13,509 research outputs found
Conceptual Unification of Gravity and Quanta
We present a model unifying general relativity and quantum mechanics. The
model is based on the (noncommutative) algebra \mbox{{\cal A}} on the groupoid
\Gamma = E \times G where E is the total space of the frame bundle over
spacetime, and G the Lorentz group. The differential geometry, based on
derivations of \mbox{{\cal A}}, is constructed. The eigenvalue equation for the
Einstein operator plays the role of the generalized Einstein's equation. The
algebra \mbox{{\cal A}}, when suitably represented in a bundle of Hilbert
spaces, is a von Neumann algebra \mathcal{M} of random operators representing
the quantum sector of the model. The Tomita-Takesaki theorem allows us to
define the dynamics of random operators which depends on the state \phi . The
same state defines the noncommutative probability measure (in the sense of
Voiculescu's free probability theory). Moreover, the state \phi satisfies the
Kubo-Martin-Schwinger (KMS) condition, and can be interpreted as describing a
generalized equilibrium state. By suitably averaging elements of the algebra
\mbox{{\cal A}}, one recovers the standard geometry of spacetime. We show that
any act of measurement, performed at a given spacetime point, makes the model
to collapse to the standard quantum mechanics (on the group G). As an example
we compute the noncommutative version of the closed Friedman world model.
Generalized eigenvalues of the Einstein operator produce the correct components
of the energy-momentum tensor. Dynamics of random operators does not ``feel''
singularities.Comment: 28 LaTex pages. Substantially enlarged version. Improved definition
of generalized Einstein's field equation
Plasmid Injection and Application of Electric Pulses Alter Endogenous mRNA and Protein Expression in B16.F10 Mouse Melanomas
The application of electric pulses to tissues causes cell membrane destabilization, allowing exogenous molecules to enter the cells. This delivery technique can be used for plasmid gene therapy. Reporter gene expression after plasmid delivery with eight representative published protocols was compared in B16.F10 mouse melanoma tumors. This expression varied significantly based on the pulse parameters utilized for delivery. To observe the possible influence of plasmid injection and/or pulse application on endogenous gene expression, levels of stress-related mRNAs 4 and 24 h after delivery were determined by PCR array. Increases in mRNA levels for several inflammatory chemokines and cytokines were observed in response to plasmid injection, electric pulses alone or the combination. This upregulation was confirmed by individual real-time reverse transcription TaqMan PCR assays. Proteins were extracted at the same time points from identically treated tumors and inflammatory protein levels were assayed by enzyme-linked immunosorbent assay and by a custom multiplex bead array. Increases in inflammatory protein levels generally paralleled mRNA levels. Some differences were observed, which may have been due to differing expression kinetics. The observed upregulated expression of these cytokines and chemokines may aid or inhibit the therapeutic effectiveness of immune-based cancer gene therapies
The use of multispectral sensing techniques to detect ponderosa pine trees under stress from insect or pathogenic organisms
Application of multispectral sensors to detect insect and disease infestation of ponderosa pine tree
Semileptonic Decays of Heavy Mesons with the Fat Clover Action
We are studying a variety of semileptonic decays of heavy-light mesons in an
effort to improve the determination of the heavy-quark Standard-Model CKM
matrix elements. Our fermion action is a novel, improved ``fat'' clover action
that promises to reduce problems with exceptional configurations. Dynamical sea
quarks are included in a mixed approach, i.e. we use staggered sea quarks and
fat-clover valence quarks. Here we report preliminary results.Comment: LATTICE99(heavyqk) - 3p, 4 Postscript fig
The equation of state with nonzero chemical potential for 2+1 flavors
We present results for the QCD equation of state with nonzero chemical
potential using the Taylor expansion method with terms up to sixth order in the
expansion. Our calculations are performed on asqtad 2+1 quark flavor lattices
at .Comment: Talk given at the XXV International Symposium on Lattice Field
Theory, July 30-4 August 2007, Regensburg, German
Electrically Mediated Plasmid DNA Delivery to Hepatocellular Carcinomas in Vivo
Gene therapy by direct delivery of plasmid DNA has several advantages over viral gene transfer, but plasmid delivery is less efficient. In vivo electroporation has been used to enhance delivery of chemotherapeutic agents to tumors in both animal and human studies. Recently, this delivery technique has been extended to large molecules such as plasmid DNA. Here, the successful delivery of plasmids encoding reporter genes to rat hepatocellular carcinomas by in vivo electroporation is demonstrated
The locality of the fourth root of staggered fermion determinant in the interacting case
The fourth root approximation in LQCD simulations with dynamical staggered
fermions requires justification. We test its validity numerically in the
interacting theory in a renormalization group framework.Comment: 6 pages, Talk presented at Lattice 2005 (Machines and Algorithms
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