Structure of the magnetoionic medium around the FR Class I radio galaxy 3C 449

The goal of this work is to constrain the strength and structure of the magnetic field associated with the environment of the radio source 3C 449, using observations of Faraday rotation, which we model with a structure function technique and by comparison with numerical simulations. We assume that the magnetic field is a Gaussian, isotropic random variable and that it is embedded in the hot intra-group plasma surrounding the radio source. For this purpose, we present detailed rotation measure images for the polarized radio source 3C 449, previously observed with the Very Large Array at seven frequencies between 1.365 and 8.385 GHz. We quantify the statistics of the magnetic-field fluctuations by deriving rotation measure structure functions, which we fit using models derived from theoretical power spectra. We quantify the errors due to sampling by making multiple two-dimensional realizations of the best-fitting power spectrum.We also use depolarization measurements to estimate the minimum scale of the field variations. We then make three-dimensional models with a gas density distribution derived from X-ray observations and a random magnetic field with this power spectrum. Under these assumptions we find that both rotation measure and depolarization data are consistent with a broken power-law magnetic-field power spectrum, with a break at about 11 kpc and slopes of 2.98 and 2.07 at smaller and larger scales respectively. The maximum and minimum scales of the fluctuations are around 65 and 0.2 kpc, respectively. The average magnetic field strength at the cluster centre is 3.5 +/-1.2 micro-G, decreasing linearly with the gas density within about 16 kpc of the nucleus.Comment: 19 pages; 14 figures; accepted for publication on A&A. For a high quality version use ftp://ftp.eso.org/pub/general/guidetti

Clinical survey of neurosensory side-effects of mandibular parasymphyseal bone harvesting

The aim of the present survey was to assess neurosensory disturbances and/or tooth-pulp sensitivity losses after mandibular parasymphyseal bone-harvesting procedures. Twenty-eight harvesting areas in 16 patients were surveyed. Mucosal and skin sensitivity of the chin/lower lip, divided into four regions, were determined via Pointed-Blunt and Two-Point-Discrimination Tests. Pulp sensitivity of the mandibular teeth from the left second bicuspid to the right second bicuspid was tested by cold vitality preoperatively and 12 months postoperatively. Teeth were grouped according to sensitivity alterations and distance from the harvesting defects, as measured on CT scans, and statistically significant differences sought. At 12 months, 29% of preoperatively vital cuspids overlying the harvesting defects revealed pulp-sensitivity losses; no patient reported anaesthesia or analgesia; hypoaesthesia was present in 4% (8 sites; 2 patients), hypoalgesia was present in 3% (5 sites; 2 patients) and Two-Point-Discrimination Tests yielded pathologic responses in 5% of tested areas (10 sites; 4 patients). Teeth with and without pulp sensitivity changes were statistically indistinguishable regarding distances between root apices or mental foramen and the harvesting defect. The loss of pulp sensitivity in any tooth cannot be predicted simply on the basis of the distance between its apex and the harvesting osteotomy line

Ordered magnetic fields around radio galaxies: evidence for interaction with the environment

We present detailed imaging of Faraday rotation and depolarization for the radio galaxies 0206+35, 3C 270, 3C 353 and M 84, based on Very Large Array observations at multiple frequencies in the range 1365 to 8440 MHz. This work suggests a more complex picture of the magneto-ionic environments of radio galaxies than was apparent from earlier work. All of the sources show spectacular banded rotation measure (RM) structures with contours of constant RM perpendicular to the major axes of their radio lobes. We give a comprehensive description of the banded RM phenomenon and present an initial attempt to interpret it as a consequence of interactions between the sources and their surroundings. We show that the material responsible for the Faraday rotation is in front of the radio emission and that the bands are likely to be caused by magnetized plasma which has been compressed by the expanding radio lobes. A two-dimensional magnetic structure in which the field lines are a family of ellipses draped around the leading edge of the lobe can produce RM bands in the correct orientation for any source orientation. We also report the first detections of rims of high depolarization at the edges of the inner radio lobes of M 84 and 3C 270. These are spatially coincident with shells of enhanced X-ray surface brightness, in which both the field strength and the thermal gas density are likely to be increased by compression.Comment: 21 pages, 15 figures, accepted for publication in MNRAS. Full resolution paper available at http://www.ira.inaf.it/~guidetti/bands/ Subjects: Astrophysics (astro-ph

Cerebral hemodynamics on MR perfusion images before and after bypass surgery in patients with giant intracranial aneurysms

