Reflectance Confocal Microscopy for the Diagnosis of Galli-Galli Disease

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Rudimentary meningocele: remnant of a neural tube defect?

Background: Rudimentary meningocele, a malformation in which meningothelial elements are present in the skin and subcutaneous tissue, has been described in the past, under a variety of different terms and has also been referred to as cutaneous meningioma. There has been debate as to whether rudimentary meningocele is an atretic form of meningocele or results from growth of meningeal cells displaced along cutaneous nerve

Eruptive Epidermoidzysten nach Imiquimod-Therapie eines rezidivierenden Basalzellkarzinoms : Ein Fallbericht

Eruptive Epidermoidzysten stellen eine seltene Nebenwirkung von Imiquimod zur Behandlung von Basalzellkarzinomen dar. Bis dato wurden 8 F\ue4lle in der Literatur beschrieben. Wir pr\ue4sentieren den Fall einer 75-j\ue4hrigen kaukasischen Patientin mit einem 8\u2011mal rezidivierten Basalzellkarzinom der Nase. Nach mehrfachen Exzisionen und Therapie mit Vismodegib erhielt die Patientin schlie flich Imiquimod 5\u202f% Creme in der Standarddosierung 5\u2011mal w\uf6chentlich f\ufcr die Dauer von 6 Wochen. Zwei Monate nach dem Absetzen von Imiquimod zeigten sich eruptive Epidermoidzysten

Eruptive Epidermoidzysten nach Imiquimod-Therapie eines rezidivierenden Basalzellkarzinoms : Ein Fallbericht

Eruptive Epidermoidzysten stellen eine seltene Nebenwirkung von Imiquimod zur Behandlung von Basalzellkarzinomen dar. Bis dato wurden 8 F\ue4lle in der Literatur beschrieben. Wir pr\ue4sentieren den Fall einer 75-j\ue4hrigen kaukasischen Patientin mit einem 8\u2011mal rezidivierten Basalzellkarzinom der Nase. Nach mehrfachen Exzisionen und Therapie mit Vismodegib erhielt die Patientin schlie flich Imiquimod 5\u202f% Creme in der Standarddosierung 5\u2011mal w\uf6chentlich f\ufcr die Dauer von 6 Wochen. Zwei Monate nach dem Absetzen von Imiquimod zeigten sich eruptive Epidermoidzysten

Solitary skin lesions with histopathologic features of early mycosis fungoides

Mycosis fungoides (MF) is a cutaneous T-cell lymphoma that usually begins with cutaneous patches that evolve into plaques and tumors. A few recent reports describe a solitary variant of MF distinct from localized pagetoid reticulosis, a disease in which solitary verrucous lesions occur on acral skin. Solitary skin lesions with some of the histopathologic features of MF rarely occur during treatment with several drugs, especially antidepressants or antihistamines. We analyzed the clinicopathologic features of 20 patients with solitary skin lesions showing histopathologic features of patch- or early plaque-stage MF. Eight men and 12 women (mean age 50.6, range 23-82, median 49) had solitary, small erythematous patches or plaques located on the trunk (16 cases, 6 of them on the breast), upper extremities (3 cases), and inguinal region (1 case). Ten patients were treated with one or more drugs; only two of them received antidepressants or antihistamines. Histopathologic examination revealed in all cases a band-like infiltrate in the upper dermis, frequently with epidermotropism of solitary lymphocytes. Atypical lymphocytes were present in a minority of cases. Immunohistology showed a predominance of CD3+ T lymphocytes, in most cases admired with clusters of CD20+ B-cells. Only a small proportion of the infiltrate was CD8+. Molecular analysis of the rearrangement of the T-cell receptor genes was performed in 16 cases using the polymerase chain reaction (PCR) technique and revealed a monoclonal band in 8 of them. After surgical excision, 2/14 patients had a recurrence near the surgical scar. In 18 patients with complete follow-up data, no evidence of "classic" MF could be observed after a mean follow-up of 31.9 months. Solitary skin lesions with the histopathologic features of MF can be considered as a distinct clinicopathologic entity, probably representing a solitary variant of mycosis fungoides

Angioinvasive Lymphomatoid Papulosis

Lymphomatoid papulosis (LyP) is a chronic recurrent lymphoproliferative disorder characterized clinically by self-regressing cutaneous lesions. Histologically, it is recognized by clusters of CD30 atypical lymphocytes in the background of mixed inflammatory infiltrate. It has been classified as type A, B, C, and D. Recently, a further variant of LyP was described as "angioinvasive LyP" in a series of 16 patients. We report a case of a 73-year-old female presenting with papules and nodules on the extremities evolving into eschar-like necrotic plaques. Histological examination revealed medium- to large-sized atypical lymphoid CD30 cells densely infiltrating the dermis with distinct angioinvasion and angiodestruction. No systemic involvement was identified. The clinicopathologic features conformed to the newly described angioinvasive LyP