Nonlinear Rescaling of Control Laws with Application to Stabilization in the Presence of Magnitude Saturation

Motivated by some recent results on the stabilization of homogeneous systems, we present a gain-scheduling approach for the stabilization of non-linear systems. Given a one-parameter family of stabilizing feedbacks and associated Lyapunov functions, we show how the parameter can be rescaled as a function of the state to give a new stabilizing controller. In the case of homogeneous systems, we obtain generalizations of some existing results. We show that this approach can also be applied to nonhomogeneous systems. In particular, the main application considered in this paper is to the problem of stabilization with magnitude limitations. For this problem, we develop a design method for single-input controllable systems with eigenvalues in the left closed plane

Life cycle studies of the hexose transporter of Plasmodium species and genetic validation of their essentiality

A Plasmodium falciparum hexose transporter (PfHT) has previously been shown to be a facilitative glucose and fructose transporter. Its expression in Xenopus laevis oocytes and the use of a glucose analogue inhibitor permitted chemical validation of PfHT as a novel drug target. Following recent re-annotations of the P. falciparum genome, other putative sugar transporters have been identified. To investigate further if PfHT is the key supplier of hexose to P. falciparum and to extend studies to different stages of Plasmodium spp., we functionally analysed the hexose transporters of both the human parasite P. falciparum and the rodent parasite Plasmodium berghei using gene targeting strategies. We show here the essential function of pfht for the erythrocytic parasite growth as it was not possible to knockout pfht unless the gene was complemented by an episomal construct. Also, we show that parasites are rescued from the toxic effect of a glucose analogue inhibitor when pfht is overexpressed in these transfectants. We found that the rodent malaria parasite orthologue, P. berghei hexose transporter (PbHT) gene, was similarly refractory to knockout attempts. However, using a single cross-over transfection strategy, we generated transgenic P. berghei parasites expressing a PbHT–GFP fusion protein suggesting that locus is amenable for gene targeting. Analysis of pbht-gfp transgenic parasites showed that PbHT is constitutively expressed through all the stages in the mosquito host in addition to asexual stages. These results provide genetic support for prioritizing PfHT as a target for novel antimalarials that can inhibit glucose uptake and kill parasites, as well as unveiling the expression of this hexose transporter in mosquito stages of the parasite, where it is also likely to be critical for survival

Surfaces containing a family of plane curves not forming a fibration

We complete the classification of smooth surfaces swept out by a 1-dimensional family of plane curves that do not form a fibration. As a consequence, we characterize manifolds swept out by a 1-dimensional family of hypersurfaces that do not form a fibration.Comment: Author's post-print, final version published online in Collect. Mat

Measurement of the Higgs mass via the channel : e+e- -> ZH -> e+e- + X

In this communication, the mass declined for the decay channel, e+e- -> ZH -> e+e- + X, as measured by the ILD detector was studied. The Higgs mass is assumed to be 120 GeV and the center of mass energy is 250 GeV. For an integrated luminosity of 250 fb-1, the accuracy of the reconstruction and the good knowledge of the initial state allow for the measurement of the Higgs boson mass with a precision of about 100 MeV.Comment: 7 pages, 14 figures, LCWS/ILC 2010 (International Linear Collider Workshop 2010 LCWS10 and ILC10

Heat transfer during film condensation of potassium vapor on a horizontal plate

The object of the investigation is to analyze the following two features of heat transfer during condensation of potassium vapor: a. Heat transfer during film condensation of a pure saturated potassium vapor on a horizontal surface. b. Heat transfer during film condensation of potassium vapor in the presence of a small quantity of non-condensable gas. Until now, the discrepancy between theory and experiment concerning the condesnation of pure liquid-metal vapors has been explained by a thermal resistance at the liquid-vapor interface. This interfacial resistance was analyzed by means of the kinetic theory, and the results depended on the use of a condensation (or accommodation) coefficient. This coefficient was found to decrease in value at higher pressures. This work presents a more refined analysis of the interfacial temperature distribution, including the effect of subcooling in the vapor in the region of the liquid-vapor interface. Furthermore, a theory predicting the temperature drop in the condensate film on a horizontal plate is presented. Experiments were performed to verify the theory. In addition, data from previous investigators were analyzed. Experiments with non-condensable gases in the saturated vapor were made using the horizontal plate facing upward. These results supported Kroger's (19) theory.Sponsored by National Science Foundatio

Continuum of care for persons with common mental health disorders in Nunavik: a descriptive study.

