Establishment of Bone Marrow Stroma from Patients at Pre and Post-Mobilization for Autologous Peripheral Blood Stem Cells Transplantation

Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USAUniversidade Federal de São Paulo, São Paulo, BrazilUniv State São Paulo, São Paulo, BrazilUniversidade Federal de São Paulo, São Paulo, BrazilWeb of Scienc

Motives for desiring children among individuals of different sexual-romantic orientations: a cross-sectional study.

PURPOSE Little is known about the reasoning behind the desire to have children in non-heterosexual individuals. This study compares the motives of different sexual-romantic orientations and their preferred ways of fulfilling this desire. METHODS This was a monocentric cross-sectional study. Subjects were recruited via social media, personal contacts and queer organisations in Switzerland. An anonymous questionnaire comprised general questions about the participant's background, a validated survey about the desire to have children and additional non-validated questions addressing the impact of sexual-romantic orientation on the desire to have children. The inclusion criteria were adults without children and a completed questionnaire. RESULTS Of 837 participants, 642 were included in the study. Four groups of sexual-romantic orientations consisted of more than 35 participants: bisexual-biromantic (n = 38), heterosexual-heteroromantic (n = 230), homosexual-homoromantic (n = 159) and pansexual-panromantic (n = 55). Subgroups with a positive wish for a child rated all motives in the same order and with minimal numeric difference. The most important aspect seemed to be emotional involvement. Non-heterosexual-heteroromantic showed concerns about adverse reactions regarding their wish for a child. All orientations hoped for a biological child. CONCLUSION Our findings about bi-, hetero-, homo- and pansexual people and their motives for a desire to have children agree with the existing literature about hetero, homo and bisexual. The impact of the fear of adverse reaction and discrimination has been discussed before and is supported by our data. We suggest better support before and during the realization of the wish for a child as well as support for non-traditional aspiring parents

An extended Menopause Rating Scale II: a retrospective data analysis.

OBJECTIVE This study aims to discuss a statistically reasonable inclusion of additional questions in the Menopause Rating Scale II (MRS II) for daily use in clinical practice. METHODS Retrospective data analysis was performed (cantonal ethics committee No. 2016-01179). The MRS II was extended with the parameters 'changes in weight', 'headaches', 'skin changes', 'changes in hair growth', 'hair loss', and whether therapy was desired. Data from 419 women seeking medical advice in our menopause center were collected between April 2009 and April 2017. Cronbach's alpha was used to measure internal consistency of the extended questionnaire. RESULTS For the conventional MRS II (N = 340 of 419, 81.1%), the internal consistency measured with Cronbach's alpha increased from 0.805 to 0.820 considering 'changes in weight' (N = 237, 56.6%), to 0.815 considering 'headaches' (N = 247, 58.9%), and to 0.815 considering 'skin changes' (N = 236, 56.3%) if these additional parameters were added separately. Cronbach's alpha increased from 0.805 to 0.835 (N = 224, 53.5%) if these parameters were added at once. Desire for therapy varied between 42.1% for 'changes in hair growth' (N = 38, 9.1%) and 60.6% for 'hair loss' (N = 33, 7.9%). CONCLUSION We suggest including the items 'changes in weight', 'headaches', and 'skin changes' in the MRS II as our results show even higher internal consistency with these symptoms and as the wish for therapy was high

Evaporator Frosting in Refrigerating Appliances: Fundamentals and Applications

Modern refrigerators are equipped with fan-supplied evaporators often tailor-made to mitigate the impacts of frost accretion, not only in terms of frost blocking, which depletes the cooling capacity and therefore the refrigerator coefficient of performance (COP), but also to allow optimal defrosting, thereby avoiding the undesired consequences of condensate retention and additional thermal loads. Evaporator design for frosting conditions can be done either empirically through trial-and-error approaches or using simulation models suitable to predict the distribution of the frost mass along the finned coil. Albeit the former is mandatory for robustness verification prior to product approval, it has been advocated that the latter speeds up the design process and reduces the costs of the engineering undertaking. Therefore, this article is aimed at summarizing the required foundations for the design of efficient evaporators and defrosting systems with minimized performance impacts due to frosting. The thermodynamics, and the heat and mass transfer principles involved in the frost nucleation, growth, and densification phenomena are presented. The thermophysical properties of frost, such as density and thermal conductivity, are discussed, and their relationship with refrigeration operating conditions are established. A first-principles model is presented to predict the growth of the frost layer on the evaporator surface as a function of geometric and operating conditions. The relation between the microscopic properties of frost and their macroscopic effects on the evaporator thermo-hydraulic performance is established and confirmed with experimental evidence. Furthermore, different defrost strategies are compared, and the concept of optimal defrost is formulated. Finally, the results are used to analyze the efficiency of the defrost operation based on the net cooling capacity of the refrigeration system for different duty cycles and evaporator geometries

Evidence for in-plane antiferromagnetic domains in ultrathin NiO films

none7D. SPANKE; V. SOLINUS; D. KNABBEN; F.U. HILLEBRECHT; F. CICCACCI; L. GREGORATTI; M. MARSID., Spanke; V., Solinus; D., Knabben; F. U., Hillebrecht; Ciccacci, Franco; L., Gregoratti; M., Mars