Preoperative assessment of the anatomy and dynamics of cerebral circulation for patients with giant intracranial aneurysm can improve both outcome prediction and therapeutic approach. The aim of our study was to use perfusion MR imaging to evaluate cerebral hemodynamics in such patients before and after extraintracranial high-flow bypass surgery. METHODS: Five patients with a giant aneurysm of the intracranial internal carotid artery underwent MR studies before, 1 week after, and 1 month after high-flow bypass surgery. We performed MR and digital subtraction angiography, and conventional and functional MR sequences (diffusion and perfusion). Surgery consisted of middle cerebral artery (MCA)-internal carotid artery bypass with saphenous vein grafts (n = 4) or MCA-external carotid artery bypass (n = 1). RESULTS: In four patients, MR perfusion study showed impaired hemodynamics in the vascular territory supplied by the MCA of the aneurysm side, characterized by significantly reduced mean cerebral blood flow (CBF), whereas mean transit time (MTT) and regional cerebral blood volume (rCBV) were either preserved, reduced, or increased. After surgery, angiography showed good canalization of the bypass graft. MR perfusion data obtained after surgery showed improved cerebral hemodynamics in all cases, with a return of CBF index (CBFi), MTT, and rCBV to nearly normal values. CONCLUSION: Increased MTT with increased or preserved rCBV can be interpreted as a compensatory vasodilatory response to reduced perfusion pressure, presumably from compression and disturbed flow in the giant aneurysmal sac. When maximal vasodilation has occurred, however, the brain can no longer compensate for diminished perfusion by vasodilation, and rCBV and CBFi diminish. Bypass surgery improves hemodynamics, increasing perfusion pressure and, thus, CBFi. Perfusion MR imaging can be used to evaluate cerebral hemodynamics in patients with intracranial giant aneurysm.BACKGROUND AND PURPOSE: Preoperative assessment of the anatomy and dynamics of cerebral circulation for patients with giant intracranial aneurysm can improve both outcome prediction and therapeutic approach. The aim of our study was to use perfusion MR imaging to evaluate cerebral hemodynamics in such patients before and after extraintracranial high-flow bypass surgery. METHODS: Five patients with a giant aneurysm of the intracranial internal carotid artery underwent MR studies before, 1 week after, and 1 month after high-flow bypass surgery. We performed MR and digital subtraction angiography, and conventional and functional MR sequences (diffusion and perfusion). Surgery consisted of middle cerebral artery (MCA)-internal carotid artery bypass with saphenous vein grafts (n = 4) or MCA-external carotid artery bypass (n = 1). RESULTS: In four patients, MR perfusion study showed impaired hemodynamics in the vascular territory supplied by the MCA of the aneurysm side, characterized by significantly reduced mean cerebral blood flow (CBF), whereas mean transit time (MTT) and regional cerebral blood volume (rCBV) were either preserved, reduced, or increased. After surgery, angiography showed good canalization of the bypass graft. MR perfusion data obtained after surgery showed improved cerebral hemodynamics in all cases, with a return of CBF index (CBFi), MTT, and rCBV to nearly normal values. CONCLUSION: Increased MTT with increased or preserved rCBV can be interpreted as a compensatory vasodilatory response to reduced perfusion pressure, presumably from compression and disturbed flow in the giant aneurysmal sac. When maximal vasodilation has occurred, however, the brain can no longer compensate for diminished perfusion by vasodilation, and rCBV and CBFi diminish. Bypass surgery improves hemodynamics, increasing perfusion pressure and, thus, CBFi. Perfusion MR imaging can be used to evaluate cerebral hemodynamics in patients with intracranial giant aneurysm

Effects of add-on ultramicronized n-palmitol ethanol amide in patients suffering of migraine with aura. a pilot study

Background: Palmitoyl ethanol amide (PEA) is an endogenously produced substance showing anti-nociceptive effect through both receptor and non-receptor mediated effects at the level of different cellular and tissue sites. This study showed the results of a single blind study that was conducted to evaluate both the safety and the efficacy of ultramicronized PEA (umPEA; 1,200 mg/day) for up 90 days in patients suffering of Migraine with Aura (MA) treated with NSAIDs. Methods: A total of 20 patients, 8 male (33-56-years, average 41.4 ± 7.8) and 12 female (19-61-years, average 38.5 ± 11.9) with MA were admitted to our observation and diagnosed according to ICHD-3 criteria, they received umPEA (1,200 mg/day) in combination with NSAIDs for up to 90 days. They were revaluated at 30, 60, and 90 days after treatment. Results: umPEA administration induced a statistically significant and time dependent pain relief. In particular, these effects were evident at 60 days (male P = 0.01189; female P = < 0.01) and they lasted until the end of the study (male P = 0.0066; female P = 0.01473). Conclusion: Although further studies are needed, our findings indicate that in patients suffering of MA treatment with umPEA had good efficacy and safety which candidate this compound as a therapeutic tool in pain migraine management

Volume changes of grafted autogenous bone in sinus augmentation procedure

to evaluate associations between the osseous remodelling add 3-dimensional features of both the grafted bone and the recipient site as well as the density of the grafted bone,and to assess the relation between the degree of bone resorption and the type of autogenous bone.grafting procedure or the source(block or particulate bone from iliac crest or block bone from chin

Physical activity and hypocaloric diet recovers osteoblasts homeostasis in women affected by abdominal obesity.

