In formation of dialectic differences in gagauz language on historical-ethnic factors

Gagauzs are an Orthodox Christian Turkic group. They live in countries such as Bulgaria, Greece, Moldova and Ukraine. Gagauz people living in Moldova can receive education in Gagauz language, because they have certain rights. The written language of Moldovan Gagauz is based on the Komrat-Çadır Lunga dialect. There is also the Valkaneş dialect, which is accepted as the southern mouth. The Comrat-Çadır Lunga dialect which is the central dialect and the Valkaneş dialect are actually based on the dialect differences in Bulgaria, where the Gagauz people lived for a while. In our study, the factors behind these dialect differences in the historical plan will be examined

Assessment of senior dental students and dental residents in matters of antimicrobial chemotherapy

This article highlights the results of the study designed to assess knowledge of senior dental students of medical schools and dental residents on the main issues of antibiotic therapy and the empirical use of antimicrobials for treatment of respiratory disorde

Phenol alkylation by ?-olefins on purpose to receive raw materials for production of multipurpose alkylphenol additives to oils

The article describes mechanisms of phenol alkylation by ?-olefins and some modern and the most effective catalysts which are used for phenol alkylation on purpose to receive raw materials for production of multipurpose alkylphenol additives to oil

Effect of antagonist mineralocorticoid receptors Eplerenon on the dynamics of QT interval dispersion in patients with acute elderly aged

Currently, there is an increase in the frequency of cardiovascular diseases, including acute coronary syndrome (ACS), while in the Russian Federation due to ACS there is a high mortality rate from sudden cardiac death (SCD). The aim of the work is a comparative analysis of the effect of mineralocorticoid receptor antagonists (MRA) of eplerenone on the predictors of SCD development in patients with ST elevation myocardial infarction (STEMI) with a moderately abnormal ejection fraction(EF) of the left ventricle (LV) in the early stages of the diseas

Biological activity of mesenchymal stem cells secretome as a basis for cell-free therapeutic approach

Mesenchymal stem (stromal) cells (MSCs) are self-renewing, cultured adult stem cells which secrete a complex set of multiple soluble biologically active molecules. Different population of MSCs can secret different factors which could have anti-inflammatory, anti-apoptotic, anti-fibrotic activities, a neuroprotective effect. The paracrine activity of conditioned medium obtained when cultivating MSCs, due to a plethora of bioactive factors, was assumed to have the most prominent cell-free therapeutic impact and can serve as a better option in the field of regenerative medicine in futur

Betahistine: targeting on vascular wall aging

Betahistine are routine drug in neurological practice, which is used to correct vertigo. The clinical efficacy of this drug can be caused not only by neuro-, but also by endotheliotropic action. In this review, the main information on the potential mechanisms for the implementation of vasoprotection, including metabolic, NO-ergic, anti-inflammatory and other components of the action are discusse

Expression of RUNX2 and osterix in rat mesenchymal stem cells during culturing in osteogenic-conditioned medium

We studied the expression of transcription factors RUNX2 and Osterix after addition of a concentrate of osteogenic-conditioned medium to the culture medium for osteogenic differentiation of mesenchymal stem cells (MSC

The role of the gut microbiota in the development of type 1 diabetes mellitus

At the beginning of the XXI century, with the advent of technical capabilities and new methods of genes sequencing, the attention of researchers to the study of the human metagenome has significantly increased. The interaction between changes in the qualitative and quantitative composition of the gut microbiota (GM) and various diseases is being actively studied, a search for specific metabolites and genes of microorganisms that may be associated with the development, in particular, of immune-mediated diseases is underway. In recent years, a lot of new data have been published on the possible contribution of gut flora dysbiosis to the development of Type 1 Diabetes Mellitus (T1DM), while the first assumptions were put forward as far back as 1970s. The search for pathogenetic mechanisms of GM influence on the development and progression of T1DM is becoming an increasingly relevant objective, since in recent years the incidence of T1DM is rapidly increasing, which is a serious health problem throughout the world.This review discusses the current ideas about the role of GM in the immunopathogenesis of T1DM, new data on the near-term prospects in the study of the human macrogenome, current ideas about the role of GM in the immunopathogenesis of T1DM, and the possibility of applying this knowledge by the practitioner

Comparative study of the pharmacological effects of Venarus Plus, Venarus, and Detralex on L-NAME-induced endothelial dysfunction, venous tone and platelet aggregation

In the present study we compared the pharmacological activity of Venarus Plus, Venarus and Detralex 1000 mg on the reversion of endothelial dysfunction (ED), and on the effect on venous tone, vascular permeability, and platelet aggregation. We used 150 Wistar male rats, weighing 180-220 g, and 80 adult albino rabbits weighing 2800 - 3200