Bilateral vocal cord abductor paralysis associated with primary herpes simplex infection: A case report

International audienc

Sinonasal mucosal melanomas

SummaryObjectivesSinonasal mucosal melanomas account for approximately 1% of all melanomas. These tumors are particularly aggressive, with a recurrence rate between 37 and 54% and a 5-year survival rate between 20 and 46%. Metastases are frequent. The main objective of this study was to analyze all of our cases of sinonasal mucosal melanomas and determine any prognostic factors.Patients and methodsAll our cases of sinonasal mucosal melanoma over a period of 10 years were included. Ten cases were analyzed. The mean age was 71 years (range: 61–85 years) for seven women and three men. The clinical, radiological, anatomopathological, and surgical data as well as the characteristics of disease progression were analyzed. These data were compared to those reported in the literature.ResultsThe mean follow-up was 36.3 months (range: 2–96 months). The 5-year overall survival was 40%. Seven patients developed local recurrences after a mean follow-up of 16 months (range: 2–27 months) with associated metastases in three cases. Analysis of the prognostic factors showed that tumors classified as T1 and limited to the nasal fossae had a better prognosis.ConclusionSinonasal mucosal melanomas are rare tumors with a high mortality rate. Treatment of these tumors requires extensive surgical treatment associated with external radiotherapy

Craniofacial fibrous dysplasia: A 10-case series

International audienceObjective: Fibrous dysplasia of bone is a rare sporadic benign congenital condition in which normal cancellous bone is replaced by fibro-osseous tissue with immature osteogenesis. Sarcomatous transformation is exceptional. Lesions may involve one bone (monostotic) or several (polyostotic). Fibrous dysplasia may be associated with cafe-au-lait skin macules and endocrinopathy in McCune-Albright syndrome, or with myxoma in Mazabraud's syndrome. Methods: We report ten cases of patients followed up for craniofacial fibrous dysplasia in our center between 2010 and 2015. Results: Mean age was 43 years (range, 10-72 years). Clinical symptoms comprised headache (n = 3) and sensorineural disorder: recurrent anterior uveitis (n = 1), visual acuity loss, epiphora and vestibular syndrome (n = 1), and hearing loss (n = 1). All cases were monostotic. The sphenoid bone was most commonly involved (n = 5), followed by the ethmoid (n = 1), frontal (n = 1), fronto-ethmoid (n = 1), temporal (n = 1) and fronto-ethmoido-sphenoid (n = 1) bones. Five patients were treated with intravenous pamidronate, a bisphosphonate: evolution was favorable for 3 of them at 1-6 months after treatment initiation, with resolution of headache or vestibular syndrome; the other 2 patients were stable. Two patients were operated on. Conclusion: Diagnosis of craniofacial fibrous dysplasia should be considered in case of headache, neuralgia, sensory disorder, functional disorder or infectious ENT complications. A medico-surgical approach is useful for these patients

Malignant melanoma of the nasal septum, a rare tumor, occurring in a 54-year-old patient after hereditary retinoblastoma treatment

Windinmanégdé Pierre Djiguimdé,1 Ibrahim Abib Diomandé,2 Nicolas Bonnin,3 Nicolas Saroul,4 Abdoulaye Touré,5 Jérôme Sanou,1 Paté Sankara,1 Marc Russier,4 Laurent Gilain,4 Ahgbatouhabéba Ahnoux-Zabsonré,1 Nonfounikoun Meda,1 Franck Bacin3 1Ophthalmology Department, University Hospital Yalgado Ouédraogo, Ouagadougou, Burkina Faso, 2Ophthalmology Department, University Hospital of Bouaké, University Alassane Ouattara, Bouaké, Cote d'Ivoire, 3Ophthalmology Department, 4Otorhinolaryngology Department, University Hospital Clermont-Ferrand, Clermont-Ferrand, France; 5Radiology Department, University Hospital of Yopougon, University Félix Houphouët Boigny, Abidjan, Côte d'Ivoire Abstract: The authors report a case of a malignant melanoma of the nasal cavity that is a rare tumor and very aggressive, constituting 1% of all melanomas. It appeared in a patient 54 years after he was treated for a hereditary retinoblastoma. Its symptoms are nonspecific, and often marked by epistaxis. Its diagnosis is histological, supported by immunohistochemistry. Its prognosis is often unfavorable, and characterized by the occurrence of metastases and recurrences. Because of the risk of secondary cancer that exists in any survivor of hereditary retinoblastoma, we must think of possible mucosal melanoma of the nasal sinus in these patients in cases of chronic epistaxis. The prognosis of this tumor depends on its early diagnosis and surgical treatment. Keywords: retinoblastoma, epistaxis, immunohistochemistry, nasosinusal melanoma, hereditary cancer&nbsp