Variants of the human PPARG locus and the susceptibility to chronic periodontitis

Apart from its regulatory function in lipid and glucose metabolism, peroxisome proliferator-activated receptor (PPAR)γ has impact on the regulation of inflammation and bone metabolism. The aim of the study was to investigate the association of five polymorphisms (rs10865710, rs2067819, rs3892175, rs1801282, rs3856806) within the PPARG gene with chronic periodontitis. The study population comprised 402 periodontitis patients and 793 healthy individuals. Genotyping of the PPARG gene polymorphisms was performed by PCR and melting curve analysis. Comparison of frequency distribution of genotypes between individuals with periodontal disease and healthy controls for the polymorphism rs3856806 showed a P-value of 0.04 but failed to reach significance after correction for multiple testing (P  0.90). A 3-site analysis (rs2067819-rs1801282-rs3856860) revealed five haplotypes with a frequency of ≥1% among cases and controls. Following adjustment for age, gender and smoking, none of the haplotypes was significantly different between periodontitis and healthy controls after Bonferroni correction. This study could not show a significant association between PPARG gene variants and chronic periodontitis

Personalization in object-based audio for accessibility : a review of advancements for hearing impaired listeners

Hearing loss is widespread and significantly impacts an individual’s ability to engage with broadcast media. Access can be improved through new object-based audio personalization methods. Utilizing the literature on hearing loss and intelligibility this paper develops three dimensions which are evidenced to improve intelligibility: spatial separation, speech to noise ratio and redundancy. These can be personalized, individually or concurrently, using object based audio. A systematic review of all work in object-based audio personalization is then undertaken. These dimensions are utilized to evaluate each project’s approach to personalisation, identifying successful approaches, commercial challenges and the next steps required to ensure continuing improvements to broadcast audio for hard of hearing individuals

A note on the index of closed minimal hypersurfaces of flat tori

Generalizing earlier work by Ros in ambient dimension three, we prove an affine lower bound for the Morse index of closed minimal hypersurfaces inside a flat torus in terms of their first Betti number (with purely dimensional coefficients)

Oxygen uptake estimation in humans during exercise using a Hammerstein model

This paper aims to establish a block-structured model to predict oxygen uptake in humans during moderate treadmill exercises. To model the steady state relationship between oxygen uptake (oxygen consumption) and walking speed, six healthy male subjects walked on a motor driven treadmill with constant speed from 2 to 7 km/h. The averaged oxygen uptake at steady state (VO 2) was measured by a mixing chamber based gas analysis and ventilation measurement system (AEI Moxus Metabolic Cart). Based on these reliable date, a nonlinear steady state relationship was successfully established using Support Vector Regression methods. In order to capture the dynamics of oxygen uptake, the treadmill velocity was modulated using a Pseudo Random Binary Signal (PRBS) input. Breath by breath analysis of all subjects was performed. An ARX model was developed to accurately reproduce the measured oxygen uptake dynamics within the aerobic range. Finally, a Hammerstein model was developed, which may be useful for implementing a control system for the regulation of oxygen uptake during treadmill exercises. © 2007 Biomedical Engineering Society

Heart rate control during treadmill exercise

A computer-controlled treadmill and related data collection and processing systems have been developed for the control of heart rate during treadmill exercise. Minimizing deviations of heart rate from a preset profile is achieved by controlling the speed and/or the gradient of the treadmill. A simple and practical heart rate measurement algorithm has been developed to robustly measure the variations of heart rate. Both conventional Proportional-Integral- Derivative (PID) control and fuzzy Proportional-Integral (PI) control approaches have been employed for the controller design. The fuzzy Proportional-Integral algorithm achieved better heart rate tracking performance. Finally, a heart rate based exercising protocol was successfully implemented on the newly designed exercise system. © 2005 IEEE

Analysis of orientation error of triaxial accelerometers on the assessment of energy expenditure

This paper investigates the effects of orientation error in the positioning of triaxial accelerometers on the assessment of energy expenditure. Four subjects walked on a treadmill at varying velocities ranging from 4km.h -1 to 5km.h-1. During each test, a triaxial accelerometer attached to the lower back at arbitrary orientations to record body accelerations. Energy expenditure was estimated by the sum of the integrals of the absolute value of accelerometer output from all the three measurement directions. Based on theoretical analysis and experimental observations, it is concluded that small orientation errors ( < 3° ) have no distinguishable effects on the estimation of energy expenditure. We propose an efficient method to compensate for larger orientation errors. The experimental results verified the effectiveness of this proposed compensation method. ©2005 IEEE

Obesity and perceived work discrimination in Spain

Obesity is increasingly becoming a source of discrimination in many domains of living, including at the workplace. In this study, we estimate obesity-related discrimination in work settings in Spain and explore its potential sources. We use data from the European Health Interview Survey conducted in 2009–2010. Our models control for a comprehensive set of demographic, socioeconomic, health, and work-related sickness characteristics. We run separate models for women and men, and stratify by type of occupation and by area obesity prevalence. Our results indicate that weight-related discrimination in work settings in Spain is concentrated among women with morbid obesity, particularly among those working in customer-facing jobs and living in areas with low-obesity prevalence. These findings emphasize the persistence of the gendered nature of obesity-related discrimination, and provide evidence of a form of induced statistical discrimination. Employers’ expectations of lower returns from obese workers in customer facing jobs might be driven by customers’ preferences caused by social stigma. Furthermore, the role of area-obesity prevalence highlights the impact of cultural social norms even within the same country