Reaction of 2-methoxy-1,3,2-dioxa-phosphorino[4,5-b]pyridin-4(4H)-one with hexafluoroacetone

The reaction of the di-O-trimethylsilyl derivative of 2-hydroxynicotinic acid with methyl phosphodichloridite afforded 2-methoxy-1,3,2- dioxaphosphorino[4,5-b]pyridin-4(4H )-one. The NMR spectrkscopic data suggest that the reaction of the latter with hexafluoroacetone produces unstable 2-methoxy-2,5-dioxo-4,4-bis(trifluoromethyl)-4,5-dihydro-1,3,2-dioxa- phosphepino[4,5-b]pyridine, which is readily transformed into 9-methyl-2,5-dioxo-4,4- bis(trifluoromethyl)-4,5-dihydro-1,3,2- dioxaphosphepino[4,5-b]pyrid-9-inium-2-oate. The structure of the hydrolysis product of the latter, viz., 1-methyl-3-(2-hydroxy-3,3,3-trifluoro-2- trifluoromethylpropanoyl)pyridin-2-one, was established by X-ray diffraction analysis. © 2004 Springer Science+Business Media, Inc

Tecnología para la formación temprana de resistencia al estrés en el sistema de prevención de la mala adaptación escolar de alumnos de primer grado

The relevance of the stated problem of the crisis of 6-7-year old’s is dictated by the recently growing tendency to bring back children to preschool institutions after a short period at school by parents who notice the child’s painful condition associated with school maladaptation. In this regard, many researchers and practicing educators recommend reviewing the start dates for children at school so that the child starts school at the age of seven. Other teachers notice a significant increase in the work load on primary schoolchildren connected to the introduction of the Federal State Educational Standard for Primary General Education and the corresponding forms of control and assessment activities. Thus, there was a need to develop new technologies to preserve the health of younger students and allow them to overcome the crisis of the onset of education. The purpose of this article is to describe the developed technology aimed at helping 6-7-year old to overcome the age crisis and prevent school maladaptation with the help of early formation of stress tolerance. The main method in the study is the design of a technology for early formation of stress tolerance and prediction of the results of its implementation in the experimental groups of 6-7-year-old children. The technology is based on the principles of continuity of the educational process between preschool educational organizations and schools. With the implementation of the developed technology the following results were achieved: increased motivation for success and higher somatic health level manifested in sport and creative activities. The above-mentioned results in their turn contributed to crisis prevention, school deprivation of first graders and comfortable overcoming of the crisis of 6-7 year olds. The materials of the article can be useful to organizers of sport and creative activities in preschool educational institutions, educators of preparatory groups, teachers, methodologists in preschool and primary education, as well as physical education teachers and primary school teachers. The materials of the article can be used in the system of advanced training of teachers of physical education and elementary school, as well as in the preparation for professional activities in preschool educational institutions and elementary schools of students of teacher training colleges and universities.La relevancia del problema declarado de la crisis de los niños de 6 a 7 años está dictada por la tendencia cada vez mayor de traer a los niños a las instituciones preescolares después de un corto período en la escuela por parte de los padres que notan la condición dolorosa del niño asociada con la mala adaptación escolar. En este sentido, muchos investigadores y educadores en ejercicio recomiendan revisar las fechas de inicio de los niños en la escuela para que el niño comience la escuela a la edad de siete años. Otros maestros notan un aumento significativo en la carga de trabajo de los escolares de primaria relacionados con la introducción del Estándar Educativo del Estado Federal para la Educación General Primaria y las formas correspondientes de actividades de control y evaluación. Por lo tanto, era necesario desarrollar nuevas tecnologías para preservar la salud de los estudiantes más jóvenes y permitirles superar la crisis del inicio de la educación. El propósito del artículo es describir la tecnología desarrollada destinada a ayudar a niños de 6 a 7 años a superar la crisis de la edad y prevenir la mala adaptación escolar con la ayuda de la formación temprana de tolerancia al estrés. El método principal en el estudio es el diseño de una tecnología para la formación temprana de tolerancia al estrés y la predicción de los resultados de su implementación en los grupos experimentales de niños de 6-7 años. La tecnología se basa en los principios de continuidad del proceso educativo entre las organizaciones educativas preescolares y las escuelas. Con la implementación de la tecnología desarrollada se lograron los siguientes resultados: mayor motivación para el éxito y un mayor nivel de salud somática manifestado en actividades deportivas y creativas. Los resultados mencionados a su vez contribuyeron a la prevención de crisis, la privación escolar de los alumnos de primer grado y la superación cómoda de la crisis de los niños de 6 a 7 años. Los materiales del artículo pueden ser útiles para los organizadores de actividades deportivas y creativas en instituciones educativas preescolares, educadores de grupos preparatorios, maestros, metodólogos en educación preescolar y primaria, así como maestros de educación física y maestros de primaria. Los materiales del artículo se pueden utilizar en el sistema de formación avanzada de docentes de educación física y primaria, así como en la preparación de actividades profesionales en instituciones educativas preescolares y escuelas primarias de estudiantes de escuelas de formación de docentes y universidades

