Joint computation offloading, resource allocation and content caching in cellular networks with mobile edge computing

Mobile edge computing (MEC) has risen as a promising technology to augment computational capabilities of mobile devices. Meanwhile, in-network caching has become a natural trend of the solution of handling exponentially increasing Internet traffic. The important issues in these two networking paradigms are computation offloading and content caching strategies, respectively. In order to jointly tackle these issues, we formulate an optimization problem in wireless cellular networks with mobile edge computing, taking into consideration computation offloading decision, physical spectrum resource allocation, MEC computation resource allocation, and content caching strategy. Furthermore, we transform the original problem into a convex problem and then decompose it in order to solve it in a distributed and efficient way. Finally, with recent advances in distributed convex optimization, we develop an alternating direction method of multipliers (ADMM) based algorithm to solve the optimization problem. The effectiveness

Computation Offloading and Resource Allocation in Wireless Cellular Networks with Mobile Edge Computing

Mobile edge computing has risen as a promising technology for augmenting the computational capabilities of mobile devices. Meanwhile, in-network caching has become a natural trend of the solution of handling exponentially increasing Internet traffic. The important issues in these two networking paradigms are computation offloading and content caching strategies, respectively. In order to jointly tackle these issues in wireless cellular networks with mobile edge computing, we formulate the computation offloading decision, resource allocation and content caching strategy as an optimization problem, considering the total revenue of the network. Furthermore, we transform the original problem into a convex problem and then decompose it in order to solve it in a distributed and efficient way. Finally, with recent advances in distributed convex optimization, we develop an alternating direction method of multipliers-based algorithm to solve the optimization problem. The effectiveness of the proposed scheme is demo

Joint Computation Offloading and Interference Management in Wireless Cellular Networks with Mobile Edge Computing

Mobile edge computing (MEC) has attracted great interests as a promising approach to augment computational capabilities of mobile devices. An important issue in the MEC paradigm is computation offloading. In this paper, we propose an integrated framework for computation offloading and interference management in wireless cellular networks with MEC. In this integrated framework, we formulate the computation offloading decision, physical resource block (PRB) allocation, and MEC computation resource allocation as optimization problems. The MEC server makes the offloading decision according to the local computation overhead estimated by all user equipments (UEs) and the offloading overhead estimated by the MEC server itself. Then, the MEC server performs the PRB allocation using the graph coloring method. The outcomes of the offloading decision and PRB allocation are then used to distribute the computation resource of the MEC server to the UEs. Simulation results are presented to show the effectiveness of the p

Nanoparticle-mediated corneal neovascularization treatments:Toward new generation of drug delivery systems

Corneal neovascularization (CNV) is one of the major factors for vision impairment and blindness worldwide. The current treatment for CNV focuses primarily on topical eyedrops of glucocorticoids, non-steroidal anti-inflammatory drugs, electro-coagulation and laser photo-coagulation. Unfortunately, coagulation-based treatment is restricted by corneal hemorrhage and iris atrophy. And drug treatments have limited therapeutic effects and a short duration of action. Nanoparticle-based drug delivery systems are widely applied due to their improved pharmacokinetics, optimized drug targeting and enhanced biocompatibility. In this article, we provide a comprehensive and systematic overview of the CNV nanodrug system, highlighting some of the recent advances in nanodrug design, preparation, and functional modification. Moreover, we discuss the challenges in the clinical translation and potential risks in CNV treatment. A greater effort is needed for the potential applications of nanotechnology in the field of ophthalmology