14,229 research outputs found
Airborne Wind Shear Detection and Warning Systems. Second Combined Manufacturers' and Technologists' Conference, part 1
The Second Combined Manufacturers' and Technologists' Conference hosted jointly by NASA Langley (LaRC) and the Federal Aviation Administration (FAA) was held in Williamsburg, Virginia, on October 18 to 20, 1988. The purpose of the meeting was to transfer significant, ongoing results gained during the second year of the joint NASA/FAA Airborne Wind Shear Program to the technical industry and to pose problems of current concern to the combined group. It also provided a forum for manufacturers to review forward-look technology concepts and for technologists to gain an understanding of the problems encountered by the manufacturers during the development of airborne equipment and the FAA certification requirements
Airborne Wind Shear Detection and Warning Systems: First Combined Manufacturers' and Technologists' Conference
The purpose of the meeting was to transfer significant, ongoing results gained during the first year of the joint NASA/FAA Airborne Wind Shear Program to the technical industry and to pose problems of current concern to the combined group. It also provided a forum for manufacturers to review forward-looking technology concepts and for technologists to gain an understanding of FAA certification requirements and the problems encountered by the manufacturers during the development of airborne equipment
A Discontinuity in the Distribution of Fixed Point Sums
The quantity , defined as the number of permutations of the set
whose fixed points sum to , shows a sharp discontinuity
in the neighborhood of . We explain this discontinuity and study the
possible existence of other discontinuities in for permutations. We
generalize our results to other families of structures that exhibit the same
kind of discontinuities, by studying when ``fixed points'' is replaced
by ``components of size 1'' in a suitable graph of the structure. Among the
objects considered are permutations, all functions and set partitions.Comment: 1 figur
Propagating mode-I fracture in amorphous materials using the continuous random network (CRN) model
We study propagating mode-I fracture in two dimensional amorphous materials
using atomistic simulations. We used the continuous random network (CRN) model
of an amorphous material, creating samples using a two dimensional analogue of
the WWW (Wooten, Winer & Weaire) Monte-Carlo algorithm. For modeling fracture,
molecular-dynamics simulations were run on the resulting samples. The results
of our simulations reproduce the main experimental features. In addition to
achieving a steady-state crack under a constant driving displacement (which had
not yet been achieved by other atomistic models for amorphous materials), the
runs show micro-branching, which increases with driving, transitioning to
macro-branching for the largest drivings. Beside the qualitative visual
similarity of the simulated cracks to experiment, the simulation also succeeds
in explaining the experimentally observed oscillations of the crack velocity
Front Propagation up a Reaction Rate Gradient
We expand on a previous study of fronts in finite particle number
reaction-diffusion systems in the presence of a reaction rate gradient in the
direction of the front motion. We study the system via reaction-diffusion
equations, using the expedient of a cutoff in the reaction rate below some
critical density to capture the essential role of fl uctuations in the system.
For large density, the velocity is large, which allows for an approximate
analytic treatment. We derive an analytic approximation for the front velocity
depe ndence on bulk particle density, showing that the velocity indeed diverge
s in the infinite density limit. The form in which diffusion is impleme nted,
namely nearest-neighbor hopping on a lattice, is seen to have an essential
impact on the nature of the divergence
Association between MAPT polymorphism but not APOE promoter and elite rugby athlete status
INTRODUCTION: Incidence and outcomes of concussions have been hypothesised to be genetically influenced. The APOE Promoter G219T (rs405509) polymorphism has been associated with differential promoter activity and unfavourable outcomes after traumatic brain injury. The TT genotype is associated with a 3-fold greater risk of multiple concussions. The TT genotype of MAPT (rs10445337) has also been associated with poorer outcomes after concussion. Rugby has one of the highest incidences of concussion in sport, so it was hypothesised that APOE Promoter TT and MAPT TT genotypes would be less prevalent in elite rugby athletes because those genotypes, previously associated with increased risk, would be less compatible with achieving elite athlete status. METHODS: Participants were from the RugbyGene project, comprising elite Caucasian male rugby athletes (n = 528; mean (standard deviation) height 1.85 (0.07) m, mass 101 (14) kg, age 29 (7) yr), including 420 rugby union (RU) athletes that for some analyses were divided into forwards and backs and 108 rugby league (RL) athletes. Non-athletes were 592 Caucasian men and women (57% male, height 1.72 (0.10) m, mass 74 (14) kg, age 31 (7) yr). PCR of genomic DNA was used to determine genotypes using TaqMan probes, then groups were compared using χ2 and odds ratio (OR) statistics. RESULTS: All genotype data were in Hardy-Weinberg equilibrium. For MAPT (rs10445337), the risk genotype (TT) was underrepresented in rugby athletes (60%) compared to non-athletes (66%), CT more common in rugby athletes (34%) than non-athletes (29%) and little difference in CC genotype frequencies (χ2 = 7.092, P = 0.029; TT genotype frequency OR = 0.80, 95% confidence intervals (CI) = 0.62-1.02). There were no differences in MAPT (rs10445337) genotype frequencies between RU forwards and backs. For APOE Promoter G219T (rs405509), there were no differences in genotype frequencies between all athletes (RU and RL) and non-athletes (27% TT genotype in players and non-athletes), nor between RU forwards and backs. CONCLUSION: The MAPT (rs10445337) TT genotype is 6% less common in elite rugby athletes than non-athletes. Therefore, carrying at least one rs10445337 C allele appears to increase the probability of sustained career success in the high-risk concussion environment of elite rugby, perhaps via a greater ability to recover from concussions.Peer reviewe
