Expression of platelet-derived growth factor-beta receptor and bovine papillomavirus E5 and E7 oncoproteins in equine sarcoid.

Equine sarcoids are benign fibroblastic skin tumours that are recognized throughout the world. Infection with bovine papillomavirus (BPV) types 1 and 2 has been implicated as a major factor in disease development; however, the cellular mechanisms underlying fibroblast transformation remain poorly defined. The present study further characterizes aspects of the association with BPV in 15 equine sarcoids. BPV DNA was demonstrated in 12/15 tumours collected from different areas of Italy. Nine of these 12 tumours expressed the BPV oncoproteins E5 and E7, but these oncoproteins were not expressed by normal equine cells. The BPV E5 protein is known to bind to the platelet-derived growth factor-b receptor (PDGF-bR) and this molecule was expressed by 11 of the 12 sarcoids in which E5 was demonstrated. These findings add further weight to the theory that BPV and the PDGF-bR may have a role in the pathogenesis of this disease

Cosmological solutions in generalized hybrid metric-Palatini gravity

We construct exact solutions representing a Friedmann-Lema\^itre-Robsertson-Walker (FLRW) universe in a generalized hybrid metric-Palatini theory. By writing the gravitational action in a scalar-tensor representation, the new solutions are obtained by either making an ansatz on the scale factor or on the effective potential. Among other relevant results, we show that it is possible to obtain exponentially expanding solutions for flat universes even when the cosmology is not purely vacuum. We then derive the classes of actions for the original theory which generate these solutions.Comment: 14 pages, 17 figure

04/07/2010 - Koresh Dance Company.pdf

Simultaneous and multipoint assessment of vibration velocities is an important issue for the development of advanced noncontact vibrometers. In this article a novel fiber optic vibrometer is presented. The architecture of the sensor is based on a simple optical layout and it is characterized by multiple fiber optic interferometric sensors which are operated in the homodyne mode. Optical configuration and operation of the single-point version of the sensor, as well as the two-points measurement version, are described and typical measured signals with the operating range are shown. The sensor can easily be configured in order to perform a higher number of point measurements. Some details regarding signal acquisition and processing are also given and the ways in which Doppler demodulation is performed are discussed. Finally tests with sinusoidal target excitation in the range 0–1.8 kHz have been conducted

Strain Transfer in Surface-Bonded Optical Fiber Sensors

Fiber optic sensors represent one of the most promising technologies for the monitoring of various engineering structures. A major challenge in the field is to analyze and predict the strain transfer to the fiber core reliably. Many authors developed analytical models of a coated optical fiber, assuming null strain at the ends of the bonding length. However, this configuration only partially reflects real experimental setups in which the cable structure can be more complex and the strains do not drastically reduce to zero. In this study, a novel strain transfer model for surface-bonded sensing cables with multilayered structure was developed. The analytical model was validated both experimentally and numerically, considering two surface-mounted cable prototypes with three different bonding lengths and five load cases. The results demonstrated the capability of the model to predict the strain profile and, differently from the available strain transfer models, that the strain values at the extremities of the bonded fiber length are not null

Effects of thermal cycles on interfacial pressure in MV cable joints

The use of medium voltage cable joints is mandatory when dealing with power cable faults and the installation of new lines. However, such an accessory is among the top causes of faults among the grid. To this purpose, one of the quantities monitored to understand the causes of such faults is the interfacial pressure between the insulating layers of the cable joint. In this work, the interfacial pressure between Cross-linked polyethylene (XLPE) and silicon rubber has been evaluated when the cable joint experiences thermal cycles. From the results, the pressure variation caused by the thermal cycles is demonstrated. Such a phenomenon may be connected to the generation of voids and weak spots that accelerate cable joint ageing. Therefore, proper comments and conclusions are drawn

The evolution of tensor perturbations in scalar-tensor theories of gravity

The evolution equations for tensor perturbations in a generic scalar tensor theory of gravity are presented. Exact solution are given for a specific class of theories and Friedmann-Lema\^{i}tre-Robertson-Walker backgrounds. In these cases it is shown that, although the evolution of tensor models depends on the choice of parameters of the theory, no amplification is possible if the gravitational interaction is attractive.Comment: 11 pages, 2 figures, submitted to Physical Review

Classification Systems for Knee Osteochondritis Dissecans: A Systematic Review

Objective Aim of this systematic review was to describe all classification systems for knee osteochondritis dissecans (OCD) lesions, evaluating their accuracy and reliability, as well as their use in the literature on knee OCD. Design A systematic review of the literature was performed in July 2021 on PubMed, WebOfScience, and Cochrane Collaboration (library) to describe all published classification systems for knee OCD lesions and quantify the use of these classifications in the literature. Results Out of 1,664 records, 30 studies on 33 OCD classifications systems were identified, describing 11 radiographic, 13 MRI, and 9 arthroscopic classifications. The search included 193 clinical studies applying at least one OCD classification, for a total of 7,299 knee OCD cases. Radiographic classifications were applied to 35.8%, MRI to 35.2%, and arthroscopic classifications to 64.2% of the included studies. Among these, in the last two decades, the International Cartilage Repair Society's (ICRS) arthroscopic classification was the most described approach in studies on knee OCD. Overall, there is a lack of data on accuracy and reliability of the available systems. Conclusions Several classifications are available, with ICRS being the most used system over the time period studied. Arthroscopy allows to confirm lesion stability, but noninvasive imaging approaches are the first line to guide patient management. Among these, radiographic classifications are still widely used, despite being partially superseded by MRI, because of its capability to detect the earliest disease stages and to distinguish stable from unstable lesions, and thus to define the most suitable conservative or surgical approach to manage patients affected by knee OCD

A Model-Assisted Probability of Detection Framework for Optical Fiber Sensors

Optical fiber sensors (OFSs) represent an efficient sensing solution in various structural health monitoring (SHM) applications. However, a well-defined methodology is still missing to quantify their damage detection performance, preventing their certification and full deployment in SHM. In a recent study, the authors proposed an experimental methodology to qualify distributed OFSs using the concept of probability of detection (POD). Nevertheless, POD curves require considerable testing, which is often not feasible. This study takes a step forward, presenting a model-assisted POD (MAPOD) approach for the first time applied to distributed OFSs (DOFSs). The new MAPOD framework applied to DOFSs is validated through previous experimental results, considering the mode I delamination monitoring of a double-cantilever beam (DCB) specimen under quasi-static loading conditions. The results show how strain transfer, loading conditions, human factors, interrogator resolution, and noise can alter the damage detection capabilities of DOFSs. This MAPOD approach represents a tool to study the effects of varying environmental and operational conditions on SHM systems based on DOFSs and for the design optimization of the monitoring system

Comparative mapping of the fragile histidine triad (FHIT) gene in cattle, river buffalo, sheep and goat by FISH and assignment to BTA22 by RH-mapping: a comparison with HSA3

Common fragile sites can be damaged by exposure to a variety of carcinogens. The fragile histidine triad (FHIT) gene, including the most active human chromosomal fragile site (FRA3B) at chromosome band HSA3p14.2,1 has been proposed as a tumour suppressor gene for a variety of tumours.2 The most common response to carcinogen exposure is deletions at the FHIT locus that alter the gene structure and function. In this study we assign the FHIT gene in cattle, river buffalo, sheep and goat chromosomes by comparative fluorescence in situ hybridization (FISH)-mapping. In addition, the assignment to BTA22 was confirmed by typing the marker across a bovine radiation hybrid (RH) panel