Assessment of investments towards digitalised production

Since 2011 the term “Industrie 4.0” represents the process of digital transformation for industrial production. The discussion in regard to this transformation is dominated by technological aspects but neglects the economical rational for investments in many cases. However, the necessary investments in digitalised technical equipment creates new challenges in solid judgement on ROI and priorities. The complexity related to digital transformation confronts companies with new aspects of uncertainty. Therefore, a paradox situation is observed by a “digital gap” between investment in technology and where the added value is captured and monetised. This thesis investigates how complexity of digitalisation, respectively the “digital gap” can be understood and bridged by the usage of value-constructs originated from recent business model research. The moderating role of constructs like value proposition, value network and value capture towards decision for investments is investigated in relation with digitalisation initiatives, technology and measurement of industrial productivity. Based on differences between industries in their digital maturity level the survey primarily focuses on Food, Beverage, Pharma, Life science and FMCG companies. A second survey sample covers other industries, mainly machine builders and automotive companies, to see differences or possible generalisable elements in the results. The research method is based on a mixed-method design, combining qualitative research results with quantitative analyses by triangulation. An intensive literature research of four related scientific disciplines delivers theory for the paradigmatic coding and formulation of a Grounded Theory. The results of Grounded Theory deliver the theoretical rational to build a structural model to use within statistical factor analysis methods. The thesis delivers a wide range of results and insights into the complex relations of transformation within the context of digitalised production. It shows innovative research design in using value-constructs for the moderation of value within an organisation. Finally, the mixed-method design complements the results by the combination of diverse disciplines of science. Results to explain how moderation of value does bridge the “digital gap”, how data is enabling monetisation of value generated and how standardisation shows relevance in successful investments are delivered within the thesis

Climate Change Impacts on Corn Phenology and Productivity

Global climate is changing and will impact future production of all food and feed crops. Corn is no exception and to ensure a future supply we must begin to understand how climate impacts both the phenological development of corn and the productivity. Temperature and precipitation are the two climate factors that will have a major benefit on corn phenology and productivity. The warming climate will accelerate the phenological development because the number of thermal units required for leaf appearance is relatively constant in the vegetative stage. Productivity of corn is reduced when extreme temperature events occur during pollination and is further exaggerated when there are water deficits at pollination. During the grain-filling period, warm temperatures above the upper threshold cause a reduction in yield. Model estimates suggest that for every 1°C increase in temperature there is nearly a 10% yield reduction. To meet world demand, new adaptation practices are needed to provide water to the growing crop and avoid extreme temperature events during the growing season. Climate change will continue to affect corn production and understanding these effects will help determine where future production areas exist and innovative adaptation practices to benefit yield stability could be utilized

Making precise predictions of the Casimir force between metallic plates via a weighted Kramers-Kronig transform

The possibility of making precise predictions for the Casimir force is essential for the theoretical interpretation of current precision experiments on the thermal Casimir effect with metallic plates, especially for sub-micron separations. For this purpose it is necessary to estimate very accurately the dielectric function of a conductor along the imaginary frequency axis. This task is complicated in the case of ohmic conductors, because optical data do not usually extend to sufficiently low frequencies to permit an accurate evaluation of the standard Kramers-Kronig integral used to compute $\epsilon(i \xi)$. By making important improvements in the results of a previous paper by the author, it is shown that this difficulty can be resolved by considering suitable weighted dispersions relations, which strongly suppress the contribution of low frequencies. The weighted dispersion formulae presented in this paper permit to estimate accurately the dielectric function of ohmic conductors for imaginary frequencies, on the basis of optical data extending from the IR to the UV, with no need of uncontrolled data extrapolations towards zero frequency that are instead necessary with standard Kramers-Kronig relations. Applications to several sets of data for gold films are presented to demonstrate viability of the new dispersion formulae.Comment: 18 pages, 15 encapsulated figures. In the revised version important improvements have been made, which affect the main conclusions of the pape

Seeing the wood for the trees: the role of woody resources for the construction of gender specific household cultural artefacts in non-traditional communities in the Eastern Cape, South Africa

There is a growing wealth of data capturing the direct-use values of the environment and recognition of forests and wild resources as representing ‘‘the poor man’s overcoat’’. This focus has however resulted in an emphasis on the utilitarian values of wild resources for rural livelihoods and has for the most part overlooked their cultural values. In tangent to these developments within the field of anthropology there has been increased attention directed towards the relationship between biodiversity and human diversity over the past decade. This has resulted in the recognition of what the Declaration of Belem calls an ‘inextricable link’ between biological and cultural diversity. The term bio-cultural diversity has been introduced as a concept denoting this link. Consequently there is a need for more elaborate assessments of the various ways in which different groups of people find value in biodiversity. The aim of this paper is to demonstrate the cultural significance of wild harvested plant resources for the maintenance of two gender specific cultural artefacts for amaXhosa people in South Africa, to assess the persistence of these practices in rapidly modernizing communities. We demonstrate the endurance of these ancient cultural artefacts in present-day peri-urban communities and suggest that they point to the need for improved understanding of the significance of bio-cultural diversity. The findings of the study should not be interpreted as illustrating stagnation in the traditional past, but rather as pointing at the need for improved understanding of the significance of bio-cultural diversity in a dynamic sense

Boceprevir in combination with HIV protease inhibitors in patients with advanced fibrosis-altered drug-drug interactions?

