1,639 research outputs found
An Investigation of the Reaction of Bromopicrin with Liquid Ammonia
The purpose of this research was to study the reaction between bromopicrin, also referred to as nitro-bromoform or tribromomonitromethane, with liquid ammonia. It seems surprising, but very little has been done on the reaction between these halogen nitro derivatives of methane and liquid ammonia
Mechanism for nonequilibrium symmetry breaking and pattern formation in magnetic films
Magnetic thin films exhibit a strong variation in properties depending on
their degree of disorder. Recent coherent x-ray speckle experiments on magnetic
films have measured the loss of correlation between configurations at opposite
fields and at the same field, upon repeated field cycling. We perform finite
temperature numerical simulations on these systems that provide a comprehensive
explanation for the experimental results. The simulations demonstrate, in
accordance with experiments, that the memory of configurations increases with
film disorder. We find that non-trivial microscopic differences exist between
the zero field spin configuration obtained by starting from a large positive
field and the zero field configuration starting at a large negative field. This
seemingly paradoxical beahvior is due to the nature of the vector spin dynamics
and is also seen in the experiments. For low disorder, there is an instability
which causes the spontaneous growth of line-like domains at a critical field,
also in accord with experiments. It is this unstable growth, which is highly
sensitive to thermal noise, that is responsible for the small correlation
between patterns under repeated cycling. The domain patterns, hysteresis loops,
and memory properties of our simulated systems match remarkably well with the
real experimental systems.Comment: 12 pages, 10 figures Added comparison of results with
cond-mat/0412461 and some more discussio
Adjusting the frequency of mammography screening on the basis of genetic risk: Attitudes among women in the UK.
Purpose
To explore public attitudes towards modifying frequency of mammography screening based on genetic risk.
Methods
Home-based interviews were carried out with a population-based sample of 942 women aged 18ā74 years in the UK. Demographic characteristics and perceived breast cancer (BC) risk were examined as predictors of support for risk-stratified BC screening and of the acceptability of raised or lowered screening frequency based on genetic risk, using multivariate logistic regression.
Results
Over two-thirds of respondents (65.8%) supported the idea of varying screening frequency on the basis of genetic risk. The majority (85.4%) were willing to have more frequent breast screening if they were found to be at higher risk, but fewer (58.8%) were willing to have less frequent screening if at lower risk (t (956) = 15.6, p < 0.001). Ethnic minority status was associated with less acceptability of more frequent screening (OR = 0.40, 95% CI = 0.21ā0.74), but there were no other significant demographic correlates. Higher perceived risk of BC was associated with greater acceptability of more frequent screening (OR = 1.71, 95%CI = 1.27ā2.30).
Conclusion
Women were positive about adjusting the frequency of mammography screening in line with personal genetic risk, but it will be important to develop effective communication materials to minimise resistance to reducing screening frequency for those at lower genetic risk
Dependence of X-Ray Burst Models on Nuclear Reaction Rates
X-ray bursts are thermonuclear flashes on the surface of accreting neutron
stars and reliable burst models are needed to interpret observations in terms
of properties of the neutron star and the binary system. We investigate the
dependence of X-ray burst models on uncertainties in (p,),
(,), and (,p) nuclear reaction rates using fully
self-consistent burst models that account for the feedbacks between changes in
nuclear energy generation and changes in astrophysical conditions. A two-step
approach first identified sensitive nuclear reaction rates in a single-zone
model with ignition conditions chosen to match calculations with a
state-of-the-art 1D multi-zone model based on the {\Kepler} stellar evolution
code. All relevant reaction rates on neutron deficient isotopes up to mass 106
were individually varied by a factor of 100 up and down. Calculations of the 84
highest impact reaction rate changes were then repeated in the 1D multi-zone
model. We find a number of uncertain reaction rates that affect predictions of
light curves and burst ashes significantly. The results provide insights into
the nuclear processes that shape X-ray burst observables and guidance for
future nuclear physics work to reduce nuclear uncertainties in X-ray burst
models.Comment: 24 pages, 13 figures, 4 tables, submitte
Ultrasound attenuation and a P-B-T phase diagram of superfluid 3He in 98% aerogel
Longitudinal sound attenuation measurements in superfluid 3He in 98% aerogel
were conducted at pressures between 14 and 33 bar and in magnetic fields up to
