΈ Π°ΡΠ΅ΡΠΈΠ»ΡΠ°Π»ΠΈΡΠΈΠ»ΠΎΠ²Π°Ρ ΠΊΠΈΡΠ»ΠΎΡΠ°, Ρ Π΄Π°Π½Π½ΡΠΌΠΈ Π½Π°Π½ΠΎΠΊΠΎΠΌΠΏΠΎΠ·ΠΈΡΠ°ΠΌΠΈ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΠ΅ Π½Π°Π½ΠΎΠΊΠΎΠΌΠΏΠΎΠ·ΠΈΡΡ Cu/Fe-Π³ΡΠ°ΡΠ΅Π½-ΠΊΠ΅ΡΠΎΡΠΎΠ»Π°ΠΊ, ZnO-Π³ΡΠ°ΡΠ΅Π½-Π°ΡΠ΅ΡΠΈΠ»ΡΠ°Π»ΠΈΡΠΈΠ»ΠΎΠ²Π°Ρ ΠΊΠΈΡΠ»ΠΎΡΠ° ΠΈ Fe3O4-ΠΊΠ΅ΡΠΎΡΠΎΠ»Π°ΠΊ ΠΏΡΠΈΠΎΠ±ΡΠ΅ΡΠ°ΡΡ ΠΎΠΏΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈ ΡΡΠΏΠ΅ΡΠΏΠ°ΡΠ°ΠΌΠ°Π³Π½ΠΈΡΠ½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡ Ρ ΡΠ»ΡΡΡΠ΅Π½Π½ΡΠΌΠΈ ΡΠ»Π΅ΠΊΡΡΠΎΠΌΠ°Π³Π½ΠΈΡΠ½ΡΠΌΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ°ΠΌΠΈ Π±Π»Π°Π³ΠΎΠ΄Π°ΡΡ ΡΠ»ΡΡΡΠ°Π·Π²ΡΠΊΠΎΠ²ΠΎΠΉ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠΈΠΈ. ΠΡΡΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π½Π°Π½ΠΎΠΊΠΎΠΌΠΏΠΎΠ·ΠΈΡΡ Cu/Fe-Π³ΡΠ°ΡΠ΅Π½-ΠΊΠ΅ΡΠΎΡΠΎΠ»Π°ΠΊ ΠΈΠΌΠ΅ΡΡ ΡΡΠ΅ΡΠΈΡΠ΅ΡΠΊΡΡ ΡΠΎΡΠΌΡ ΠΈ ΡΠ°Π·ΠΌΠ΅Ρ, Π½Π΅ ΠΏΡΠ΅Π²ΡΡΠ°ΡΡΠΈΠΉ 100 Π½ΠΌ, Π½Π° ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠΈ ΠΏΠΎΡΠ»ΠΎΠΉΠ½ΠΎΠΉ ΡΡΡΡΠΊΡΡΡΡ ΠΎΠΊΡΠΈΠ΄ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π³ΡΠ°ΡΠ΅Π½Π°. Π‘ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ Π½Π°Π½ΠΎΠΊΠΎΠΌΠΏΠΎΠ·ΠΈΡΡ Cu/Fe-Π³ΡΠ°ΡΠ΅Π½-ΠΊΠ΅ΡΠΎΡΠΎΠ»Π°ΠΊ ΠΏΡΠΈΠΎΠ±ΡΠ΅ΡΠ°ΡΡ ΡΠ»ΡΡΡΠ΅Π½Π½ΡΠ΅ ΠΎΠΏΡΠΎΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° Π±Π»Π°Π³ΠΎΠ΄Π°ΡΡ Π½Π°Π»ΠΈΡΠΈΡ Π°ΡΠΎΠΌΠΎΠ² ΠΌΠ΅Π΄ΠΈ ΠΈ ΠΆΠ΅Π»Π΅Π·Π° Π² ΠΌΠ°ΡΡΠΈΡΠ΅ Π³ΡΠ°ΡΠ΅Π½Π°. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π½Π°Π½ΠΎΠΊΠΎΠΌΠΏΠΎΠ·ΠΈΡΡ ZnO-Π³ΡΠ°ΡΠ΅Π½-Π°ΡΠ΅ΡΠΈΠ»ΡΠ°Π»ΠΈΡΠΈΠ»ΠΎΠ²Π°Ρ ΠΊΠΈΡΠ»ΠΎΡΠ° ΠΏΡΠΈΠΎΠ±ΡΠ΅ΡΠ°ΡΡ ΡΠ»ΡΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠΈΠΈ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ Π·Π° ΡΡΠ΅Ρ ΡΠ»Π΅ΠΊΡΡΠΎΠΌΠ°Π³Π½ΠΈΡΠ½ΠΎΠ³ΠΎ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ Ρ ΡΠ°Π·ΠΎΠΉ ΠΎΠΊΡΠΈΠ΄Π° ΡΠΈΠ½ΠΊΠ°, ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π½Π° ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠΈ Π³ΡΠ°ΡΠ΅Π½Π°. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΊΠΎΠ½ΡΡΠ³ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠ΅ΡΠΎΡΠΎΠ»Π°ΠΊΠ° Ρ ΠΌΠ°Π³Π½Π΅ΡΠΈΡΠΎΠΌ ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°Π΅Ρ ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΡΡ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΡ Π½Π°Π½ΠΎΠΊΠΎΠΌΠΏΠΎΠ·ΠΈΡΠ° Fe3O4-ΠΊΠ΅ΡΠΎΡΠΎΠ»Π°ΠΊ, ΠΊΠΎΡΠΎΡΡΠΉ ΠΏΡΠΈΠΎΠ±ΡΠ΅ΡΠ°Π΅Ρ ΡΡΠΏΠ΅ΡΠΏΠ°ΡΠ°ΠΌΠ°Π³Π½ΠΈΡΠ½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π°, Π° Π΅Π³ΠΎ ΠΏΠΎΠΊΡΡΡΠΈΠ΅ ΠΏΠΎΠ»ΠΈΠ²ΠΈΠ½ΠΈΠ»ΠΎΠ²ΡΠΌ ΡΠΏΠΈΡΡΠΎΠΌ ΠΌΠΎΠΆΠ΅Ρ ΡΠ»ΡΡΡΠΈΡΡ Π±ΠΈΠΎΡΠΎΠ²ΠΌΠ΅ΡΡΠΈΠΌΠΎΡΡΡ. Π ΡΠ΅Π»ΠΎΠΌ ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ Π½Π°Π½ΠΎΠΊΠΎΠΌΠΏΠΎΠ·ΠΈΡΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΡΡ Π±ΠΎΠ»ΡΡΠΎΠΉ ΠΈΠ½ΡΠ΅ΡΠ΅Ρ Π² ΠΎΠ±Π»Π°ΡΡΠΈ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠΉ ΡΠ»Π΅ΠΊΡΡΠΎΠ½ΠΈΠΊΠΈ ΠΈ Π½Π°Π½ΠΎΠΌΠ΅Π΄ΠΈΡΠΈΠ½Ρ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ
ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠ² Ρ ΡΠ»ΡΡΡΠ΅Π½Π½ΡΠΌΠΈ ΡΠ»Π΅ΠΊΡΡΠΎΠΌΠ°Π³Π½ΠΈΡΠ½ΡΠΌΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π°ΠΌΠΈ, ΠΊΠΎΠ½ΡΡΠΎΠ»ΠΈΡΡΠ΅ΠΌΡΠΌΠΈ Π½Π° ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠΌ ΠΈ Π°ΡΠΎΠΌΠ½ΠΎΠΌ ΡΡΠΎΠ²Π½Π΅. ΠΠ°Π½Π½ΡΠ΅ Π½Π°Π½ΠΎΠΊΠΎΠΌΠΏΠΎΠ·ΠΈΡΡ ΠΌΠΎΠ³ΡΡ Π½Π°ΠΉΡΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΊΠ°ΠΊ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠ², ΡΠ°ΠΊ ΠΈ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² Π² ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΡΡ
ΡΡΡΡΠΎΠΉΡΡΠ²Π°Ρ
Π΄Π»Ρ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ Π²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ. ΠΠ»Ρ ΠΏΡΠΎΠΌΡΡΠ»Π΅Π½Π½ΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΠΈ ΠΎΡΠΎΠ±ΡΠΉ ΠΈΠ½ΡΠ΅ΡΠ΅Ρ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅Ρ ΠΎΠ΄Π½ΠΎΡΠ°Π³ΠΎΠ²ΡΠΉ ΡΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ ΡΠΈΡΡΡΠΉ ΠΌΠ΅ΡΠΎΠ΄ ΡΠ»ΡΡΡΠ°Π·Π²ΡΠΊΠ°, ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΊΠΎΡΠΎΡΠΎΠ³ΠΎ ΠΌΠΎΠΆΠ½ΠΎ ΡΠ°ΡΡΠΈΡΠΈΡΡ ΡΠ°Π·Π½ΠΎΠΎΠ±ΡΠ°Π·Π½ΡΠΌ ΡΠΏΠ΅ΠΊΡΡΠΎΠΌ Π½Π΅ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠ² ΠΈ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
Π²Π΅ΡΠ΅ΡΡΠ²
Sonochemically Assembled Photoluminescent Copper Modified Graphene Oxide Microspheres
New accessible sonochemical assembly method is developed for the preparation of photoluminescent oil-filled silica@CuS/Cu2O/CuO-GO microspheres with green, yellow and red colors of emitted light. This method is based on the ultrasonic emulsification of a biphasic mixture consisting of CuS/Cu2O/CuO-graphene oxide (GO) nanocomposites with polyvinyl alcohol (PVA) (aqueous phase) and tetraethyl orthosilicate with sunflower oil (organic phase). CuS/Cu2O/CuO-GO nanocomposites are composed of sonochemically formed three phases of copper: covellite CuS (p-type semiconductor), cuprite Cu2O (Bloch p-type semiconductor) and CuO (charge transfer insulator). The photoluminescence property of microspheres results from the H-bridging between PVA and CuS/Cu2O/CuO-GO nanostructures, light absorption ability of Cu2O and charge transfer insulation by CuO. Substitution of PVA by S-containing methylene blue quenches fluorescence by enhanced dye adsorption on CuS/Cu2O/CuO-GO because of CuS and induced charge transfer. Non-S-containing malachite green is in non-ionized form and tends to be in the oil phase, prohibiting the charge transfer on CuS/Cu2O/CuO-GO
Effect of ultrasound on nonsteroidal anti-inflammatory drugs complexed with copper, iron, zinc and graphene oxides
This work aims at the formation of nanocomposites based on graphene and metal oxides (copper-iron, zinc and iron) through ultrasonic interaction (20 kHz) and investigation of their electromagnetic properties by scanning electron microscopy, Raman and absorption spectroscopy, and fluorescence methods. The output of this work implies the development of a single-step ultrasound method to form functional Cu/Fe-, ZnO-and Fe3O4-polyvinyl alcohol nanocomposites, and the ultrasonic conjugation of these nanocomposites with pristine drugs, such as ketorolac and acetylsalicylic acid. We established that formed Cu/Fe-graphene-ketorolac, ZnO-grapheneacetylsalicylic acid and Fe3O4-ketorolac obtain optical and superparamagnetic properties of nanoparticles with improved electromagnetic characteristics due to ultrasonic conjugation. Cu/Fe-graphene-ketorolac nanocomposites are revealed to have a spherical shape (< 100 nm) and acquire improved optoelectronic properties due to copper and iron atoms in the matrix of graphene. It is demonstrated that ZnO-graphene-acetylsalicylic acid nanocomposites obtain properties of fluorescence mainly for electromagnetic interaction with the ZnO phase formed on the surface of graphene. Ultrasonic conjugation of ketorolac with magnetite proved to increase the electron density of Fe3O4-ketorolac