38 research outputs found
Ground state at high density
Weak limits as the density tends to infinity of classical ground states of
integrable pair potentials are shown to minimize the mean-field energy
functional. By studying the latter we derive global properties of high-density
ground state configurations in bounded domains and in infinite space. Our main
result is a theorem stating that for interactions having a strictly positive
Fourier transform the distribution of particles tends to be uniform as the
density increases, while high-density ground states show some pattern if the
Fourier transform is partially negative. The latter confirms the conclusion of
earlier studies by Vlasov (1945), Kirzhnits and Nepomnyashchii (1971), and
Likos et al. (2007). Other results include the proof that there is no Bravais
lattice among high-density ground states of interactions whose Fourier
transform has a negative part and the potential diverges or has a cusp at zero.
We also show that in the ground state configurations of the penetrable sphere
model particles are superposed on the sites of a close-packed lattice.Comment: Note adde
Spectra of Discrete Schr\"odinger Operators with Primitive Invertible Substitution Potentials
We study the spectral properties of discrete Schr\"odinger operators with
potentials given by primitive invertible substitution sequences (or by Sturmian
sequences whose rotation angle has an eventually periodic continued fraction
expansion, a strictly larger class than primitive invertible substitution
sequences). It is known that operators from this family have spectra which are
Cantor sets of zero Lebesgue measure. We show that the Hausdorff dimension of
this set tends to as coupling constant tends to . Moreover, we
also show that at small coupling constant, all gaps allowed by the gap labeling
theorem are open and furthermore open linearly with respect to .
Additionally, we show that, in the small coupling regime, the density of states
measure for an operator in this family is exact dimensional. The dimension of
the density of states measure is strictly smaller than the Hausdorff dimension
of the spectrum and tends to as tends to
Commensurate and incommensurate correlations in Haldane gap antiferromagnets
We analyze the onset of incommensurabilities around the VBS point of the S=1
bilinear-biquadratic model. We propose a simple effective field theory which is
capable of reproducing all known properties of the commensurate-incommensurate
transition at the disorder point . Moreover, the theory
predicts another special point , distinct from the VBS
point, where the Haldane gap behaves singularly. The ground state energy
density is an analytic function of the model parameters everywhere, thus we do
not have phase transitions in the conventional sense.Comment: 8 pages, 2 figures, to appear in PR
Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer
BACKGROUND: Trastuzumab, a recombinant monoclonal antibody against HER2, has clinical activity in advanced breast cancer that overexpresses HER2. We investigated its efficacy and safety after excision of early-stage breast cancer and completion of chemotherapy. METHODS: This international, multicenter, randomized trial compared one or two years of trastuzumab given every three weeks with observation in patients with HER2-positive and either node-negative or node-positive breast cancer who had completed locoregional therapy and at least four cycles of neoadjuvant or adjuvant chemotherapy. RESULTS: Data were available for 1694 women randomly assigned to two years of treatment with trastuzumab, 1694 women assigned to one year of trastuzumab, and 1693 women assigned to observation. We report here the results only of treatment with trastuzumab for one year or observation. At the first planned interim analysis (median follow-up of one year), 347 events (recurrence of breast cancer, contralateral breast cancer, second nonbreast malignant disease, or death) were observed: 127 events in the trastuzumab group and 220 in the observation group. The unadjusted hazard ratio for an event in the trastuzumab group, as compared with the observation group, was 0.54 (95 percent confidence interval, 0.43 to 0.67; P<0.0001 by the log-rank test, crossing the interim analysis boundary), representing an absolute benefit in terms of disease-free survival at two years of 8.4 percentage points. Overall survival in the two groups was not significantly different (29 deaths with trastuzumab vs. 37 with observation). Severe cardiotoxicity developed in 0.5 percent of the women who were treated with trastuzumab. CONCLUSIONS: One year of treatment with trastuzumab after adjuvant chemotherapy significantly improves disease-free survival among women with HER2-positive breast cancer. (ClinicalTrials.gov number, NCT00045032.)published_or_final_versio