In HIV/HCV co-infected patients improved treatment outcomes have been reported for the HCV protease inhibitors (PIs) boceprevir (BOC) and telaprevir (TVR), reaching SVR rates of up to 70% in pilot trials. Due to complex drug-drug-interactions triple therapy is substantially limited in HIV/HCV-coinfected individuals. Co-administration of BOC with the commonly available HIV PIs has been reported not only to decrease the level of BOC but also to lead to relevant decreases in the respective HIV PI. Here, we report on two patients who received BOC-containing HCV triple therapy in combination with a HIV PI. Patient 1 was on darunavir 800 mg/ritonavir 100 mg once-daily mono-therapy. Using FibroScan a liver stiffness of 34 kPa suggested liver cirrhosis prior to start of HCV triple therapy. At week 5 of HCV triple therapy darunavir trough concentration was measured in the reference range with 3777 ng/ml (reference trough concentration 2400–4600 ng/ml). HCV-RNA became negative at week 10 and HIV-RNA was below detection limit (<40 copies/ml) at all times. Patient 2 was on a simplified FTC qd and fos-amprenavir 700 mg/ritonavir 100 mg bid regimen. Liver disease had also progressed to liver cirrhosis, confirmed in FibroScan, with a liver stiffness of 32 kPa. At week 8 of HCV triple therapy fos-amprenavir trough level was measured in the normal reference range with 1699 ng/ml (reference trough concentration 750–2500 ng/ml). At week 11 HCV-RNA was <12 IU/ml and HIV viral load was below detection limit of <40 copies/ml at all times. Our clinical data suggest that in patients with advanced liver disease possibly drug levels of HIV PIs which are coadministered with BOC may be within the normal range. In order to better understand the true amount of drug interactions between BOC and commonly used HIV PIs in HIV/HCV-coinfected patients with more advanced liver fibrosis, urgently more PK studies are required to make HCV triple therapy accessible for a wider number of HIV/HCV-coinfected patients in desperate need of these drugs

Kappia lobulata (Apocynaceae, Periplocoideae), a new genus from South Africa

Kappia, a new genus from the Fish River Valley in the Eastern Cape Province, South Africa is presented. At first described as Raphionacme lobulata Venter and R.L.Verh. [Venter, H.J.T., Verhoeven, R.L. 1988. Raphionacme lobulata (Periplocaceae), a new species from the eastern Cape Province, South Africa. South African Journal of Botany 54, 603–606.] based on a single specimen collected in 1936, recently discovered plants of this species proved it to be a new genus. In habit Kappia resembles Baseonema Schltr. and Rendle, Batesanthus N.E.Br., Mondia Skeels and Stomatostemma N.E.Br. However, as far as floral structure is concerned, Kappia reveals more affinity with Raphionacme Harv. DNA sequence data show Kappia to be distinct from Batesanthus, Mondia and Raphionacme Harv. and weakly supported as a sister to Stomatostemma

Water-Use Efficiency: Advances and Challenges in a Changing Climate

Water use efficiency (WUE) is defined as the amount of carbon assimilated as biomass or grain produced per unit of water used by the crop. One of the primary questions being asked is how plants will respond to a changing climate with changes in temperature, precipitation, and carbon dioxide (CO2) that affect their WUE At the leaf level, increasing CO2 increases WUE until the leaf is exposed to temperatures exceeded the optimum for growth (i.e., heat stress) and then WUE begins to decline. Leaves subjected to water deficits (i.e., drought stress) show varying responses in WUE. The response of WUE at the leaf level is directly related to the physiological processes controlling the gradients of CO2 and H2O, e.g., leaf:air vapor pressure deficits, between the leaf and air surrounding the leaf. There a variety of methods available to screen genetic material for enhanced WUE under scenarios of climate change. When we extend from the leaf to the canopy, then the dynamics of crop water use and biomass accumulation have to consider soil water evaporation rate, transpiration from the leaves, and the growth pattern of the crop. Enhancing WUE at the canopy level can be achieved by adopting practices that reduce the soil water evaporation component and divert more water into transpiration which can be through crop residue management, mulching, row spacing, and irrigation. Climate change will affect plant growth, but we have opportunities to enhance WUE through crop selection and cultural practices to offset the impact of a changing climate

Combustion waves in a model with chain branching reaction and their stability

In this paper the travelling wave solutions in the adiabatic model with two-step chain branching reaction mechanism are investigated both numerically and analytically in the limit of equal diffusivity of reactant, radicals and heat. The properties of these solutions and their stability are investigated in detail. The behaviour of combustion waves are demonstrated to have similarities with the properties of nonadiabatic one-step combustion waves in that there is a residual amount of fuel left behind the travelling waves and the solutions can exhibit extinction. The difference between the nonadiabatic one-step and adiabatic two-step models is found in the behaviour of the combustion waves near the extinction condition. It is shown that the flame velocity drops down to zero and a standing combustion wave is formed as the extinction condition is reached. Prospects of further work are also discussed.Comment: pages 32, figures 2