Adverse events following influenza immunization reported by healthcare personnel using active surveillance based on text messages

Studies have demonstrated that healthcare personnel (HCP) have concerns about the potential side effects of trivalent inactivate influenza vaccine (IIV3).1-3 A recent metaanalysis of reasons HCP refuse IIV3 indicates the strongest predictors of vaccine acceptance are belief that the vaccine is safe and belief the vaccine does not cause the disease it is meant to prevent.

Slowdown and splitting of gap solitons in apodized Bragg gratings

We study the motion of gap solitons in two models of apodized nonlinear fiber Bragg gratings (BGs), with the local reflectivity (LR) varying along the fiber. A single step of LR, and a periodic array of alternating steps with opposite signs (a "Bragg superstructure") are considered. A challenging possibility is to slow down and eventually halt the soliton by passing it through the step of increasing reflectivity, thus capturing a pulse of standing light. First, we develop an analytical approach, assuming adiabatic evolution of the soliton, and making use of the energy conservation and balance equation for the momentum. Comparison with simulations shows that the analytical approximation is quite accurate (unless the inhomogeneity is too steep): the soliton is either transmitted across the step or bounces back. If the step is narrow, systematic simulations demontrate that the soliton splits into transmitted and reflected pulses (splitting of a BG soliton which hits a chirped grating was observed in experiments). Moving through the periodic "superstructure", the soliton accummulates distortion and suffers radiation loss if the structure is composed of narrow steps. The soliton moves without any loss or irreversible deformation through the array of sufficiently broad steps.Comment: to appear in a special issue on Wave-Optical Engineering, Journal of Modern Optic

Inter- and Intra-Chain Attractions in Solutions of Flexible Polyelectrolytes at Nonzero Concentration

Constant temperature molecular dynamics simulations were used to study solutions of flexible polyelectrolyte chains at nonzero concentrations with explicit counterions and unscreened coulombic interactions. Counterion condensation, measured via the self-diffusion coefficient of the counterions, is found to increase with polymer concentration, but contrary to the prediction of Manning theory, the renormalized charge fraction on the chains decreases with increasing Bjerrum length without showing any saturation. Scaling analysis of the radius of gyration shows that the chains are extended at low polymer concentrations and small Bjerrum lengths, while at sufficiently large Bjerrum lengths, the chains shrink to produce compact structures with exponents smaller than a gaussian chain, suggesting the presence of attractive intrachain interactions. A careful study of the radial distribution function of the center-of-mass of the polyelectrolyte chains shows clear evidence that effective interchain attractive interactions also exist in solutions of flexible polyelectrolytes, similar to what has been found for rodlike polyelectrolytes. Our results suggest that the broad maximum observed in scattering experiments is due to clustering of chains.Comment: 12 pages, REVTeX, 15 eps figure

Human P450 CYP17A1: Control of Substrate Preference by Asparagine 202

CYP17A1 is a key steroidogenic enzyme known to conduct several distinct chemical transformations on multiple substrates. In its hydroxylase activity, this enzyme adds a hydroxyl group at the 17α position of both pregnenolone and progesterone at approximately equal rates. However, the subsequent 17,20 carbon–carbon scission reaction displays variable substrate specificity in the numerous CYP17A1 isozymes operating in vertebrates, manifesting as different Kd and kcat values when presented with 17α-hydroxypregnenlone (OHPREG) versus 17α-hydroxyprogesterone (OHPROG). Here we show that the identity of the residue at position 202 in human CYP17A1, thought to form a hydrogen bond with the A-ring alcohol substituent on the pregnene- nucleus, is a key driver of this enzyme’s native preference for OHPREG. Replacement of asparagine 202 with serine completely reverses the preference of CYP17A1, more than doubling the rate of turnover of the OHPROG to androstenedione reaction and substantially decreasing the rate of formation of dehydroepiandrosterone from OHPREG. In a series of resonance Raman experiments, it was observed that, in contrast with the case for the wild-type protein, in the mutant the 17α alcohol of OHPROG tends to form a H-bond with the proximal rather than terminal oxygen of the oxy–ferrous complex. When OHPREG was a substrate, the mutant enzyme was found to have a H-bonding interaction with the proximal oxygen that is substantially weaker than that of the wild type. These results demonstrate that a single-point mutation in the active site pocket of CYP17A1, even when far from the heme, has profound effects on steroidogenic selectivity in androgen biosynthesis

Relativistic Compact Objects in Isotropic Coordinates

We present a matrix method for obtaining new classes of exact solutions for Einstein's equations representing static perfect fluid spheres. By means of a matrix transformation, we reduce Einstein's equations to two independent Riccati type differential equations for which three classes of solutions are obtained. One class of the solutions corresponding to the linear barotropic type fluid with an equation of state $p=\gamma \rho$ is discussed in detail.Comment: 9 pages, no figures, accepted for publication in Pramana-Journal of Physic

Renormalization Group Approach to Causal Viscous Cosmological Models

The renormalization group method is applied to the study of homogeneous and flat Friedmann-Robertson-Walker type Universes, filled with a causal bulk viscous cosmological fluid. The starting point of the study is the consideration of the scaling properties of the gravitational field equations, of the causal evolution equation of the bulk viscous pressure and of the equations of state. The requirement of scale invariance imposes strong constraints on the temporal evolution of the bulk viscosity coefficient, temperature and relaxation time, thus leading to the possibility of obtaining the bulk viscosity coefficient-energy density dependence. For a cosmological model with bulk viscosity coefficient proportional to the Hubble parameter, we perform the analysis of the renormalization group flow around the scale invariant fixed point, therefore obtaining the long time behavior of the scale factor.Comment: 19 pages. RevTeX4. Revised version. Accepted in Classical and Quantum Gravit

Sustainability of the Chinese Economic Expansion

China\u27s economy has developed in such a startling way that most people – economists or not – place, as starting from about 1978, and many are questioning whether or not it can last? At the same time, they are wondering about its effect on the United States, and the world at large, because China is such a big country. In this presentation, we will look at the question: Can the Chinese economic expansion be sustained? Personally, we believe that it is, in fact sustainable, not necessarily at the present speed, and cannot say confidently that it will, in fact, be sustained. However, we have been “bullish†on China ever since visiting the country in 1979 and have been tracking the course of forecasts about performance ever since. Now, we are on a bi-weekly schedule of producing and studying the statistical outcome in some detail

Viscous Bianchi type I universes in brane cosmology

We consider the dynamics of a viscous cosmological fluid in the generalized Randall-Sundrum model for an anisotropic, Bianchi type I brane. To describe the dissipative effects we use the Israel-Hiscock-Stewart full causal thermodynamic theory. By assuming that the matter on the brane obeys a linear barotropic equation of state, and the bulk viscous pressure has a power law dependence on the energy density, the general solution of the field equations can be obtained in an exact parametric form. The obtained solutions describe generally a non-inflationary brane world. In the large time limit the brane Universe isotropizes, ending in an isotropic and homogeneous state. The evolution of the temperature and of the comoving entropy of the Universe is also considered, and it is shown that due to the viscous dissipative processes a large amount of entropy is created in the early stages of evolution of the brane world.Comment: 13 pages, 5 figures, to appear in Class. Quantum Gra