Genetic Polymorphisms and Antifolate Drug Treatment Can Alter Folate/Homocysteine Metabolism and Inflammatory Protein Profile

The folate metabolic pathway is important in several biological processes, including purine and pyrimidine synthesis and the methylation of DNA and proteins. There are several pathologies that are associated with dysregulation of the folate/homocysteine (Hcy) metabolic pathway, including rheumatoid arthritis (RA), cardiovascular disease (CVD), and several cancers. Many of the pathologies associated with altered folate/Hcy metabolism have underlying inflammatory etiology. The distribution of folate derivatives can be influenced by nutrient deficiency or insufficiency and by genetic polymorphisms in important enzymes in the pathway. Additionally, antifolate drugs, such as methotrexate (MTX) and pemetrexed (PMX), modify folate/Hcy metabolism. The relationships between folate phenotype, genetic polymorphisms of folate pathway enzymes, and inflammatory proteins were examined in both population-based and cell culture studies. A study set of young adults was used to study these relationships in a healthy population. In females, MCP-1 concentrations were positively correlated with Hcy and negatively correlated with both serum and red blood cell folate; female MTHFR 677T carriers had particularly elevated MCP-1 concentrations. In an observational follow-up study of patients prescribed MTX, total folate concentration decreased and MCP-1 concentration increased between their initial (i.e. before starting MTX) and on-drug treatment visits. MTHFR 677C\u3eT genotype was associated with changes in several of the clinical and biochemical variables examined. Additionally, changes in MCP-1 and IL-8 concentrations were positively correlated with one another. Treatment of EA.hy 926 endothelial cells with PMX caused a decrease in individual folate analytes in both cells adapted to growth in low folate conditions and folate-replete cells. Several genes were significantly up or down-regulated in PMX-treated Lo cells. Additionally, IL-8 and C3 protein concentrations were increased following PMX treatment in cells grown under low folate conditions. PMX drug treatment was shown in this study to have effects that lead to an increase in pro-inflammatory mediators in these folate-deplete cells. In a study of lung cancer patients and matched controls, the lung cancer cases had higher total red blood cell (RBC) folate and RBC 5-MTHF concentrations. Additionally, there were 38 MTHFR 677TT homozygotes in the cases, but only 24 controls had this genotype

Body Image and Beauty Routines Among College Women: Genital Grooming and Sexual Attitudes

The selection of body altering products available to twenty-first century women is easily accessible and widely utilized. These products, though, are vastly different from those once available to their female predecessors. Although women’s bodies have been sites for societal pressure and control for centuries before the twenty-first, American girls in this century experience body image norms and pressures in qualitatively different ways than girls who came before them. Of particular interest to this study is the differing bodily experience of early twentieth century women to that of twenty-first century women. The trading in of corsets and floor-length dresses for razors and bikinis is a key change in terms of this research. By using a historical context as well as sociological theory and methods, this research aims to understand women’s current body trends, especially those pertaining to genital alteration as they relate to societal pressures and genital self-esteem levels. As such, this project seeks specifically to examine women’s beauty routines and practices, especially relating to genital alteration, societal pressures, and genital self-esteem. As such, this project seeks to understand the bodily experiences of women and the bodily choices they make and why. Emergent themes this thesis explores include: beauty routines: mom and the media; puberty stories; intimate partner expectations; female genital self-image; and the ideal vagina

Radial transmission line analysis of multi-layer structures

The analysis of multi-layer beam tubes is a standard problem and involves axially propagating waves. This treatment is ill suited to a short multi-layer structure such as the present example of a ferrite covered ceramic break in the beam tube at the ERL photo-cathode electron gun. This paper demonstrates that such structure can better be treated by radial wave propagation. The theoretical method is presented and numerical results are compared with measured network analyser data and Microwave Studio generated simulations. The results confirm the concept of radial transmission lines as a valid analytical method. An Energy Recovery Linac (ERL) is being constructed at this laboratory for the purpose of research towards an envisioned Electron Ion Collider. One of the pertinent topics is damping of Higher Order Modes (HOM). In this ERL, the damping is provided by ferrite absorbers in the beam tube. A modified version thereof, a ceramic break surrounded by ferrite, is planed for the superconducting electron gun. The damper here is located at room temperature just outside of the gun. If used in a cavity chain, the ceramic break is in the vacuum tube at helium temperature whereas the ferrite is moved into the cryostat insulating vacuum allowing higher temperatures. The general properties of the ferrite HOM dampers have been published but are more detailed in this paper

Measurement of groove features and dimensions of the vertical test cathode and the choke joint of the superconducting electron gun cavity of the Energy Recovery LINAC

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Curve fitting with the Bubble Board

The bubble board is a device to create simultaneously 56 identical soap bubbles. Students study the relation between time and the number of remaining bubbles for different concentrations of glycerin and use linear, exponential, and logistic decay models to fit the data

Expanding our reach: Implementing instructor development programming

Academic libraries strive to support the teaching and learning goals of their institutions, frequently resulting in "one-shot" sessions for students, in which librarians share their expertise related to information literacy and/or library resources. Another method by which libraries can support teaching practices at our institutions is by facilitating instructor development programming. In this article, we discuss the creation of two significant instructor development offerings to support course instructors in teaching information literacy. Participants indicated satisfaction with the workshops and that they are likely to recommend them to their colleagues. By providing this programming, we are able to reach new audiences and highlight the library's role as an engaged partner in teaching and learning.Publisher does not allow open access until after publicatio

Discovery Panel I & II

90 minute session is to provide a comprehensive view on discovery by bringing together experts in Primo and Summon to discuss, compare and contrast several aspects of discovery services. Beyond a product perspective the panel also represents the interests of North American and International customers. Topics for Part One: Infrastructure, Configuration & Customization Topics for Part Two: Collections, Usability, Analytics & Suppor

Enabling Inclusive and Equitable Teaching Practices through Instructor Development

In The Ohio State University Libraries, we support inclusive and equitable teaching practices through instructor development. The Libraries' Teaching and Learning department offers two formal university-wide, cross-campus instructor development programs, Meaningful Inquiry and Teaching Information Literacy. In this chapter, we outline our programs, highlight the equity-focused pedagogical strategies that we incorporate, and provide activities and templates readers can use to support equity and inclusion in their own work with instructors.Publisher allows immediate open acces

Economies of Size in Non-Slaughtering Meat Processing Plants

The Oklahoma Agricultural Experiment Station periodically issues revisions to its publications. The most current edition is made available. For access to an earlier edition, if available for this title, please contact the Oklahoma State University Library Archives by email at [email protected] or by phone at 405-744-6311