13 research outputs found
Adverse outcomes after colposcopy
Abstract Background Colposcopy is an essential part of the National Health Service Cervical Screening Programme (NHSCSP). It is used for both diagnosis and treatment of pre-cancerous cells of the cervix. Despite colposcopy being a commonly performed and relatively invasive procedure, very little research has explored the potential long-term impacts of colposcopic examination upon patient quality of life. The aim of this study is to investigate and quantify any potential reduction in women's quality of life following a colposcopy procedure. More specifically, the degree of female sexual dysfunction and the excess risk of adverse events in those undergoing colposcopy will be explored. If such risks are identified, these can be communicated to women before undergoing colposcopy. It will also assist in identifying whether there are particular sub-groups at greater risk and if so, this may lead to a re-evaluation of current recommendations concerning colposcopically directed treatments. Methods/design Cohort study using postal surveys to assess sexual function and quality of life in women who have attended for colposcopy (cases), compared with those who have not attended colposcopy (controls). The prevalence and excess risk of female sexual dysfunction will be determined. Logistic regression will identify the predictors of adverse outcomes. Discussion There are more than 400,000 colposcopy appointments each year in England, of which 134,000 are new referrals. There is some evidence that there may be long-term implications for women treated under colposcopy with respect to adverse obstetric outcomes, persisting anxiety, increased rates of sexual dysfunction and reduced quality of life. Reliably establishing whether such adverse outcomes exist and the excess risk of adverse events will facilitate informed decision-making and patient choice.</p
Fascinating facets of function and structure of amylolytic enzymes of glycoside hydrolase family 13
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Two separate dose-dependent effects of paroxetine: mydriasis and inhibition of tramadolâs O-demethylation via CYP2D6
Misclassification of patients relative to the reference interval.
<p>Dividing the patients in three subgroups based on the reference interval produces âBelowâ, âRef. intervalâ and âAboveâ. The table indicates the number of patients in each subgroup. The graph shows the same numbers in % for the subgroups âBelowâ and âAboveâ. The values in the âMisclassificationâ box are the number of patients misclassified at 2â3pm relative to 7â8am.</p
Total impact of resting time and diurnal variation on the biochemical compounds.
<p>The figure shows the change in mean value (in %) relative to the mean under the reference conditions (7â9am, resting time 15â30 minutes) for the four components A) albumin, B) thyrotropin, C) calcium and D) sodium. The shadowed background field indicates the limits for the MAB (1/3ĂSD<sub>pop</sub>). The values above the columns are the number of patients in each interval.</p