Entangling two distant nanocavities via a waveguide

In this paper, we investigate the generation of continuous variable entanglement between two spatially-separate nanocavities mediated by a coupled resonator optical waveguide in photonic crystals. By solving the exact dynamics of the cavity system coupled to the waveguide, the entanglement and purity of the two-mode cavity state are discussed in detail for the initially separated squeezing inputs. It is found that the stable and pure entangled state of the two distant nanocavities can be achieved with the requirement of only a weak cavity-waveguide coupling when the cavities are resonant with the band center of the waveguide. The strong couplings between the cavities and the waveguide lead to the entanglement sudden death and sudden birth. When the frequencies of the cavities lie outside the band of the waveguide, the waveguide-induced cross frequency shift between the cavities can optimize the achievable entanglement. It is also shown that the entanglement can be easily manipulated through the changes of the cavity frequencies within the waveguide band.Comment: 8 pages, 8 figure

Geometry and optics calibration of WFCTA prototype telescopes using star light

The Large High Altitude Air Shower Observatory project is proposed to study high energy gamma ray astronomy ( 40 GeV-1 PeV ) and cosmic ray physics ( 20 TeV-1 EeV ). The wide field of view Cherenkov telescope array, as a component of the LHAASO project, will be used to study energy spectrum and compositions of cosmic ray by measuring the total Cherenkov light generated by air showers and shower maximum depth. Two prototype telescopes have been in operation since 2008. The pointing accuracy of each telescope is crucial to the direction reconstruction of the primary particles. On the other hand the primary energy reconstruction relies on the shape of the Cherenkov image on the camera and the unrecorded photons due to the imperfect connections between photomultiplier tubes. UV bright stars are used as point-like objects to calibrate the pointing and to study the optical properties of the camera, the spot size and the fractions of unrecorded photons in the insensitive areas of the camera.Comment: 5 pages, 6 figures, submitted to Chinese Physics

Local transformation of mixed states of two qubits to Bell diagonal states

The optimal entanglement manipulation for a single copy of mixed states of two qubits is to transform it to a Bell diagonal state. In this paper we derive an explicit form of the local operation that can realize such a transformation. The result obtained is universal for arbitrary entangled two-qubit states and it discloses that the corresponding local filter is not unique for density matrices with rank $n=2$ and can be exclusively determined for that with $n=3$ and 4. As illustrations, a four-parameters family of mixed states are explored, the local filter as well as the transformation probability are given explicitly, which verify the validity of the general result.Comment: 5 pages, to be published in Phys. Rev.

Improved functional expression of recombinant human ether-a-go-go (hERG) K+ channels by cultivation at reduced temperature

<p>Abstract</p> <p>Background</p> <p>HERG potassium channel blockade is the major cause for drug-induced long QT syndrome, which sometimes cause cardiac disrhythmias and sudden death. There is a strong interest in the pharmaceutical industry to develop high quality medium to high-throughput assays for detecting compounds with potential cardiac liability at the earliest stages of drug development. Cultivation of cells at lower temperature has been used to improve the folding and membrane localization of trafficking defective hERG mutant proteins. The objective of this study was to investigate the effect of lower temperature maintenance on wild type hERG expression and assay performance.</p> <p>Results</p> <p>Wild type hERG was stably expressed in CHO-K1 cells, with the majority of channel protein being located in the cytoplasm, but relatively little on the cell surface. Expression at both locations was increased several-fold by cultivation at lower growth temperatures. Intracellular hERG protein levels were highest at 27°C and this correlated with maximal ³H-dofetilide binding activity. In contrast, the expression of functionally active cell surface-associated hERG measured by patch clamp electrophysiology was optimal at 30°C. The majority of the cytoplasmic hERG protein was associated with the membranes of cytoplasmic vesicles, which markedly increased in quantity and size at lower temperatures or in the presence of the Ca²⁺-ATPase inhibitor, thapsigargin. Incubation with the endocytic trafficking blocker, nocodazole, led to an increase in hERG activity at 37°C, but not at 30°C.</p> <p>Conclusion</p> <p>Our results are consistent with the concept that maintenance of cells at reduced temperature can be used to boost the functional expression of difficult-to-express membrane proteins and improve the quality of assays for medium to high-throughput compound screening. In addition, these results shed some light on the trafficking of hERG protein under these growth conditions.</p

Geometrical structure effect on localization length of carbon nanotubes

The localization length and density of states of carbon nanotubes are evaluated within the tight-binding approximation. By comparison with the corresponding results for the square lattice tubes, it is found that the hexagonal structure affects strongly the behaviors of the density of states and localization lengths of carbon nanotubes.Comment: 7 pages, 4 figures, revised version to appear in Chin. Phys. Lett. The title is changed. Some arguments are adde

Mandibulofacial Dysostosis Attributed to a Recessive Mutation of CYP26C1 in Hereford Cattle

In spring 2020, six Hereford calves presented with congenital facial deformities attributed to a condition we termed mandibulofacial dysostosis (MD). Affected calves shared hallmark features of a variably shortened and/or asymmetric lower mandible and bilateral skin tags present 2–10 cm caudal to the commissure of the lips. Pedigree analysis revealed a single common ancestor shared by the sire and dam of each affected calf. Whole-genome sequencing (WGS) of 20 animals led to the discovery of a variant (Chr26 g. 14404993T\u3eC) in Exon 3 of CYP26C1 associated with MD. This missense mutation (p.L188P), is located in an α helix of the protein, which the identified amino acid substitution is predicted to break. The implication of this mutation was further validated through genotyping 2 additional affected calves, 760 other Herefords, and by evaluation of available WGS data from over 2500 other individuals. Only the a_ected individuals were homozygous for the variant and all heterozygotes had at least one pedigree tie to the suspect founder. CYP26C1 plays a vital role in tissue-specific regulation of retinoic acid (RA) during embryonic development. Dysregulation of RA can result in teratogenesis by altering the endothelin-1 signaling pathway affecting the expression of Dlx genes, critical to mandibulofacial development. We postulate that this recessive missense mutation in CYP26C1 impacts the catalytic activity of the encoded enzyme, leading to excess RA resulting in the observed MD phenotype

Twist-3 Distribute Amplitude of the Pion in QCD Sum Rules

We apply the background field method to calculate the moments of the pion two-particles twist-3 distribution amplitude (DA) $\phi_p(\xi)$ in QCD sum rules. In this paper,we do not use the equation of motion for the quarks inside the pion since they are not on shell and introduce a new parameter $m_0^p$ to be determined. We get the parameter $m_0^p\approx1.30GeV$ in this approach. If assuming the expansion of $\phi_p(\xi)$ in the series in Gegenbauer polynomials $C_n^{1/2}(\xi)$, one can obtain its approximate expression which can be determined by its first few moments.Comment: 12 pages, 3 figure

Quantum Theory Approach for Neutron Single and Double-Slit Diffraction

We provide a quantum approach description of neutron single and double-slit diffraction, with specific attention to the cold neutron diffraction ($\lambda \approx 20$\AA) carried out by Zeilinger et al. in 1988. We find the theoretical results are good agreement with experimental data.Comment: 10 page