2,060 research outputs found
Biomarkers of Acute Myocardial Infarction in the Elderly: Troponin and Beyond
In the broadest context, biological markers, or biomarkers, are molecules that characterize a biological system or process. In the setting of cardiovascular disease, a number of biomarkers have become an integral part of diagnostic and risk stratification strategies. In this review, we will discuss classic and emerging biomarkers of cardiovascular disease and the role of these biomarkers in the diagnosis and prognosis of elderly patients presenting with acute myocardial infarction
FIMO: scanning for occurrences of a given motif
Summary: A motif is a short DNA or protein sequence that contributes to the biological function of the sequence in which it resides. Over the past several decades, many computational methods have been described for identifying, characterizing and searching with sequence motifs. Critical to nearly any motif-based sequence analysis pipeline is the ability to scan a sequence database for occurrences of a given motif described by a position-specific frequency matrix
Life History of the Spider, Phidippus Audax (Hentz), in Relation to Biological Control of Grain Sorghum Insects
Entomolog
The Risk of Exposure to Diagnostic Ultrasound in Postnatal Subjects
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135382/1/jum2008274565.pd
Better the donor you know?:A qualitative study of renal patients' views on âaltruisticâ live-donor kidney transplantation
AbstractBackgroundIn the UK there is a short-fall between individuals requiring a renal transplant and kidneys available for transplantation. Non-directed âaltruisticâ living kidney donation has emerged as a strategy for bridging this gap between supply and demand, with the number increasing each year.ObjectiveThis study aimed to explore the views of potential recipients towards non-directed âaltruisticâ live-donor kidney transplantation.MethodsSemi-structured interviews with 32 UK deceased-donor kidney transplant recipients were performed. Interviews explored willingness to consider directed and non-directed live-donor kidney transplants (LDKTs). Interviews were recorded, transcribed verbatim and transcripts were analysed using the constant comparison method described in Grounded Theory.ResultsFor those not willing to accept a non-directed âaltruisticâ LDKT, the following themes were identified: i) Prioritising other recipients above self; ii) Fear of acquiring an unknown donor's characteristics, and iii) Concern for the donor â unnecessary risk. For those willing to accept a non-directed âaltruisticâ LDKT the following themes were identified: iv) Prioritising known above unknown persons, v) Belief that they are as deserving as other potential recipients, and vi) Advantages of a LDKT.ConclusionsDrawing on âgift exchange theoryâ, this study contributes to our understanding of the experience of the intended recipient of a gift. The anonymity of the donor-recipient appears to be seen as a benefit of non-directed âaltruisticâ live-donor transplants, freeing recipients from the obligations of the gift. However, those who feel unworthy of the âgifted transplantâ are concerned about the donor and by the lack of opportunity for direct reciprocity. Highlighting the âreciprocal benefitsâ reported by donors may allow individuals whose preference is a live-donor transplant to accept one if offered. These insights provide the transplant community with targets for intervention, through which the concerns of potential recipients might be addressed
Genomic analysis of early murine mammary gland development using novel probe-level algorithms
We describe a novel algorithm (ChipStat) for detecting gene-expression changes utilizing probe-level comparisons of replicate Affymetrix oligonucleotide microarray data. A combined detection approach is shown to yield greater sensitivity than a number of widely used methodologies including SAM, dChip and logit-T. Using this approach, we identify alterations in functional pathways during murine neonatal-pubertal mammary development that include the coordinate upregulation of major urinary proteins and the downregulation of loci exhibiting reciprocal imprinting
Geology of Niobrara State Park, Knox County, Nebraska, and Adjacent Areas, with a Brief History of the Park, Gavins Point Dam, and Lewis and Clark Lake
Location Niobrara State Park is located in northwestern Knox County, Nebraska, just west of the town of Niobrara and on the west side of the Niobrara River. The present park was opened in the summer of 1987. Mostly north of Nebraska Highway 12, the site is hilly with bluffs overlooking the Missouri and Niobrara rivers. Excellent facilities include paved roads, cabins, an outdoor swimming pooi, hiking trails, picnic and camping sites, horseback riding trails, playgrounds, restrooms, a group lodge, and an interpretive shelter. Many vantage points in the park have beautiful views of the lower Niobrara Valley and the middle Missouri Valley. Lovers of native plants and wildlife can see many different species in and near the park. Park grounds are open all year. The park office, about 1.5 miles northwest of the park entrance, is open daily from mid-April to mid-November, and weekdays at other times of the year (figs. 1 and 2).
Purposes This educational circular describes the prehistory and history of Niobrara State Park, Gavins Point Dam and its reservoir-Lewis and Clark Lake-and several aspects of the geology of the park and nearby or adjoining areas. Sections include information on minerals, fossils, stratigraphy, and geologic history, but the principal focuses of this circular are on the work of and changes in the Niobrara River and on geologic hazards in the area.
Cautions Caution is advised when visiting the park or any other area. A void walking on landslide areas. Stay away from steep hill slopes. Be careful when working on dark shale exposures on hot days because temperatures on these shales reach well above 100 degrees F. Poison ivy, stinging insects, and other such hazards occur. Be careful! We remind readers that collecting of any kind is prohibited in the park and that permission must be obtained from property owners before going on or collecting from private property
- âŠ