Recherche écosanté en pratique : applications novatrices d’une approche écosystémique de la santé

Publié conjointement avec SpringerVersion anglaise disponible dans la Bibliothèque numérique du CRDI : Ecohealth research in practice : innovative applications of an ecosystem approach to healthVersion espagnole disponible dans la Bibliothèque numérique du CRDI : Investigación de ecosalud en la práctica : aplicaciones innovadoras de un enfoque ecosistémico para la saludPrès de vingt ans après la Conférence des Nations-Unies sur l’environnement et le développement (le Sommet de Rio), la nécessité d’atténuer la pauvreté et d’améliorer les conditions de vie grâce à un accès plus équitable aux ressources, à l’utilisation judicieuse de ces dernières et à des milieux ambiants plus sains est toujours aussi vive. Conscients que la santé humaine est intimement liée aux écosystèmes, les chercheurs tracent de nouvelles voies vers un avenir plus durable. Une approche écosystémique de la santé, alliant la recherche et la pratique dans des domaines aussi variés que la gestion de l’environnement, la santé publique, la biodiversité et le développement économique, se fonde sur la conviction que l’être humain fait partie intégrante de systèmes socioécologiques complexes. En présentant des études de cas menées dans diverses régions du monde, Ecohealth Research in Practice rend compte de pratiques novatrices en agriculture, gestion des ressources naturelles, renforcement des collectivités et prévention des maladies témoignant des plus récents progrès en ce qui concerne la recherche, ses applications et l’élaboration de politiques dans le domaine. Le livre montre les rouages de la recherche en écosanté et illustre comment elle a produit des changements qui ont amélioré de manière durable les conditions de vie des populations et les écosystèmes les soutenant

Reaction of 5-oxo-2-phenyl-4,4-bis(trifluoromethyl)-4,5-dihydro-1,3,2- benzodioxaphosphepine with chloral. the synthesis and spatial structure of 5-carbaphosphatrane containing a four-membered ring

Phosphorylation of 2-hydroxyphenyl 2,2,2-trifluoro-1-hydroxy-1- (trifluoromethyl)ethyl ketone with dichloro(phenyl)phosphine gave 5-oxo-2-phenyl-4,4-bis(trifluoromethyl)-4,5-di-hydro-1,3,2- benzodioxaphosphepine. Heating of the latter initiated an intramolecular interaction of the P atom with the carbonyl group. Hydrolysis of the intermediate product yielded 3-hydroxy-2-oxo-2-phenyl-3-[2,2,2-trifluoro-1- hydroxy-1-(trifluoromethyl)ethyl]-2,3-di-hydro-1,2λ5-benzo[d] oxaphosphole. The reaction was highly stereoselective (PRC S/PSCR). The reaction of the starting phosphepine with chloral proceeded highly stereoselectively (PRC SCS/PSCRCR) to give a 5-carbaphosphatrane derivative containing a four-membered ring, namely, 1-phenyl-3-trichloromethyl-10,10-bis(trifluoromethyl)-6,7-benzo-2,4,8, 9-tetraoxa-1λ5-phosphatricyclo[3.3.2.01, 5]decene. The trigonal bipyramid of the 5-carbaphosphatrane derivative is made up of the equatorial O atoms and the apical C atoms. © 2010 Springer Science+Business Media, Inc

Preparation and steric structure of 2-Alkoxy-2,5-dioxo-4,4- bis(trifluoromethyl)-7(8)-chloro-1,3,2λ5- benzodioxaphosphepins : EEffect of fluorinated fragments on the crystal packing

