The Improvement of Durability of Reinforced Concretes for Sustainable Structures: A Review on Different Approaches

The topic of sustainability of reinforced concrete structures is strictly related with their durability in aggressive environments. In particular, at equal environmental impact, the higher the durability of construction materials, the higher the sustainability. The present review deals with the possible strategies aimed at producing sustainable and durable reinforced concrete structures in different environments. It focuses on the design methodologies as well as the use of unconventional corrosion-resistant reinforcements, alternative binders to Portland cement, and innovative or traditional solutions for reinforced concrete protection and prevention against rebars corrosion such as corrosion inhibitors, coatings, self-healing techniques, and waterproofing aggregates. Analysis of the scientific literature highlights that there is no preferential way for the production of “green” concrete but that the sustainability of the building materials can only be achieved by implementing simulta-neous multiple strategies aimed at reducing environmental impact and improving both durability and performances

Therapy-induced senescence upregulates antigen presentation machinery and triggers anti-tumor immunity in Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is an aggressive hematological malignancy often curable only by using intensive chemotherapy. Nonetheless, resistance/early relapses are frequent, underscoring the need to investigate the molecular events occurring shortly after chemotherapy. Therapy-induced senescence (TIS) is a fail-safe tumor suppressive mechanism that may elicit immune-mediated responses contributing to senescent cell clearance. Yet, TIS functional role in AML eradication and immune surveillance early post-chemotherapy remains ill-defined. By combining transcriptional and cellular-based evaluation of senescence markers in AML patient samples, we found upregulation of senescence-associated genes and interferon gene categories with concomitant induction of HLA class I and class II molecules, pointing to a causal link between TIS and leukemia immunogenicity. Consistently, senescence-competent AML samples activated autologous CD4+ and CD8+ T cells and improved leukemia recognition by both T-cell subsets. Lastly, the anti-leukemic activity of Immune Checkpoint Blockades (ICBs) was enhanced upon senescence engagement in AML. Altogether, our results identify senescence as a potent immune-related anti-leukemic mechanism that may rapidly translate into innovative senescence-based strategies to prevent AML relapse

L'influence de la propension à schématiser par marques sur une stratégie d 'alliance marque/label écologique

La stratégie d’alliance d’une marque et d’un label est de plus en plus répandue, mais celle-ci est coûteuse pour les entreprises qui doivent pouvoir s’assurer de son efficacité. Pour accroître les connaissances sur l’alliance marque/label, nous avons étudié l’influence de la schématisation par marques sur l’image d’un produit et l’intention d’achat. Les résultats montrent que la schématisation par marques modère l’influence de l’alliance marque/label écologique sur l’évaluation des attributs produit et l’intention d’achat pour une catégorie de produit ayant une bonne congruence produit/label. En effet, la stratégie d’alliance marque/label aura un effet positif sur l’évaluation des attributs du produit pour les individus qui schématisent peu. La schématisation par marques aura une influence positive sur l’intention d’achat quel que soit le produit présenté (avec ou sans alliance marque/label)