4.44 kG. The temperature dependence of the ultrasound attenuation in the A-like
phase was determined for the entire superfluid region exploiting the field
induced meta-stable A-like phase at the highest field. In the lower field, the
A-B transition in aerogel was identified by a smooth jump in attenuation on
both cooling and warming. Based on the transitions observed on warming, a phase
diagram as a function of pressure (P), temperature (T) and magnetic field (B)
is constructed. We find that the A-B phase boundary in aerogel recedes in a
drastically different manner than in bulk in response to an increasing magnetic
field. The implications of the observed phase diagram are discussed.Comment: 9 pages, 13 figures, accepted to PR
ESR Study of (C_5H_{12}N)_2CuBr_4
ESR studies at 9.27, 95.4, and 289.7 GHz have been performed on
(CHN)CuBr down to 3.7 K. The 9.27 GHz data were acquired
with a single crystal and do not indicate the presence of any structural
transitions. The high frequency data were collected with a polycrystalline
sample and resolved two absorbances, consistent with two crystallographic
orientations of the magnetic sites and with earlier ESR studies performed at
300 K. Below T, our data confirm the presence of a spin singlet
ground state.Comment: 2 pages, 4 figs., submitted 23rd International Conference on Low
Temperature Physics (LT-23), Aug. 200
Induction and inhibition of Drosophila X chromosome gene expression are both impeded by the dosage compensation complex
Sex chromosomes frequently differ from the autosomes in the frequencies of genes with sexually dimorphic or tissue-specific expression. Multiple hypotheses have been put forth to explain the unique gene content of the X chromosome, including selection against male-beneficial X-linked alleles, expression limits imposed by the haploid dosage of the X in males, and interference by the dosage compensation complex on expression in males. Here, we investigate these hypotheses by examining differential gene expression in Drosophila melanogaster following several treatments that have widespread transcriptomic effects: bacterial infection, viral infection, and abiotic stress. We found that genes that are induced (upregulated) by these biotic and abiotic treatments are frequently under-represented on the X chromosome, but so are those that are repressed (downregulated) following treatment. We further show that whether a gene is bound by the dosage compensation complex in males can largely explain the paucity of both up- and downregulated genes on the X chromosome. Specifically, genes that are bound by the dosage compensation complex, or close to a dosage compensation complex high-affinity site, are unlikely to be up- or downregulated after treatment. This relationship, however, could partially be explained by a correlation between differential expression and breadth of expression across tissues. Nonetheless, our results suggest that dosage compensation complex binding, or the associated chromatin modifications, inhibit both up- and downregulation of X chromosome gene expression within specific contexts, including tissue-specific expression. We propose multiple possible mechanisms of action for the effect, including a role of Males absent on the first, a component of the dosage compensation complex, as a dampener of gene expression variance in both males and females. This effect could explain why the Drosophila X chromosome is depauperate in genes with tissue-specific or induced expression, while the mammalian X has an excess of genes with tissue-specific expression
S-Adenosyl homocysteine and DNA ends stimulate promiscuous nuclease activities in the Type III restriction endonuclease EcoPI
In the absence of the methyl donor S-adenosyl methionine and under certain permissive reaction conditions, EcoPI shows non-specific endonuclease activity. We show here that the cofactor analogue S-adenosyl homocysteine promotes this promiscuous DNA cleavage. Additionally, an extensive exonuclease-like processing of the DNA is also observed that can even result in digestion of non-specific DNA in trans. We suggest a model for how DNA communication events initiating from non-specific sites, and in particular free DNA ends, could produce the observed cleavage patterns
Size dependence of the photoinduced magnetism and long-range ordering in Prussian blue analog nanoparticles of rubidium cobalt hexacyanoferrate
Nanoparticles of rubidium cobalt hexacyanoferrate
(RbCo[Fe(CN)]HO) were synthesized using different
concentrations of the polyvinylpyrrolidone (PVP) to produce four different
batches of particles with characteristic diameters ranging from 3 to 13 nm.
Upon illumination with white light at 5 K, the magnetization of these particles
increases. The long-range ferrimagnetic ordering temperatures and the coercive
fields evolve with nanoparticle size. At 2 K, particles with diameters less
than approximately 10 nm provide a Curie-like magnetic signal.Comment: 10 pages, 6 figures in text, expanded text and dat
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