Obesity is a multifactorial disease linked to metabolic chronic disorders such as diabetes, and hypertension. Also, it has recently been associated with skeletal alterations and low bone mineral density. We previously demonstrated that exposure of osteoblasts to sera of sedentary subjects affected by obesity alters cell homeostasis in vitro, leading to disruption of intracellular differentiation pathways and cellular activity. Thus, the purpose of the present study has been to evaluate whether sera of sedentary obese women, subjected to physical activity and hypocaloric diet, could recover osteoblast homeostasis in vitro as compared to the sera of same patients before intervention protocol. To this aim, obese women were evaluated at time 0 and after 4, 6, and 12 months of individualized prescribed physical activity and hypocaloric diet. Dual-energy-X-ray absorptiometry measurements were performed at each time point, as well as blood was collected at the same points. Cells were incubated with sera of subjects before and after physical activity as described: obese at baseline and after for 4, 6, and 12 months of physical activity and nutritional protocol intervention. Osteoblasts exposed to sera of patients, who displayed increased lean and decreased fat mass (from 55.5 ± 6.5 to 57.1 ± 5.6% p ≤ 0.05; from 44.5 ± 1.1 to 40.9 ± 2.6% p ≤ 0.01 respectively), showed a time-dependent increase of Wnt/β-catenin signaling, versus cells exposed to sera of obese patients before intervention protocol, suggesting recovery of osteoblast homeostasis upon improvement of body composition. An increase in β-catenin nuclear accumulation and nuclear translocation was also observed, accompanied by an increase in Adiponectin receptor 1 protein expression, suggesting positive effect on cell differentiation program. Furthermore, a decrease in sclerostin amount and an increase of type 1 procollagen amino-terminal-propeptide were depicted as compared to baseline, proportionally to the time of physical activity, suggesting a recovery of bone remodeling modulation and an increase of osteoblast activity induced by improvement of body composition. In conclusion, our results show for the first time that sera of obese sedentary women who increased lean mass and decreased fat mass, by physical activity and hypocaloric diet, rescue osteoblasts differentiation and activity likely due to a reactivation of Wnt/β-catenin-pathway, suggesting that a correct life style can improve skeletal metabolic alteration induced by obesity

Constrangimento mecânico provocado pela válvula aquatrainer® associada ao sistema de oximetria directa (K4 B2) na cinemática de crol

O estudo teve como objectivo determinar o constrangimento cinemático provocado pela válvula de treino Aquatrainer® (Cosmed, Roma, Itália), integrada com o sistema portátil analisador de gases K4 b2 (Cosmed, Roma, Itália), durante um esforço máximo na técnica de Crol. O protocolo consistiu na realização de dois percursos à intensidade máxima de 100 m Crol, em piscina de 50 metros: um percurso com o sistema de oximetria acoplado e outro em nado livre (sem o sistema) e um intervalo mínimo de 48 horas por seis crolistas. Duas câmaras registaram respectivamente imagens aéreas e subaquáticas no plano sagital. Foi efectuada a análise cinemática (Ariel Performance Analysis System, Ariel Dynamics Inc., Califórnia, EUA) de um ciclo gestual completo, através de um leitor de vídeo a 50 Hz (Panasonic, AG 7355, Japão). A duração do teste foi significativamente superior no nado constrangido do que no nado livre (P = 0.04). Sem a válvula os nadadores cumpriram os 100 metros em 95.24 ± 2.18 % do seu recorde pessoal e com a válvula a 90.99 ± 2.86 %. As restantes variáveis não apresentaram diferenças significativas entre as duas condições de exercitação. Verificou-se uma tendência para a frequência gestual (-1.58 %), distância de ciclo (-3.62 %), a velocidade de nado (-5.75 %), a a flutuação da velocidade do centro de massa (-2.21 %) e o índice de nado (-9.27 %) serem inferiores com a utilização da válvula. Já a o período do ciclo foi superior no nado constrangido do que no nado livre (1.63 %)

The intracluster magnetic field power spectrum in A2199

We investigate the magnetic field power spectrum in the cool core galaxy cluster A2199 by analyzing the polarized emission of the central radio source 3C338. The polarized radiation from the radio emitting plasma is modified by the Faraday rotation as it passes through the magneto-ionic intracluster medium. We use Very Large Array observations between 1665 and 8415 MHz to produce detailed Faraday rotation measure and fractional polarization images of the radio galaxy. We simulate Gaussian random three-dimensional magnetic field models with different power-law power spectra and we assume that the field strength decreases radially with the thermal gas density as n_e^{\eta}. By comparing the synthetic and the observed images with a Bayesian approach, we constrain the strength and structure of the magnetic field associated with the intracluster medium. We find that the Faraday rotation toward 3C338 in A2199 is consistent with a magnetic field power law power spectrum characterized by an index n=(2.8 \pm 1.3) between a maximum and a minimum scale of fluctuation of \Lambda_{max}=(35 \pm 28) kpc and \Lambda_{min}=(0.7 \pm 0.1) kpc, respectively. By including in the modeling X-ray cavities coincident with the radio galaxy lobes, we find a magnetic field strength of =(11.7 \pm 9.0) \mu G at the cluster center. Further out, the field decreases with the radius following the gas density to the power of \eta=(0.9 \pm 0.5).Comment: 17 pages, 12 figures, A&A accepte