BACKGROUND: Changing Directions, Changing Lives, the Mental Health Strategy for Canada, prioritizes the development of coordinated continuums of care in mental health that will bridge the gap in services for Inuit populations. OBJECTIVE: In order to target ways of improving the services provided in these contexts to individuals in Nunavik with depression or anxiety disorders, this research examines delays and disruptions in the continuum of care and clinical, individual and organizational characteristics possibly associated with their occurrences. DESIGN: A total of 155 episodes of care involving a common mental disorder (CMD), incident or recurring, were documented using the clinical records of 79 frontline health and social services (FHSSs) users, aged 14 years and older, living in a community in Nunavik. Each episode of care was divided into 7 stages: (a) detection; (b) assessment; (c) intervention; (d) planning the first follow-up visit; (e) implementation of the first follow-up visit; (f) planning a second follow-up visit; (g) implementation of the second follow-up visit. Sequential analysis of these stages established delays for each one and helped identify when breaks occurred in the continuum of care. Logistic and linear regression analysis determined whether clinical, individual or organizational characteristics influenced the breaks and delays. RESULTS: More than half (62%) the episodes of care were interrupted before the second follow-up. These breaks mostly occurred when planning and completing the first follow-up visit. Episodes of care were more likely to end early when they involved anxiety disorders or symptoms, limited FHSS teams and individuals over 21 years of age. The median delay for the first follow-up visit (30 days) exceeded guideline recommendations significantly (1-2 weeks). CONCLUSION: Clinical primary care approaches for CMDs in Nunavik are currently more reactive than preventive. This suggests that recovery services for those affected are suboptimal

Quality assessment of primary care for common mental disorders in isolated communities: Taking advantage of health records.

INTRODUCTION: This article is part of a research study on the organization of primary health care (PHC) for mental health in two of Quebec's remote regions. It introduces a methodological approach based on information found in health records, for assessing the quality of PHC offered to people suffering from depression or anxiety disorders. METHODS: Quality indicators were identified from evidence and case studies were reconstructed using data collected in health records over a 2-year observation period. Data collection was developed using a three-step iterative process: (1) feasibility analysis, (2) development of a data collection tool, and (3) application of the data collection method. The adaptation of quality-of-care indicators to remote regions was appraised according to their relevance, measurability and construct validity in this context. RESULTS: As a result of this process, 18 quality indicators were shown to be relevant, measurable and valid for establishing a critical quality appraisal of four recommended dimensions of PHC clinical processes: recognition, assessment, treatment and follow-up. CONCLUSIONS: There is not only an interest in the use of health records to assess the quality of PHC for mental health in remote regions but also a scientific value for the rigorous and meticulous methodological approach developed in this study. From the perspective of stakeholders in the PHC system of care in remote areas, quality indicators are credible and provide potential for transferability to other contexts. This study brings information that has the potential to identify gaps in and implement solutions adapted to the context

Donor Electron Wave Functions for Phosphorus in Silicon: Beyond Effective Mass Theory

We calculate the electronic wave-function for a phosphorus donor in silicon by numerical diagonalisation of the donor Hamiltonian in the basis of the pure crystal Bloch functions. The Hamiltonian is calculated at discrete points localised around the conduction band minima in the reciprocal lattice space. Such a technique goes beyond the approximations inherent in the effective-mass theory, and can be modified to include the effects of altered donor impurity potentials, externally applied electro-static potentials, as well as the effects of lattice strain. Modification of the donor impurity potential allows the experimentally known low-lying energy spectrum to be reproduced with good agreement, as well as the calculation of the donor wavefunction, which can then be used to calculate parameters important to quantum computing applications.Comment: 10 pages, 5 figure

What controls the large-scale magnetic fields of M dwarfs?

Observations of active M dwarfs show a broad variety of large-scale magnetic fields encompassing dipole-dominated and multipolar geometries. We detail the analogy between some anelastic dynamo simulations and spectropolarimetric observations of 23 M stars. In numerical models, the relative contribution of inertia and Coriolis force in the global force balance -estimated by the so-called local Rossby number- is known to have a strong impact on the magnetic field geometry. We discuss the relevance of this parameter in setting the large-scale magnetic field of M dwarfs.Comment: 4 pages, 3 figures, conference proceeding, IAUS 302 'Magnetic Fields Throughout the Stellar Evolution', (26-30 Aug 2013, Biarritz, France

A homomorphism between link and XXZ modules over the periodic Temperley-Lieb algebra

We study finite loop models on a lattice wrapped around a cylinder. A section of the cylinder has N sites. We use a family of link modules over the periodic Temperley-Lieb algebra EPTL_N(\beta, \alpha) introduced by Martin and Saleur, and Graham and Lehrer. These are labeled by the numbers of sites N and of defects d, and extend the standard modules of the original Temperley-Lieb algebra. Beside the defining parameters \beta=u^2+u^{-2} with u=e^{i\lambda/2} (weight of contractible loops) and \alpha (weight of non-contractible loops), this family also depends on a twist parameter v that keeps track of how the defects wind around the cylinder. The transfer matrix T_N(\lambda, \nu) depends on the anisotropy \nu and the spectral parameter \lambda that fixes the model. (The thermodynamic limit of T_N is believed to describe a conformal field theory of central charge c=1-6\lambda^2/(\pi(\lambda-\pi)).) The family of periodic XXZ Hamiltonians is extended to depend on this new parameter v and the relationship between this family and the loop models is established. The Gram determinant for the natural bilinear form on these link modules is shown to factorize in terms of an intertwiner i_N^d between these link representations and the eigenspaces of S^z of the XXZ models. This map is shown to be an isomorphism for generic values of u and v and the critical curves in the plane of these parameters for which i_N^d fails to be an isomorphism are given.Comment: Replacement of "The Gram matrix as a connection between periodic loop models and XXZ Hamiltonians", 31 page