that obtains superparamagnetic properties, and its biocompatibility can be improved when coated with polyvinyl alcohol. In general, formed nanocomposites are of great interest in medical electronics and nanomedicine as functional materials with electromagnetic properties being controlled at the molecular and atomic levels. Such nanocomposites can also find application as components in electronic devices for diagnosis and treatment of serious inflammatory disorders. Industries will find the singlestep ultrasound method of special interest because it is eco-friendly and can be scaled up by a versatile spectrum of inorganic and organic materials and drugs
Properties of copper/iron-modified graphene oxide nanocomposites for applications in nanomedicine
Feasible ultrasonic method (20 kHz) was developed for the preparation of new CuS/Cu2O/CuO and copper/iron-modified graphene
oxide nanocomposites with advanced charge carrier properties. Methylene blue dye was used as a probe of the charge transfer
property on the surface of CuS/Cu2O/CuO-graphene oxide in the silica network. It was revealed that the fluorescence from the dye
was quenched as aresult of the interacton induced by the charge transfer on the CuS/Cu2O/CuO-GO surface. In addition, unique
copper- and copper/iron composition of the graphene oxide nanocomposite can be used as a molecular carrier for the antiinflammatory drug ketorolac due to the ultrasonically formed particular binding or complexation mechanisms
Effect of ultrasound on nonsteroidal anti-inflammatory drugs complexed with copper, iron, zinc and graphene oxides
Π¦Π΅Π»ΡΡ ΡΠ°Π±ΠΎΡΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ Π½Π°Π½ΠΎΠΊΠΎΠΌΠΏΠΎΠ·ΠΈΡΠΎΠ² Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΎΠΊΡΠΈΠ΄ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π³ΡΠ°ΡΠ΅Π½Π° ΠΈ ΠΎΠΊΡΠΈΠ΄ΠΎΠ² ΠΌΠ΅ΡΠ°Π»Π»ΠΎΠ² (ΠΌΠ΅Π΄Ρ-ΠΆΠ΅Π»Π΅Π·ΠΎ, ΡΠΈΠ½ΠΊ ΠΈ ΠΆΠ΅Π»Π΅Π·ΠΎ) ΠΏΠΎΡΡΠ΅Π΄ΡΡΠ²ΠΎΠΌ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ Ρ ΡΠ»ΡΡΡΠ°Π·Π²ΡΠΊΠΎΠΌ (20 ΠΊΠΡ) ΠΈ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ ΠΈΡ
ΡΠ»Π΅ΠΊΡΡΠΎΠΌΠ°Π³Π½ΠΈΡΠ½ΡΡ