The reaction of hexafluoroacetone with 2-alkoxy-6(7)-chloro-1,3,2- benzodioxaphosphorin-4-ones yielded 7-and 8-chloro-substituted 2-alkoxy-2,5-dioxo-4,4-bis(trifluoromethyl)-1,3,2λ5- benzodioxaphosphepines. Their steric structure was studied by single-crystal X-ray diffraction. The effect of fluorinated substituents on the crystal packing of the benzophosphepines was demonstrated. Hydrolysis of these compounds gave the corresponding 4-and 5-chloro-substituted 2-(2-hydroxyphenyl)-2-oxo-1,1- bis(trifluoromethyl)-ethanols; the structure of 2-(2-hydroxy-5-chlorophenyl)-2- oxo-1,1-bis(trifluoromethyl)ethanol was also proved by single-crystal X-ray diffraction. © Pleiades Publishing, Inc., 2006

An unusual cascade reaction of 4,5-dihydro-4,4-bis(trifluoromethyl)-2-phenyl-6,7-(4-chlorobenzo)[e]-1,3,2-dioxaphosphepin-5-one with chloral

The reaction of 4,5-dihydro-4,4-bis(trifluoromethyl)-2-phenyl-6,7-(4-chlorobenzo)[e]-1,3,2-dioxaphosphepin-5-one with chloral (1:2) proceeds with evolving hexafluoroacetone and gives spiro{2-oxo-4-trichloromethyl-4,5-dihydro-2-phenyl-6,7-(4-chlorobenzo)[f]-1,3,2-dioxaphosphepine-5,2'-(3'-trichloromethyl)oxirane} with a high stereoselectivity. Configuration of the four chiral centres (P2 SC4 SC5 SC3' S /P2 RC4 RC5 RC3' R) was determined by a single crystal X-ray diffraction. © 2010

Novel Azo-Dyes-Modified Isatin Derivatives: Synthesis, UV/VIS Spectroscopic, and Electrochemical Study

© 2016 Wiley-VHCA AG, ZürichA high-yield and simple synthesis of certain aminomethylisatins bearing dye fragments via the Mannich reaction of isatin with amino-containing azobenzenes was reported. It was found that the absence of electron-donating groups in azo-dye molecule prevents aminomethylation of isatin. The effect of the incorporation of an isatin moiety with an azobenzene dye in one molecule on its absorption and electrochemical behavior was studied using UV spectroscopy and cyclic voltammetry

The formation of secondary arylphosphines in the reaction of organonickel sigma-complex [NiBr(Mes)(bpy)], where Mes = 2,4,6-trimethylphenyl, bpy = 2,2′-bipyridine, with phenylphosphine

© 2016 Taylor & Francis Group, LLC.The reactivity of organonickel sigma-complex [NiBr(Mes)(bpy)], where Mes = 2,4,6-trimethylphenyl, bpy = 2,2’-bipyridine towards phenylphosphine (PhPH2) has been investigated. It was found that this interaction leads to secondary mesitylphenylphosphine and dimesitylphosphine by formation of new carbon-phosphorus bond involving mesityl fragment of starting organonickel sigma-complex

Experimental and theoretical study on 6-substituted pyridoxine derivatives. Synthesis of Cyclic 2,4,5,6-Tetrakis-(hydroxymethyl)pyridin-3-ol Acetonides

© Pleiades Publishing, Ltd., 2011. Synthetic approaches to three cyclic 2,4,5,6-tetrakis(hydroxymethyl)pyridin-3-ol acetonides were developed. Among seven possible mono- and diketals, six-membered cyclic ketal incorporating the hydroxymethyl group in the 4-position turned out to be the most thermodynamically favorable. The experimental data were consistent with the results of quantum-chemical calculations of the Gibbs energies of formation of different acetonides. The structure of the isolated compounds was studied by X-ray diffraction

Conversion processes for high-viscosity heavy crude oil in catalytic and noncatalytic aquathermolysis

© 2014 Springer Science+Business Media. We have conducted experiments on noncatalytic and catalytic aquathermolysis of high-viscosity heavy crude oil from the Ashal'cha field (Tatarstan) in the presence of a crude oil-soluble nickel- and cobalt-containing catalyst, a proton donor, and a rock-forming mineral. We have identified the characteristic features of the change in the constituent composition, the hydrocarbon composition, and the fractional composition, the rheological properties of the crude oils, the average molecular weight of the asphaltenes for catalytic and noncatalytic conversion processes. For catalytic aquathermolysis, we established significant de novo formation of light 70°C-250°C fractions (by 23 wt.%), n-alkylbenzenes, an increase in the oil content by a factor of 1.3, a decrease in the resin content by a factor of 1.7, and a decrease in the viscosity by 98 rel.%. The major difference between the conversion of crude oil in the presence of the catalyst and the proton donor involves activation of degradation reactions at C-C, C-N, C-O, C-S bonds and blocking of polymerization reactions and accordingly less coke formation. We observed sorption of the catalyst components on rock