Boundedness properties of fermionic operators

The fermionic second quantization operator $d\Gamma(B)$ is shown to be bounded by a power $N^{s/2}$ of the number operator $N$ given that the operator $B$ belongs to the $r$-th von Neumann-Schatten class, $s=2(r-1)/r$. Conversely, number operator estimates for $d\Gamma(B)$ imply von Neumann-Schatten conditions on $B$. Quadratic creation and annihilation operators are treated as well.Comment: 15 page

3D sedimentary architecture showing the inception of an Ice Age

Abstract: Northeast Atlantic climate shifted into the Quaternary Ice Age around 2.6 M yr ago. Until now, however, the detailed changes associated with this inception of an Ice Age have remained obscure. New high-quality three-dimensional seismic data reveal a detailed geological record of buried surfaces, landforms and sedimentary architecture over vast parts of the Norwegian North Sea. Here, we show the sequence of near-coast geological events spanning the Northeast Atlantic inception of an Ice Age. We identify the location of immediate pre-glacial fluvially derived sandy systems where rivers from the Norwegian mainland built marine deltas. The stratigraphic position of a large submarine channel, formed by enhanced meltwater from initial build-up of local glaciers, is also shown. Finally, we document the transition to full ice-sheet growth over Scandinavia from the ice sheet’s earliest position to the later pattern of debris-flow lobes reaching the present-day shelf edge

Applications of Canonical Transformations

Canonical transformations are defined and discussed along with the exponential, the coherent and the ultracoherent vectors. It is shown that the single-mode and the $n$-mode squeezing operators are elements of the group of canonical transformations. An application of canonical transformations is made, in the context of open quantum systems, by studying the effect of squeezing of the bath on the decoherence properties of the system. Two cases are analyzed. In the first case the bath consists of a massless bosonic field with the bath reference states being the squeezed vacuum states and squeezed thermal states while in the second case a system consisting of a harmonic oscillator interacting with a bath of harmonic oscillators is analyzed with the bath being initially in a squeezed thermal state.Comment: 14 page

3D sedimentary architecture showing the inception of an Ice Age

Abstract: Northeast Atlantic climate shifted into the Quaternary Ice Age around 2.6 M yr ago. Until now, however, the detailed changes associated with this inception of an Ice Age have remained obscure. New high-quality three-dimensional seismic data reveal a detailed geological record of buried surfaces, landforms and sedimentary architecture over vast parts of the Norwegian North Sea. Here, we show the sequence of near-coast geological events spanning the Northeast Atlantic inception of an Ice Age. We identify the location of immediate pre-glacial fluvially derived sandy systems where rivers from the Norwegian mainland built marine deltas. The stratigraphic position of a large submarine channel, formed by enhanced meltwater from initial build-up of local glaciers, is also shown. Finally, we document the transition to full ice-sheet growth over Scandinavia from the ice sheet’s earliest position to the later pattern of debris-flow lobes reaching the present-day shelf edge

A persistent Norwegian Atlantic Current through the Pleistocene glacials

Changes in ocean‐circulation regimes in the northern North Atlantic and the Nordic Seas may affect not only the Arctic but potentially hemispheric or even global climate. Therefore, unraveling the long‐term evolution of the North Atlantic Current‐Norwegian Atlantic Current system through the Pleistocene glaciations could yield useful information and climatological context for understanding contemporary changes. In this work, ~50,000 km2 of 3‐D seismic reflection data are used to investigate the Pleistocene stratigraphy for evidence of paleo‐oceanographic regimes on the mid‐Norwegian margin since 2.58 Ma. Across 33 semicontinuous regional paleo‐seafloor surfaces ~17,500 iceberg scours have been mapped. This mapping greatly expands our spatiotemporal understanding of currents and iceberg presence in the eastern Nordic Seas. The scours display a dominant southwest‐northeast trend that complements previous sedimentological and numerical modeling studies that suggest northward‐flowing currents in the Norwegian Sea during the Pleistocene. This paleo‐oceanographic study suggests that through many of the Pleistocene glaciations, the location of surface ocean currents in the Norwegian Sea and, by extension, the eastern North Atlantic, were broadly similar to the present

Site-specific incorporation of phosphotyrosine using an expanded genetic code.

Access to phosphoproteins with stoichiometric and site-specific phosphorylation status is key to understanding the role of protein phosphorylation. Here we report an efficient method to generate pure, active phosphotyrosine-containing proteins by genetically encoding a stable phosphotyrosine analog that is convertible to native phosphotyrosine. We demonstrate its general compatibility with proteins of various sizes, phosphotyrosine sites and functions, and reveal a possible role of tyrosine phosphorylation in negative regulation of ubiquitination

Seabed geomorphology: a two-part classification system

The BGS has developed a two- part classification system (‘Morphology’ and ‘Geomorphology’) to facilitate work on a new ‘S eabed Geomorphology’ mapping initia tive, and this classification system is the focus of this report. As stated in the Foreword, the rationale and the basic framework of the classification system were conceived and es tablished within BGS, but recent collaboration within the MAREANO -Norway, INFOMAR -Ireland, and MAREMAP -UK (MIM) partnership has led to significant improvement of the classifi cation system, and this report. To further support this effort, existing BGS GIS tools (SIGMA) ha ve been adapted to apply this two-part classification system for more efficient geom orphological mapping in the marine environment. This report: provides a brief background on seabed mapping and characterisation, as well as how this science has been addressed historically within BGS; describes the current motiva tion to conduct seabed geom orphological mapping, and the requirement for a new set of t ools to facilitate this work; describes the logical framework that underpins the classification system; outlines the attributes of the classification system, how it can be applied, and discusses the advantages and limitations of the approach. It is anticipated that through testing and usage, the classification syst em will be revised and improved over time, with updated versions released through MIM partnershi p. It is also planned that a further ‘user guide’ report will be produced for the classifi cation system and the GIS tools, including thematic details (e.g. background information on ‘coastal’ or ‘glacial’ features) and a feature glossary

Population Pharmacokinetic Modelling of FE 999049, a Recombinant Human Follicle-Stimulating Hormone, in Healthy Women After Single Ascending Doses

OBJECTIVE: The purpose of this analysis was to develop a population pharmacokinetic model for a novel recombinant human follicle-stimulating hormone (FSH) (FE 999049) expressed from a human cell line of foetal retinal origin (PER.C6(®)) developed for controlled ovarian stimulation prior to assisted reproductive technologies.METHODS: Serum FSH levels were measured following a single subcutaneous FE 999049 injection of 37.5, 75, 150, 225 or 450 IU in 27 pituitary-suppressed healthy female subjects participating in this first-in-human single ascending dose trial. Data was analysed by nonlinear mixed effects population pharmacokinetic modelling in NONMEM 7.2.0.RESULTS: A one-compartment model with first-order absorption and elimination rates was found to best describe the data. A transit model was introduced to describe a delay in the absorption process. The apparent clearance (CL/F) and apparent volume of distribution (V/F) estimates were found to increase with body weight. Body weight was included as an allometrically scaled covariate with a power exponent of 0.75 for CL/F and 1 for V/F.CONCLUSIONS: The single-dose pharmacokinetics of FE 999049 were adequately described by a population pharmacokinetic model. The average drug concentration at steady state is expected to be reduced with increasing body weight