ΡΠ²ΠΎΠΉΡΡΠ² Ρ ΠΏΠΎΠΌΠΎΡΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΡΠΊΠ°Π½ΠΈΡΡΡΡΠ΅ΠΉ ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΠΎΠΉ ΠΌΠΈΠΊΡΠΎΡΠΊΠΎΠΏΠΈΠΈ, ΡΠΏΠ΅ΠΊΡΡΠΎΡΠΊΠΎΠΏΠΈΠΈ ΠΊΠΎΠΌΠ±ΠΈΠ½Π°ΡΠΈΠΎΠ½Π½ΠΎΠ³ΠΎ ΡΠ°ΡΡΠ΅ΡΠ½ΠΈΡ ΡΠ²Π΅ΡΠ°, ΠΏΠΎΠ³Π»ΠΎΡΠ΅Π½ΠΈΡ ΡΠ»Π΅ΠΊΡΡΠΎΠΌΠ°Π³Π½ΠΈΡΠ½ΠΎΠ³ΠΎ ΠΈΠ·Π»ΡΡΠ΅Π½ΠΈΡ ΠΈ ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠΈΠΈ. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΠΎΠΌ ΡΠ°Π±ΠΎΡΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΠΎΠ΄Π½ΠΎΡΠ°Π³ΠΎΠ²ΠΎΠ³ΠΎ ΠΌΠ΅ΡΠΎΠ΄Π° ΡΠ»ΡΡΡΠ°Π·Π²ΡΠΊΠ° Π΄Π»Ρ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ
Π½Π°Π½ΠΎΠΊΠΎΠΌΠΏΠΎΠ·ΠΈΡΠΎΠ² Cu/Fe-, ZnO- ΠΈ Fe3O4-ΠΏΠΎΠ»ΠΈΠ²ΠΈΠ½ΠΈΠ»ΠΎΠ²ΡΠΉ ΡΠΏΠΈΡΡ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Π° ΡΠ»ΡΡΡΠ°Π·Π²ΡΠΊΠΎΠ²ΠΎΠ³ΠΎ ΠΊΠΎΠ½ΡΡΠ³ΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΠΈΡΡ
ΠΎΠ΄Π½ΡΡ
Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
ΡΠΎΠ΅Π΄ΠΈΠ½Π΅Π½ΠΈΠΉ, ΡΠ°ΠΊΠΈΡ
ΠΊΠ°ΠΊ ΠΊΠ΅ΡΠΎΡΠΎΠ»Π°ΠΊ ΠΈ Π°ΡΠ΅ΡΠΈΠ»ΡΠ°Π»ΠΈΡΠΈΠ»ΠΎΠ²Π°Ρ ΠΊΠΈΡΠ»ΠΎΡΠ°, Ρ Π΄Π°Π½Π½ΡΠΌΠΈ Π½Π°Π½ΠΎΠΊΠΎΠΌΠΏΠΎΠ·ΠΈΡΠ°ΠΌΠΈ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΠ΅ Π½Π°Π½ΠΎΠΊΠΎΠΌΠΏΠΎΠ·ΠΈΡΡ Cu/Fe-Π³ΡΠ°ΡΠ΅Π½-ΠΊΠ΅ΡΠΎΡΠΎΠ»Π°ΠΊ, ZnO-Π³ΡΠ°ΡΠ΅Π½-Π°ΡΠ΅ΡΠΈΠ»ΡΠ°Π»ΠΈΡΠΈΠ»ΠΎΠ²Π°Ρ ΠΊΠΈΡΠ»ΠΎΡΠ° ΠΈ Fe3O4-ΠΊΠ΅ΡΠΎΡΠΎΠ»Π°ΠΊ ΠΏΡΠΈΠΎΠ±ΡΠ΅ΡΠ°ΡΡ ΠΎΠΏΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΈ ΡΡΠΏΠ΅ΡΠΏΠ°ΡΠ°ΠΌΠ°Π³Π½ΠΈΡΠ½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° Π½Π°Π½ΠΎΡΠ°ΡΡΠΈΡ Ρ ΡΠ»ΡΡΡΠ΅Π½Π½ΡΠΌΠΈ ΡΠ»Π΅ΠΊΡΡΠΎΠΌΠ°Π³Π½ΠΈΡΠ½ΡΠΌΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ°ΠΌΠΈ Π±Π»Π°Π³ΠΎΠ΄Π°ΡΡ ΡΠ»ΡΡΡΠ°Π·Π²ΡΠΊΠΎΠ²ΠΎΠΉ ΠΊΠΎΠ½ΡΡΠ³Π°ΡΠΈΠΈ. ΠΡΡΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π½Π°Π½ΠΎΠΊΠΎΠΌΠΏΠΎΠ·ΠΈΡΡ Cu/Fe-Π³ΡΠ°ΡΠ΅Π½-ΠΊΠ΅ΡΠΎΡΠΎΠ»Π°ΠΊ ΠΈΠΌΠ΅ΡΡ ΡΡΠ΅ΡΠΈΡΠ΅ΡΠΊΡΡ ΡΠΎΡΠΌΡ ΠΈ ΡΠ°Π·ΠΌΠ΅Ρ, Π½Π΅ ΠΏΡΠ΅Π²ΡΡΠ°ΡΡΠΈΠΉ 100 Π½ΠΌ, Π½Π° ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠΈ ΠΏΠΎΡΠ»ΠΎΠΉΠ½ΠΎΠΉ ΡΡΡΡΠΊΡΡΡΡ ΠΎΠΊΡΠΈΠ΄ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π³ΡΠ°ΡΠ΅Π½Π°. Π‘ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ Π½Π°Π½ΠΎΠΊΠΎΠΌΠΏΠΎΠ·ΠΈΡΡ Cu/Fe-Π³ΡΠ°ΡΠ΅Π½-ΠΊΠ΅ΡΠΎΡΠΎΠ»Π°ΠΊ ΠΏΡΠΈΠΎΠ±ΡΠ΅ΡΠ°ΡΡ ΡΠ»ΡΡΡΠ΅Π½Π½ΡΠ΅ ΠΎΠΏΡΠΎΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° Π±Π»Π°Π³ΠΎΠ΄Π°ΡΡ Π½Π°Π»ΠΈΡΠΈΡ Π°ΡΠΎΠΌΠΎΠ² ΠΌΠ΅Π΄ΠΈ ΠΈ ΠΆΠ΅Π»Π΅Π·Π° Π² ΠΌΠ°ΡΡΠΈΡΠ΅ Π³ΡΠ°ΡΠ΅Π½Π°. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ Π½Π°Π½ΠΎΠΊΠΎΠΌΠΏΠΎΠ·ΠΈΡΡ ZnO-Π³ΡΠ°ΡΠ΅Π½-Π°ΡΠ΅ΡΠΈΠ»ΡΠ°Π»ΠΈΡΠΈΠ»ΠΎΠ²Π°Ρ ΠΊΠΈΡΠ»ΠΎΡΠ° ΠΏΡΠΈΠΎΠ±ΡΠ΅ΡΠ°ΡΡ ΡΠ»ΡΡΡΠ΅Π½Π½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π° ΡΠ»ΡΠΎΡΠ΅ΡΡΠ΅Π½ΡΠΈΠΈ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ Π·Π° ΡΡΠ΅Ρ ΡΠ»Π΅ΠΊΡΡΠΎΠΌΠ°Π³Π½ΠΈΡΠ½ΠΎΠ³ΠΎ Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡ Ρ ΡΠ°Π·ΠΎΠΉ ΠΎΠΊΡΠΈΠ΄Π° ΡΠΈΠ½ΠΊΠ°, ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π½Π° ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠΈ Π³ΡΠ°ΡΠ΅Π½Π°. ΠΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΠΊΠΎΠ½ΡΡΠ³ΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΊΠ΅ΡΠΎΡΠΎΠ»Π°ΠΊΠ° Ρ ΠΌΠ°Π³Π½Π΅ΡΠΈΡΠΎΠΌ ΡΠ²Π΅Π»ΠΈΡΠΈΠ²Π°Π΅Ρ ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΡΡ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΡ Π½Π°Π½ΠΎΠΊΠΎΠΌΠΏΠΎΠ·ΠΈΡΠ° Fe3O4-ΠΊΠ΅ΡΠΎΡΠΎΠ»Π°ΠΊ, ΠΊΠΎΡΠΎΡΡΠΉ ΠΏΡΠΈΠΎΠ±ΡΠ΅ΡΠ°Π΅Ρ ΡΡΠΏΠ΅ΡΠΏΠ°ΡΠ°ΠΌΠ°Π³Π½ΠΈΡΠ½ΡΠ΅ ΡΠ²ΠΎΠΉΡΡΠ²Π°, Π° Π΅Π³ΠΎ ΠΏΠΎΠΊΡΡΡΠΈΠ΅ ΠΏΠΎΠ»ΠΈΠ²ΠΈΠ½ΠΈΠ»ΠΎΠ²ΡΠΌ ΡΠΏΠΈΡΡΠΎΠΌ ΠΌΠΎΠΆΠ΅Ρ ΡΠ»ΡΡΡΠΈΡΡ Π±ΠΈΠΎΡΠΎΠ²ΠΌΠ΅ΡΡΠΈΠΌΠΎΡΡΡ. Π ΡΠ΅Π»ΠΎΠΌ ΡΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½Π½ΡΠ΅ Π½Π°Π½ΠΎΠΊΠΎΠΌΠΏΠΎΠ·ΠΈΡΡ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΡΡ Π±ΠΎΠ»ΡΡΠΎΠΉ ΠΈΠ½ΡΠ΅ΡΠ΅Ρ Π² ΠΎΠ±Π»Π°ΡΡΠΈ ΠΌΠ΅Π΄ΠΈΡΠΈΠ½ΡΠΊΠΎΠΉ ΡΠ»Π΅ΠΊΡΡΠΎΠ½ΠΈΠΊΠΈ ΠΈ Π½Π°Π½ΠΎΠΌΠ΅Π΄ΠΈΡΠΈΠ½Ρ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ
ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠ² Ρ ΡΠ»ΡΡΡΠ΅Π½Π½ΡΠΌΠΈ ΡΠ»Π΅ΠΊΡΡΠΎΠΌΠ°Π³Π½ΠΈΡΠ½ΡΠΌΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π°ΠΌΠΈ, ΠΊΠΎΠ½ΡΡΠΎΠ»ΠΈΡΡΠ΅ΠΌΡΠΌΠΈ Π½Π° ΠΌΠΎΠ»Π΅ΠΊΡΠ»ΡΡΠ½ΠΎΠΌ ΠΈ Π°ΡΠΎΠΌΠ½ΠΎΠΌ ΡΡΠΎΠ²Π½Π΅. ΠΠ°Π½Π½ΡΠ΅ Π½Π°Π½ΠΎΠΊΠΎΠΌΠΏΠΎΠ·ΠΈΡΡ ΠΌΠΎΠ³ΡΡ Π½Π°ΠΉΡΠΈ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΊΠ°ΠΊ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠ², ΡΠ°ΠΊ ΠΈ ΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠΎΠ² Π² ΡΠ»Π΅ΠΊΡΡΠΎΠ½Π½ΡΡ
ΡΡΡΡΠΎΠΉΡΡΠ²Π°Ρ
Π΄Π»Ρ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΈ Π»Π΅ΡΠ΅Π½ΠΈΡ Π²ΠΎΡΠΏΠ°Π»ΠΈΡΠ΅Π»ΡΠ½ΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ. ΠΠ»Ρ ΠΏΡΠΎΠΌΡΡΠ»Π΅Π½Π½ΠΎΠΉ ΠΎΠ±Π»Π°ΡΡΠΈ ΠΎΡΠΎΠ±ΡΠΉ ΠΈΠ½ΡΠ΅ΡΠ΅Ρ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΠ΅Ρ ΠΎΠ΄Π½ΠΎΡΠ°Π³ΠΎΠ²ΡΠΉ ΡΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ ΡΠΈΡΡΡΠΉ ΠΌΠ΅ΡΠΎΠ΄ ΡΠ»ΡΡΡΠ°Π·Π²ΡΠΊΠ°, ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΊΠΎΡΠΎΡΠΎΠ³ΠΎ ΠΌΠΎΠΆΠ½ΠΎ ΡΠ°ΡΡΠΈΡΠΈΡΡ ΡΠ°Π·Π½ΠΎΠΎΠ±ΡΠ°Π·Π½ΡΠΌ ΡΠΏΠ΅ΠΊΡΡΠΎΠΌ Π½Π΅ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ ΠΎΡΠ³Π°Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠ² ΠΈ Π»Π΅ΠΊΠ°ΡΡΡΠ²Π΅Π½Π½ΡΡ
