Business on television: continuity, change and risk in the development of television’s ‘business entertainment format’

This article traces the evolution of what has become known as the business entertainment format on British television. Drawing on interviews with channel controllers, commissioners and producers from across the BBC, Channel 4 and the independent sector this research highlights a number of key individuals who have shaped the development of the business entertainment format and investigates some of the tensions that arise from combining entertainment values with more journalistic or educational approaches to factual television. While much work has looked at docusoaps and reality programming, this area of television output has remained largely unexamined by television scholars. The research argues that as the television industry has itself developed into a business, programme-makers have come to view themselves as [creative] entrepreneurs thus raising the issue of whether the development off-screen of a more commercial, competitive and entrepreneurial TV marketplace has impacted on the way the medium frames its onscreen engagement with business, entrepreneurship, risk and wealth creation

Dialoging A Successful Pedagogy for Embedded Tutors

Over the past three years, Rider University’s Student Success Center Writing Lab has implemented an embedded tutor program for composition courses. Tutors attend class, participate in class discussions, facilitate writing workshops in class, and hold drop-in hours for students (in addition to tutors’ Writing Lab hours). The Embedded Tutor (ET) program, facilitated by Jenny Scudder (who is also the Writing Lab Director), has been successful in helping students complete skills-based courses and connect to academic support services. Initial assessment of the ET program supports the inclusion of the tutor in a skills-based course. While an ET’s training is similar to a tutor who works solely in the Writing Lab, there are key additions that are vital to the tutors’—and the program’s—succesUniversity Writing Cente

Differential regulation of anti-inflammatory genes by p38 MAP kinase and MAP kinase kinase 6.

BackgroundConventional p38α inhibitors have limited efficacy in rheumatoid arthritis, possibly because p38 blockade suppresses the counter-regulatory mechanisms that limit inflammation. In contrast, targeting the upstream MAP kinase kinases, MKK3 and MKK6, partially maintains p38-mediated anti-inflammatory responses in bone marrow-derived macrophages (BMDM). In this study, we explored the mechanisms that preserve anti-inflammatory gene expression by evaluating differential regulation of IL-10 and p38-dependent anti-inflammatory genes in MKK3-/-, MKK6-/-, and p38 inhibitor-treated wildtype cells.MethodsBMDM from wild type (WT), MKK3-/-, and MKK6-/- mice were pre-treated with p38 inhibitor SB203580 (SB), JNK inhibitor SP600125 (SP), and/or ERK inhibitor PD98059 (PD) and stimulated with LPS. Supernatant protein levels were measured by multiplex bead immunoassay. mRNA expression was determined by qPCR and protein expression by Western blot analysis. De novo IL-10 mRNA synthesis was quantified in cells treated with ethynyl-uridine and LPS followed by reverse transcription and qPCR. mRNA half-life was measured in LPS-treated cells that were then incubated with actinomycin D ± SB203580.ResultsPre-treatment of WT BMDM with p38 inhibitor significantly reduced IL-10 production in the three groups, while ERK and JNK inhibitors had minimal effects. IL-10 production was significantly decreased in MKK3-/- BMDM compared with either WT or MKK6-/- cells. IL-10 mRNA expression was modestly reduced in MKK3-/- BMDM but was preserved in MKK6-/- cells compared with WT. De novo IL-10 mRNA synthesis was inhibited in MKK3-/- and p38 inhibitor pre-treated cells, but not MKK6-/- cells compared with WT. IL-10 mRNA half-life was markedly reduced in p38 inhibitor-treated WT cells while MKK-deficiency had minimal effect. DUSP1 mRNA levels were preserved in MKK-deficient cells but not in p38 inhibitor-treated WT cells. Tristetraprolin mRNA and protein levels were reduced in p38 inhibitor-treated WT cells compared with MKK6-/- cells.ConclusionUnlike p38-inhibition, the absence of MKK6 mostly preserves IL-10 and TTP protein expression in BMDM. MKK6-deficiency also spares DUSP1 and IL-1RA, which are key negative regulators of the inflammatory response. Together, these data suggest that MKK6 is a potential therapeutic target in RA

Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes.

c-Jun N-terminal kinase (JNK) contributes to metalloproteinase (MMP) gene expression and joint destruction in inflammatory arthritis. It is phosphorylated by at least two upstream kinases, the mitogen-activated protein kinase kinases (MEK) MKK4 and MKK7, which are, in turn, phosphorylated by MEK kinases (MEKKs). However, the MEKKs that are most relevant to JNK activation in synoviocytes have not been determined. These studies were designed to assess the hierarchy of upstream MEKKs, MEKK1, MEKK2, MEKK3, and transforming growth factor-beta activated kinase (TAK)1, in rheumatoid arthritis (RA). Using either small interfering RNA (siRNA) knockdown or knockout fibroblast-like synoviocytes (FLSs), MEKK1, MEKK2, or MEKK3 deficiency (either alone or in combination) had no effect on IL-1beta-stimulated phospho-JNK (P-JNK) induction or MMP expression. However, TAK1 deficiency significantly decreased P-JNK, P-MKK4 and P-MKK7 induction compared with scrambled control. TAK1 knockdown did not affect p38 activation. Kinase assays showed that TAK1 siRNA significantly suppressed JNK kinase function. In addition, MKK4 and MKK7 kinase activity were significantly decreased in TAK1 deficient FLSs. Electrophoretic mobility shift assays demonstrated a significant decrease in IL-1beta induced AP-1 activation due to TAK1 knockdown. Quantitative PCR showed that TAK1 deficiency significantly decreased IL-1beta-induced MMP3 gene expression and IL-6 protein expression. These results show that TAK1 is a critical pathway for IL-1beta-induced activation of JNK and JNK-regulated gene expression in FLSs. In contrast to other cell lineages, MEKK1, MEKK2, and MEKK3 did not contribute to JNK phosphorylation in FLSs. The data identify TAK1 as a pivotal upstream kinase and potential therapeutic target to modulate synoviocyte activation in RA

A META ANALYSIS OF CONTINGENT VALUES FOR GROUNDWATER QUALITY IN THE UNITED STATES

This paper provides an overview and a meta analysis of existing US contingent valuation studies of groundwater quality. Using 108 observations from 14 studies, core economic variables, risk variables, and elicitation effects are found to systematically influence groundwater values. Other research design features are also investigated.Resource /Energy Economics and Policy,

An Analysis of Training, Generalization, and Maintenance Effects of Enhanced Primary Care Triple P for Parents of Preschool-Age Children with Disruptive Behavior

A brief primary care intervention for parents of preschool-age children with disruptive behavior, Primary Care Triple P (PCTP), was assessed using a multiple probe design. PCTP teaches parents procedures such as praise, modeling, incidental teaching, differential rein-forcement, time-out, planned ignoring, least-to-most methods of prompting, and behavior management routines for noncompliance. Parents learn about causes of common behavior problems, goal-setting, and how to self-monitor their implementation, as well as their children's behavior change. The study examined if newly learned parenting skills would generalize from training to non-training settings, if generalized skills would result in corresponding decreases in child disruptive behavior in non-training settings, and if these decreases would generalize over time. The 4-session intervention was sequentially introduced within a multiple probe format to each of 9 families with a total of 10 children whose ages were between 3-to 7-years. Direct observation of parent-child interaction in the homes found PCTP to be associated with lower levels of child disruptive behavior in target training and various generalization settings. Parent report data also confirmed reductions in intensity and frequency of disruptive behavior, an increase in task-specific parental self-efficacy, improved scores on the Parent Experience Survey, and high levels of consumer satisfaction. However, no significant reductions in aversive parent behavior were shown, nor increases in parent management skills, although trends for both were in the predicted direction. Decreases in observed child disruptive behavior were maintained by most families in training and generalization settings at follow-up. Parent-reported changes in task-specific parental self-efficacy measured at post-intervention continued into follow-up, thus providing further support for the short-term durability of PCTP. Implications for the delivery of brief interventions to prevent conduct problems are discussed