Candidate technologies for high-capacity optical communication systems

The practicalities in designing high-capacity optical communication systems are described. With a given perspective on the present and future technologies, we cover the transceiver design and optical amplifier technologies to maximize optical fiber capacity. OCIS codes:

P02-07. High Concentrations of Interleukin-15 and Low Concentrations of CCL5 in Breast Milk are Associated with Protection against Postnatal HIV Transmission

Background: Natural variations in IL-15 concentration have not been investigated for an association with an immune-protection against HIV. Given IL-15's central role in anti-HIV immunity, we hypothesized that higher concentrations of IL-15 in breast milk may protect against postnatal mother-to-child HIV transmission. Methods: In a case-control study nested within a clinical trial in Zambia, we compared IL-15 concentrations in breast milk of 22 HIV-infected women who transmitted HIV to their infants through breastfeeding with those of 72 who did not, as well as 18 HIV-uninfected women. Breast milk HIV RNA quantity, sodium, CXCL12, CCL5, and IL-8 concentrations were measured as well as maternal plasma HIV RNA concentrations and CD4 cell count. We used logistic regression modeling to adjust for potential confounders. Results: Higher concentrations of IL-15 in breast milk (adjusted odds ratio [AOR]: 0.01 per log10 pg/ml increase, 95% confidence interval [CI]: <0.001 to 0.3) were associated with protection against postnatal HIV transmission in univariate analysis and after adjusting for maternal CD4 cell counts, breast milk HIV RNA, CCL5, CXCL12, and IL-8 concentrations. Breast milk IL-15 concentration correlated with breast milk sodium, the other cytokines and HIV RNA concentration. It was inversely correlated with infant birth weight and tended to be higher in 1 week than in 1 month post-partum samples. Breast milk CCL5 concentrations were associated with increased risk of HIV transmission (AOR: 12.7 95% CI: 1.6 to 102.0) in adjusted analysis. Breast milk CXCL12 and IL-8 concentrations were not independently associated with transmission. Conclusion: High concentration of IL-15 were associated with a protection against breastfeeding HIV transmission after adjusting for other pro-inflammatory cytokines, HIV RNA in breast milk, and maternal CD4 cell count. These results corroborate a protective role of IL-15-mediated cellular immunity against HIV transmission during breastfeeding. They are informative for vaccination studies using IL-15 as an adjuvant

Digital back-propagation for nonlinearity mitigation in distributed Raman amplified links

The performance of digital back-propagation (DBP) for distributed Raman amplified optical communication systems is evaluated through analytical models and numerical simulations, and is compared with conventional lumped amplifier solutions, such as EDFA. The complexity of the DBP algorithm including the characteristic signal power profile of distributed Raman amplifiers is assessed. The use of full-field DBP in distributed Raman amplified systems leads to 1.3 dB additional gain with respect to systems employing lumped amplification, at the cost of only a 25% increase in complexity

On the bandwidth dependent performance of split transmitter-receiver optical fiber nonlinearity compensation

The Gaussian noise model is used to estimate the performance of three digital nonlinearity compensation (NLC) algorithms in C-band, long-haul, optical fiber transmission, when the span length and NLC bandwidth are independently varied. The algorithms are receiver-side digital backpropagation (DBP), transmitter-side DBP (digital precompensation), and Split NLC (an equal division of DBP between transmitter and receiver). For transmission over 100×100 km spans, the model predicts a 0.2 dB increase in SNR when applying Split NLC (versus DBP) to a single 32 GBd channel (from 0.4 dB to 0.6 dB), monotonically increasing with NLC bandwidth up to 1.6 dB for full-field NLC. The underlying assumptions of this model and the practical considerations for implementation of Split NLC are discussed. This work demonstrates, theoretically, that, regardless of the transmission scenario, it is always beneficial to divide NLC between transmitter and receiver, and identifies the transmission regimes where Split NLC is particularly advantageous

Impact of Transceiver Subsystems on Digital Back Propagation Performance

The potential, limitations and practicalities of digital back propagation is investigated in the presence of noise arising from amplifier spontaneous emission noise a well as from a nonideal transceiver subsystem

Investigation of bandwidth loading in optical fibre transmission using amplified spontaneous emission noise