Π²Π΅ΡΠ΅ΡΡΠ². This work aims at the formation of nanocomposites based on graphene and metal oxides (copper-iron, zinc and iron) through ultrasonic interaction (20 kHz) and investigation of their electromagnetic properties by scanning electron microscopy, Raman and absorption spectroscopy, and fluorescence methods. The output of this work implies the development of a single-step ultrasound method to form functional Cu/Fe-, ZnO-and Fe3O4-polyvinyl alcohol nanocomposites, and the ultrasonic conjugation of these nanocomposites with pristine drugs, such as ketorolac and acetylsalicylic acid. We established that formed Cu/Fe-graphene-ketorolac, ZnO-grapheneacetylsalicylic acid and Fe3O4-ketorolac obtain optical and superparamagnetic properties of nanoparticles with improved electromagnetic characteristics due to ultrasonic conjugation. Cu/Fe-graphene-ketorolac nanocomposites are revealed to have a spherical shape (< 100 nm) and acquire improved optoelectronic properties due to copper and iron atoms in the matrix of graphene. It is demonstrated that ZnO-graphene-acetylsalicylic acid nanocomposites obtain properties of fluorescence mainly for electromagnetic interaction with the ZnO phase formed on the surface of graphene. Ultrasonic conjugation of ketorolac with magnetite proved to increase the electron density of Fe3O4-ketorolac that obtains superparamagnetic properties, and its biocompatibility can be improved when coated with polyvinyl alcohol. In general, formed nanocomposites are of great interest in medical electronics and nanomedicine as functional materials with electromagnetic properties being controlled at the molecular and atomic levels. Such nanocomposites can also find application as components in electronic devices for diagnosis and treatment of serious inflammatory disorders. Industries will find the singlestep ultrasound method of special interest because it is eco-friendly and can be scaled up by a versatile spectrum of inorganic and organic materials and drugs