1,603 research outputs found
External bioelectrodes - A battery substitute for biological telemetry systems Final report, period ending 28 Feb. 1966
Electrode pair power output in saline and on skin for determination of telemetry system power source material
Multi-field open inflation model and multi-field dynamics in tunneling
We consider a multi-field open inflation model, in which one of the fields
dominates quantum tunneling from a false vacuum while the other field governs
slow-roll inflation within the bubble nucleated from false vacuum decay. We
call the former the tunneling field and the latter the inflaton field. In the
limit of a negligible interaction between the two fields, the false vacuum
decay is described by a Coleman-De Luccia instanton. Here we take into account
the coupling between the two fields and construct explicitly a multi-field
instanton for a simple quartic potential model. We also solve the evolution of
the scalar fields within the bubble. We find our model realizes open inflation
successfully. This is the first concrete, viable model of open inflation
realized with a simple potential. We then study the effect of the multi-field
dynamics on the false vacuum decay, specifically on the tunneling rate. We find
the tunneling rate increases in general in comparison with the single field
case, though the increase is small unless the inflaton affects the instanton
solution substantially.Comment: 13 pages, 4 figure
Exploring a string-like landscape
We explore inflationary trajectories within randomly-generated
two-dimensional potentials, considered as a toy model of the string landscape.
Both the background and perturbation equations are solved numerically, the
latter using the two-field formalism of Peterson and Tegmark which fully
incorporates the effect of isocurvature perturbations. Sufficient inflation is
a rare event, occurring for only roughly one in potentials. For models
generating sufficient inflation, we find that the majority of runs satisfy
current constraints from WMAP. The scalar spectral index is less than 1 in all
runs. The tensor-to-scalar ratio is below the current limit, while typically
large enough to be detected by next-generation CMB experiments and perhaps also
by Planck. In many cases the inflationary consistency equation is broken by the
effect of isocurvature modes.Comment: 24 pages with 8 figures incorporated, matches version accepted by
JCA
“Exploring the Basement of Social Justice Issues”: A Graduate Upon Graduation
Photograph of rides building up, taken J. Stevens' Fair, 20 June 1961 whole general view, looking West. See Leeson's notebook 9, pages 92-95 for notes
Precision medicine approaches for diabetic kidney disease:opportunities and challenges
The prevalence of end-stage kidney disease (ESKD) continuously increases worldwide. The increasing prevalence parallels the growth in the number of people with diabetes, which is the leading cause of ESKD. Early diagnosis of chronic kidney disease (CKD) in patients with diabetes and appropriate intervention is important to delay the progression of kidney function decline and prevent ESKD. Rate of CKD progression and response to treatment varies among patients with diabetes, highlighting the need to tailor individual treatment. In this review, we describe recent advances and areas for future studies with respect to precision medicine in diabetic kidney disease (DKD). DKD is a multi-factorial disease that is subject in part to genetic heritability, but is also influenced by various exogenous mediators, such as environmental or dietary factors. Genetic testing so far has limited utility to facilitate early diagnosis, classify progression or evaluate response to therapy. Various biomarker-based approaches are currently explored to identify patients at high risk of ESKD and to facilitate decision-making for targeted therapy. These studies have led to discovery and validation of a couple of inflammatory proteins such as circulating tumour necrosis factor receptors, which are strong predictors of kidney disease progression. Moreover, risk and drug-response scores based on multiple biomarkers are developed to predict kidney disease progression and long-term drug efficacy. These findings, if implemented in clinical practice, will pave the way to move from a one-size-fits-all to a one-fit-for-everyone approach
Accelerating universe emergent from the landscape
We propose that the existence of the string landscape suggests the universe
can be in a quantum glass state, where an extremely large viscosity is
generated, and long distance dynamics slows down. At the same time, the short
distance dynamics is not altered due to the separation of time scales. This
scenario can help to understand some controversies in cosmology, for example
the natural existence of slow roll inflation and dark energy in the landscape,
the apparent smallness of the cosmological constant. We see also that moduli
stabilization is no longer necessary. We further identify the glass transition
point, where the viscosity diverges, as the location of the cosmic horizon. We
try to reconstruct the geometry of the accelerating universe from the structure
of the landscape, and find that the metric should have an infinite jump when
crossing the horizon. We predict that the static coordinate metric for dS space
breaks down outside the horizon.Comment: 20 pages, no figures, harvma
Brane Inflation and the Overshoot Problem
We investigate recent claims that brane inflation solves the overshoot
problem through a combination of microphysical restrictions on the phase space
of initial conditions and the existence of the Dirac-Born-Infeld (DBI)
attractor in regimes where the slow-roll attractor does not apply. Carrying out
a comprehensive analysis of the parameter space allowed by the latest advances
in brane inflation model-building, we find that these restrictions are
insufficient to solve the overshoot problem. The vast majority of the phase
space of initial conditions is still dominated by overshoot trajectories. We
present an analytic proof that the brane-inflationary attractor must be close
to the slow-roll limit, and update the predictions for observables such as
non-Gaussianity, cosmic string tension and tensor modes.Comment: 14 pages, 3 figures, matches version published in PRD. Minor
clarifications, references adde
Cosmology of the Tachyon in Brane Inflation
In certain implementations of the brane inflationary paradigm, the exit from
inflation occurs when the branes annihilate through tachyon condensation. We
investigate various cosmological effects produced by this tachyonic era. We
find that only a very small region of the parameter space (corresponding to
slow-roll with tiny inflaton mass) allows for the tachyon to contribute some
e-folds to inflation. In addition, non-adiabatic density perturbations are
generated at the end of inflation. When the brane is moving relativistically
this contribution can be of the same order as fluctuations produced 55 e-folds
before the end of inflation. The additional contribution is very nearly
scale-invariant and enhances the tensor/scalar ratio. Additional
non-gaussianities will also be generated, sharpening current constraints on
DBI-type models which already predict a significantly non-gaussian signal.Comment: 30 pages, 2 figures; v3, minor revision, JCAP versio
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