10 research outputs found
Feed intake and weight and body condition changes of 100% organically fed lactating sows
Energy and protein density of the 100 % organic lactation diet should be increased as early as from 3rd week of lactation onwards in order to minimize the weight loss of the sow during the at least 40 day lactation period. Feed amino acid balance from 22nd day of lactation should match the amount of live weight lost during the first 21 days of lactation. This should be supported by providing the piglets feed attractive enough to ensure their high dry feed intake during the late lactation period
Uudet hankkeet - ICOPP
Paikallisten rehujen hyödyntämistä sikojen ja siipikarjan luomurokinnassa tutkitaan yhteiseuroopalaisessa luomuhanke ICOPP:ssa. Hankkeessa päivitetään suomalaistenkin luomusikojen ja – siipikarjan rehustusmahdollisuuksia
Influence of crate height during slaughter transport on the welfare of male turkeys
v2012o
Gene activation of CEBPA using saRNA: preclinical studies of the first in human saRNA drug candidate for liver cancer
Identification of the possible therapeutic targets in the insulin-like growth factor 1 receptor pathway in a cohort of Egyptian hepatocellular carcinoma complicating chronic hepatitis C type 4
The effect of deep pectoral myopathy on the properties of broiler chicken muscles characterised by selected instrumental techniques
The expression and construction of engineering Escherichia coli producing humanized AluY RNAs
RNA activation
The ability to manipulate gene expression is invaluable for understanding the molecular pathogenesis of disease as well as for developing novel therapeutics. RNA interference provides a robust platform for the knockdown of a specific gene at the post-transcriptional level, but activation of specific genes traditionally has been limited to ligand-mediated activation of signal transduction pathways or introduction of exogenous transgenes from expression vectors. Recent work has shown that small RNA molecules targeted to the promoter region of a gene can activate gene expression. This phenomenon, called RNA activation, provides a tool for specific activation of endogenous genes, and introduces a new role for noncoding RNAs in the regulation of gene expression. These small RNAs are typically 21-nucleotide duplexes, and have been shown to activate a wide variety of genes in many cell types and across species. The application of this technology will prove invaluable for basic research through gain-of-function studies and potentially targeted gene activation for disease intervention. This chapter will cover what is currently defined on the mechanism of RNA activation, and will explore the possible application of this technology for novel therapeutics