Conceptions of Power and Role of Religion in Community Organising

Community organising, an approach aiming at building local leadership and empowering local communities, has become increasingly popular in the last few decades because of the crisis of more traditional practises of civil society building and political action. In this paper, the authors first describe the main tenets of this approach, formalised between the 1930s and the 1940s in Chicago by Saul Alinsky, and its history and evolution to the present day. The following paragraphs describe the role played by religious values and religious communities, often representing key institutions in rundown social and urban contexts, in this approach. In the last paragraph, the authors finally discuss the conception of power implied in the version of community organising proposed by the Industrial Areas Foundation (an organisation created by Alinsky) and its affiliates, and the role of religion in it. With this work, the authors argue that the relational and bottom-up idea of power proposed by the IAF and its affiliates, although often focused on the development of a local power base able to place political pressure on the authorities from below and even economic boycott campaigns, has increasingly also relied on soft power after Alinsky’s death, especially because of the development of the ‘relational’ side of community organising, a process where the involvement of religious congregations (with the weight of their moral authority) has played a major role

Knock-Down of Cathepsin D Affects the Retinal Pigment Epithelium, Impairs Swim-Bladder Ontogenesis and Causes Premature Death in Zebrafish

The lysosomal aspartic protease Cathepsin D (CD) is ubiquitously expressed in eukaryotic organisms. CD activity is essential to accomplish the acid-dependent extensive or partial proteolysis of protein substrates within endosomal and lysosomal compartments therein delivered via endocytosis, phagocytosis or autophagocytosis. CD may also act at physiological pH on small-size substrates in the cytosol and in the extracellular milieu. Mouse and fruit fly CD knock-out models have highlighted the multi-pathophysiological roles of CD in tissue homeostasis and organ development. Here we report the first phenotypic description of the lack of CD expression during zebrafish (Danio rerio) development obtained by morpholino-mediated knock-down of CD mRNA. Since the un-fertilized eggs were shown to be supplied with maternal CD mRNA, only a morpholino targeting a sequence containing the starting ATG codon was effective. The main phenotypic alterations produced by CD knock-down in zebrafish were: 1. abnormal development of the eye and of retinal pigment epithelium; 2. absence of the swim-bladder; 3. skin hyper-pigmentation; 4. reduced growth and premature death. Rescue experiments confirmed the involvement of CD in the developmental processes leading to these phenotypic alterations. Our findings add to the list of CD functions in organ development and patho-physiology in vertebrates