163 research outputs found
The Improvement of Durability of Reinforced Concretes for Sustainable Structures: A Review on Different Approaches
The topic of sustainability of reinforced concrete structures is strictly related with their durability in aggressive environments. In particular, at equal environmental impact, the higher the durability of construction materials, the higher the sustainability. The present review deals with the possible strategies aimed at producing sustainable and durable reinforced concrete structures in different environments. It focuses on the design methodologies as well as the use of unconventional corrosion-resistant reinforcements, alternative binders to Portland cement, and innovative or traditional solutions for reinforced concrete protection and prevention against rebars corrosion such as corrosion inhibitors, coatings, self-healing techniques, and waterproofing aggregates. Analysis of the scientific literature highlights that there is no preferential way for the production of âgreenâ concrete but that the sustainability of the building materials can only be achieved by implementing simulta-neous multiple strategies aimed at reducing environmental impact and improving both durability and performances
Therapy-induced senescence upregulates antigen presentation machinery and triggers anti-tumor immunity in Acute Myeloid Leukemia
Acute myeloid leukemia (AML) is an aggressive hematological malignancy often curable only by using intensive chemotherapy. Nonetheless, resistance/early relapses are frequent, underscoring the need to investigate the molecular events occurring shortly after chemotherapy. Therapy-induced senescence (TIS) is a fail-safe tumor suppressive mechanism that may elicit immune-mediated responses contributing to senescent cell clearance. Yet, TIS functional role in AML eradication and immune surveillance early post-chemotherapy remains ill-defined. By combining transcriptional and cellular-based evaluation of senescence markers in AML patient samples, we found upregulation of senescence-associated genes and interferon gene categories with concomitant induction of HLA class I and class II molecules, pointing to a causal link between TIS and leukemia immunogenicity. Consistently, senescence-competent AML samples activated autologous CD4+ and CD8+ T cells and improved leukemia recognition by both T-cell subsets. Lastly, the anti-leukemic activity of Immune Checkpoint Blockades (ICBs) was enhanced upon senescence engagement in AML. Altogether, our results identify senescence as a potent immune-related anti-leukemic mechanism that may rapidly translate into innovative senescence-based strategies to prevent AML relapse
L'influence de la propension à schématiser par marques sur une stratégie d 'alliance marque/label écologique
La stratĂ©gie dâalliance dâune marque et dâun label est de plus en plus rĂ©pandue, mais celle-ci est coĂ»teuse pour les entreprises qui doivent pouvoir sâassurer de son efficacitĂ©. Pour accroĂźtre les connaissances sur lâalliance marque/label, nous avons Ă©tudiĂ© lâinfluence de la schĂ©matisation par marques sur lâimage dâun produit et lâintention dâachat. Les rĂ©sultats montrent que la schĂ©matisation par marques modĂšre lâinfluence de lâalliance marque/label Ă©cologique sur lâĂ©valuation des attributs produit et lâintention dâachat pour une catĂ©gorie de produit ayant une bonne congruence produit/label. En effet, la stratĂ©gie dâalliance marque/label aura un effet positif sur lâĂ©valuation des attributs du produit pour les individus qui schĂ©matisent peu. La schĂ©matisation par marques aura une influence positive sur lâintention dâachat quel que soit le produit prĂ©sentĂ© (avec ou sans alliance marque/label)
- âŠ