9 research outputs found
Level of Retinol Deposit and Cervical Cancer
Objective: To analyze level of retinol deposit sufficiency in the
natural history of cervical cancer.
Methods: Serum retinol level was measured by ELISA from
peripheral blood of subjects with normal cervix, cleared and
persistent high risk human papilloma virus (HR-HPV) subclinical
infection, and cervical cancer who fulfilled the inclusion and
exclusion criteria. The study was held in Dr. Cipto Mangunkusumo
and Fatmawati Hospital, Jakarta, within 2 years (August 2013-
2015). Blood was taken twice, consisting of post-8-hour fasting
blood and 2 hours after 6000 IU retinyl palmitate oral
administration.
Results: Of 47 total samples, sufficient level of retinol deposit in
normal cervix, cleared and persistent HR-HPV subclinical infection,
and cervical cancer group was 85.0% (reference), 75.0% (OR 1.89),
33.3% (OR 11.33), and 75% (OR 1.89); respectively. Statistically,
there was no significant difference from sufficiency level of retinol
deposit between normal cervix and clearance HR-HPV subclinical
infection (p=0.628), normal cervix and persistent HR-HPV
subclinical infection (p=0.078), normal cervix and cervical cancer
(p=0.433), cervical cancer and clearance HR-HPV subclinical
infection (p=1.000), cervical cancer and persistent HR-HPV
subclinical infection (p=0.430), persistent and clearance HR-HPV
subclinical infection group (p=0.740).
Conclusion: This study proves that normal cervix group has the
highest level of retinol deposit sufficiency; however, it cannot
be stated that cervical cancer group has less sufficiency level.
Persistent HR-HPV subclinical infection group has the lowest
level of retinol deposit (OR 11.33). There is no association
between sufficient level of retinol deposit and clearance of
HR-HPV.
[Indones J Obstet Gynecol 2017; 5-1: 46-54]
Keywords: cervical cancer, HR-HPV clearance, retinol deposi
Single-visit approach of cervical cancer screening: See and Treat in Indonesia
BACKGROUND: We performed a cross-sectional study in Indonesia to evaluate the performance of a single-visit approach of cervical cancer screening, using visual inspection with acetic acid (VIA), histology and cryotherapy in low-resource settings. METHODS: Women having limited access to health-care facilities were screened by trained doctors using VIA. If the test was positive, biopsies were taken and when eligible, women were directly treated with cryotherapy. Follow-up was performed with VIA and cytology after 6 months. When cervical cancer was suspected or diagnosed, women were referred. The positivity rate, positive predictive value (PPV) and approximate specificity of the VIA test were calculated. The detection rate for cervical lesions was given. RESULTS: Screening results were completed in 22 040 women, of whom 92.7% had never been screened. Visual inspection with acetic acid was positive in 4.4%. The PPV of VIA to detect CIN I or greater and CIN II or greater was 58.7% and 29.7%, respectively. The approximate specificity was 98.1%, and the detection rate for CIN I or greater was 2.6%. CONCLUSION: The single-visit approach cervical cancer screening performed well, showing See and Treat is a promising way to reduce cervical cancer in Indonesia
PREVALENCE AND RISK FACTORS THAT AFFECT VIA RESULT IN JAKARTA FROM 2007-2011
Cervix cance
PREVALENCE AND RISK FACTORS THAT AFFECT VIA RESULT IN JAKARTA FROM 2007-2011
Cervix cance
Cytomorphological Analysis of Uterine Cervical Pap Smears in Relation to Human Papillomavirus Infection in Indonesian Women
TI1B - Ovariumpathologi
The Impact of Tick Size Reduction on Liquidity and Order Strategy: Evidence from the Jakarta Stock Exchange (JSX)
Single-visit approach of cervical cancer screening: See and Treat in Indonesia
BACKGROUND: We performed a cross-sectional study in Indonesia to evaluate the performance of a single-visit approach of cervical cancer screening, using visual inspection with acetic acid (VIA), histology and cryotherapy in low-resource settings. METHODS: Women having limited access to health-care facilities were screened by trained doctors using VIA. If the test was positive, biopsies were taken and when eligible, women were directly treated with cryotherapy. Follow-up was performed with VIA and cytology after 6 months. When cervical cancer was suspected or diagnosed, women were referred. The positivity rate, positive predictive value (PPV) and approximate specificity of the VIA test were calculated. The detection rate for cervical lesions was given. RESULTS: Screening results were completed in 22 040 women, of whom 92.7% had never been screened. Visual inspection with acetic acid was positive in 4.4%. The PPV of VIA to detect CIN I or greater and CIN II or greater was 58.7% and 29.7%, respectively. The approximate specificity was 98.1%, and the detection rate for CIN I or greater was 2.6%. CONCLUSION: The single-visit approach cervical cancer screening performed well, showing See and Treat is a promising way to reduce cervical cancer in Indonesia