The use of spectrally shaped amplified spontaneous emission noise (SS-ASE) as a method for emulating interfering channels in optical fibre transmission systems has been studied. It is shown that the use of SS-ASE leads to a slightly pessimistic performance relative to the use of conventionally modulated interfering channels in the nonlinear regime. The additional nonlinear interference noise (on the channel under test), due to the Gaussian nature of SS-ASE, has been calculated using a combination of the Gaussian noise (GN) and enhanced GN (EGN) models for the entire C-band (4.5 THz) and experimentally shown to provide a lower bound for transmission performance

Designable electron transport features in one-dimensional arrays of metallic nanoparticles: Monte Carlo study of the relation between shape and transport

We study the current and shot noise in a linear array of metallic nanoparticles taking explicitly into consideration their discrete electronic spectra. Phonon assisted tunneling and dissipative effects on single nanoparticles are incorporated as well. The capacitance matrix which determines the classical Coulomb interaction within the capacitance model is calculated numerically from a realistic geometry. A Monte Carlo algorithm which self-adapts to the size of the system allows us to simulate the single-electron transport properties within a semiclassical framework. We present several effects that are related to the geometry and the one-electron level spacing like e.g. a negative differential conductance (NDC) effect. Consequently these effects are designable by the choice of the size and arrangement of the nanoparticles.Comment: 13 pages, 12 figure

Oral vinorelbine and cisplatin with concomitant radiotherapy in stage III non-small cell lung cancer (NSCLC): A feasibility study

Background: Concurrent chemoradiotherapy has improved survival in inoperable stage III non-small cell lung cancer (NSCLC). This phase I trial was performed in order to establish a dose recommendation for oral vinorelbine in combination with cisplatin and simultaneous radiotherapy. Patients and Methods: Previously untreated patients with stage IIIB NSCLC received concurrent chemoradiotherapy with 66 Gy and 2 cycles of cisplatin and oral vinorelbine which was administered at 3 different levels (40, 50 and 60 mg/m(2)). This was to be followed by 2 cycles of cisplatin/vinorelbine oral consolidation chemotherapy. The study goal was to determine the maximal recommended dose of oral vinorelbine during concurrent treatment. Results: 11 stage IIIB patients were entered into the study. The median radiotherapy dose was 66 Gy. Grade 3-4 toxicity included neutropenia, esophagitis, gastritis and febrile neutropenia. The dose-limiting toxicity for concurrent chemoradiotherapy was esophagitis. 9 patients received consolidation chemotherapy, with neutropenia and anemia/thrombocytopenia grade 3 being the only toxicities. The overall response was 73%. Conclusion: Oral vinorelbine 50 mg/m(2) (days 1, 8, 15 over 4 weeks) in combination with cisplatin 20 mg/m2 (days 1-4) is the recommended dose in combination with radiotherapy (66 Gy) and will be used for concurrent chemoradiotherapy in a forthcoming phase III trial testing the efficacy of consolidation chemotherapy in patients not progressing after chemoradiotherapy

The Impact of Transceiver Noise on Digital Nonlinearity Compensation

The efficiency of digital nonlinearity compensation (NLC) is analyzed in the presence of noise arising from amplified spontaneous emission noise (ASE) as well as from a non-ideal transceiver subsystem. Its impact on signal-to-noise ratio (SNR) and reach increase is studied with particular emphasis on split NLC, where the digital back-propagation algorithm is divided between transmitter and receiver. An analytical model is presented to compute the SNR's for non-ideal transmission systems with arbitrary split NLC configurations. When signal-signal nonlinearities are compensated, the performance limitation arises from residual signal-noise interactions. These interactions consist of nonlinear beating between the signal and co-propagating ASE and transceiver noise. While transceiver noise-signal beating is usually dominant for short transmission distances, ASE noise-signal beating is dominant for larger transmission distances. It is shown that both regimes behave differently with respect to the optimal NLC split ratio and their respective reach gains. Additionally, simple formulas for the prediction of the optimal NLC split ratio and the reach increase in those two regimes are reported. It is found that split NLC offers negligible gain with respect to conventional digital back-propagation ()DBP for distances less than 1000 km using standard single-mode fibers and a transceiver (back-to-back) SNR of 26 dB, when transmitter and receiver inject the same amount of noise. However, when transmitter and receiver inject an unequal amount of noise, reach gains of 56% on top of DBP are achievable by properly tailoring the split NLC algorithm. The theoretical findings are confirmed by numerical simulations

Achievable information rates estimation for 100-nm ramana amplified optical transmission system

The achievable information rates of optical communication systems using ultra-wide bandwidth 100-nm distributed Raman amplification have been investigated for each individual subchannels, based on the first-order perturbative analysis of nonlinear distortions