Myocardial bloodflow by PET: Correction for spillover and partial volume

A method, based on the a bolus H2O15 bloodflow measurement, which can correct for spillover and partial volume in position emission tomography (PET), is presented. The results of this method are compared, at least partially, to other methods, in particular the radiolabeled carbon monoxide method for predicting spillover and the use of high spatial resolution gated cardiac magnetic resonance imaging scans to predict partial volume (PV). The PV and spillover corrections derived from the 15O-water results can be used to correct for PV effects and spillover effects in the myocardial activity distribution of any other positron emitting isotope, for example 18F-deoxyglucose