Association of MMP3 but not TIMP2 gene variants with elite rugby player status and rugby code
Introduction: Achilles tendon pathology and anterior cruciate ligament rupture are multifactorial conditions for which genetic risk factors have been identified. Single nucleotide polymorphisms (SNPs) within the MMP3 (rs591058, rs679620, rs650108) and TIMP2 (rs4789932) genes have previously been associated with tendon and ligament pathologies. Although not entirely clear, prior literature indicates the risk alleles for Achilles tendon pathology as T (rs591058), G (rs679620) and A (rs650108) for MMP3. However, prior evidence regarding TIMP2 is equivocal. MMP3 is considered an essential regulator of matrix degradation and remodelling within diseased and normal musculoskeletal soft tissues. TIMP2 maintains homeostasis in the extracellular matrix in part by inhibiting MMP function. Given the high incidence and severity of tendon and ligament injuries in elite rugby athletes, we hypothesised that the aforementioned SNPs would be associated with career success. Methods: Participants from the RugbyGene project were elite Caucasian male rugby athletes (n = 566; mean (standard deviation) height 1.85 (0.07) m, mass 101 (14) kg, age 29 (7) yr), including 420 rugby union (RU) athletes that for some analyses were divided into forwards and backs and 120 rugby league (RL) athletes. Non-athletes were 589 Caucasian men and women (n = 589, 57% male, height 1.72 (0.10) m, mass 74 (14) kg, age 31 (7) yr). PCR of genomic DNA was used to determine genotypes using TaqMan probes, then groups were compared using Χ2 and odds ratio (OR) statistics. Results: As hypothesized, the MMP3 rs591058 risk genotype (TT) was less frequent in rugby athletes (28%) compared to non-athletes (33%) (Χ2 = 7.265, P = 0.026; OR = 1.18, 95% confidence intervals (CI) = 0.86-1.63). No differences were found for MMP3 rs679620, rs650108 or TIMP2 rs4789932 between rugby athletes and non-athletes. When RL athletes were compared to non-athletes, the risk genotype (TT) of MMP3 rs591058 was underrepresented in RL athletes (19%) compared to non-athletes (33%). The MMP3 rs679620 ‘protective’ allele (C) was more frequent in RL athletes (55%) compared to non-athletes (48%) (OR = 1.3, 95% CI = 0.98-1.74). However, for MMP3 rs650108 the ‘risk’ allele (A) was overrepresented in RL athletes (32%) compared to non-athletes (26%). There were no genotype differences for any gene variant between RU athletes and non-athletes. The ‘risk’ allele (T) of the MMP3 rs679629 polymorphism and the ‘protective’ allele (G) of the MMP3 rs650108 polymorphism were less common in RL (45%, 68%, respectively) than RU athletes (54%, 76%, respectively). Conclusion: We provide evidence for elite rugby athletes possessing a protective genetic profile regarding tendon and ligament injury risk. Notably, a less frequent rs591058 TT genotype in athletes suggests a lower risk of injury could therefore enhance career success in rugby. Furthermore, RL players appear to have differing genetic characteristics compared to their RU counterparts, which might reflect some differences in physiological demands between codes.Peer reviewedFinal Published versio
On the Efficient Calculation of a Linear Combination of Chi-Square Random Variables with an Application in Counting String Vacua
Linear combinations of chi square random variables occur in a wide range of
fields. Unfortunately, a closed, analytic expression for the pdf is not yet
known. As a first result of this work, an explicit analytic expression for the
density of the sum of two gamma random variables is derived. Then a
computationally efficient algorithm to numerically calculate the linear
combination of chi square random variables is developed. An explicit expression
for the error bound is obtained. The proposed technique is shown to be
computationally efficient, i.e. only polynomial in growth in the number of
terms compared to the exponential growth of most other methods. It provides a
vast improvement in accuracy and shows only logarithmic growth in the required
precision. In addition, it is applicable to a much greater number of terms and
currently the only way of computing the distribution for hundreds of terms. As
an application, the exponential dependence of the eigenvalue fluctuation
probability of a random matrix model for 4d supergravity with N scalar fields
is found to be of the asymptotic form exp(-0.35N).Comment: 21 pages, 19 figures. 3rd versio
Real-time renormalization group and cutoff scales in nonequilibrium applied to an arbitrary quantum dot in the Coulomb blockade regime
We apply the real-time renormalization group (RG) in nonequilibrium to an
arbitrary quantum dot in the Coulomb blockade regime. Within one-loop
RG-equations, we include self-consistently the kernel governing the dynamics of
the reduced density matrix of the dot. As a result, we find that relaxation and
dephasing rates generically cut off the RG flow. In addition, we include all
other cutoff scales defined by temperature, energy excitations, frequency, and
voltage. We apply the formalism to transport through single molecular magnets,
realized by the fully anisotropic Kondo model (with three different exchange
couplings J_x, J_y, and J_z) in a magnetic field h_z. We calculate the
differential conductance as function of bias voltage V and discuss a quantum
phase transition which can be tuned by changing the sign of J_x J_y J_z via the
anisotropy parameters. Finally, we calculate the noise S(Omega) at finite
frequency Omega for the isotropic Kondo model and find that the dephasing rate
determines the height of the shoulders in dS(\Omega)/d Omega near Omega=V.Comment: 16 pages, 7 figure
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