ADCP current measurements (75 kHz) during RV SONNE cruise SO292/2

Upper-ocean velocities along the cruise track of Sonne cruise SO292/2 were continuously collected by a vessel-mounted Teledyne RD Instruments 75 kHz Ocean Surveyor ADCP. The transducer was located at 6.0 m below the water line. The instrument was operated in narrowband mode with 8 m bins and a blanking distance of 8.0 m, while 100 bins were recorded using a pulse of 1.46 s. The ship's velocity was calculated from position fixes obtained by the Global Positioning System (GPS). Heading, pitch and roll data from the ship's gyro platforms and the navigation data were used by the data acquisition software VmDas internally to convert ADCP velocities into earth coordinates. Accuracy of the ADCP velocities mainly depends on the quality of the position fixes and the ship's heading data. Further errors stem from a misalignment of the transducer with the ship's centerline. Data post-processing included water track calibration of the misalignment angle (-0.14° +/- 1.3027°) and scale factor (1.0020 +/- 0.0274) of the Ocean Surveyor signal. The average interval was set to 120 s. Velocity quality flagging is based on following threshold criteria: abs(UC) or abs(VC) > 1.5 m/s, rms(UC_z) or rms(VC_z) > 0.3

ADCP current measurements (38 kHz) during RV SONNE cruise SO292/2

Upper-ocean velocities along the cruise track of Sonne cruise SO292/2 were continuously collected by a vessel-mounted Teledyne RD Instruments 38 kHz Ocean Surveyor ADCP. The transducer was located at 6.0 m below the water line. The instrument was operated in narrowband mode with 32 m bins and a blanking distance of 16.0 m, while 50 bins were recorded using a pulse of 2.92 s. Beam velocities as recorded by the data acquistion software VmDas were transformed to ship coordinates and after merging with the navigation and attitude data from the ship's gyro and Global Positioning systems into earth coordinates. The ship's velocity was calculated from position fixes obtained by the Global Positioning System (GPS). Accuracy of the ADCP velocities mainly depends on the quality of the position fixes and the ship's heading data. Further errors stem from a misalignment of the transducer with the ship's centerline. Data post-processing included water track calibration of the misalignment angle (-0.22° +/- 1.2887°) and scale factor (1.0040 +/- 0.0299) of the Ocean Surveyor signal. The average interval was set to 120 s. Velocity quality flagging is based on following threshold criteria: abs(UC) or abs(VC) > 1.5 m/s, rms(UC_z) or rms(VC_z) > 0.5

An Approach to Forecast Air Traffic Movements at Capacity-Constrained Airports

Due to steadily growing air traffic, airports need a means to evaluate the capability of their infrastructure to handle future air traffic movements. Sound forecasts are needed for fundraising, within lawsuits, and in order to avoid misplanning. The quality of current forecasts is often queried. Hence, this work introduces parts of a tool chain that derives future air traffic movements out of transport scenarios and compares them to the capacity of an airport. Five consecutive models within the chain yield future air traffic movements for one airport considering passenger demand, a forecast of aircraft movements, airline preferences and airport capacity

Targeting type-2 metabotropic glutamate receptors to protect vulnerable hippocampal neurons against ischemic damage

To examine whether metabotropic glutamate (mGlu) receptors have any role in mechanisms that shape neuronal vulnerability to ischemic damage, we used the 4-vessel occlusion (4-VO) model of transient global ischemia in rats. 4-VO in rats causes a selective death of pyramidal neurons in the hippocampal CA1 region, leaving neurons of the CA3 region relatively spared. We wondered whether changes in the expression of individual mGlu receptor subtypes selectively occur in the vulnerable CA1 region during the development of ischemic damage, and whether post-ischemic treatment with drugs targeting the selected receptor(s) affords neuroprotection

Effect of the Metabotropic Glutamate Receptor Type 5 Negative Allosteric Modulator Dipraglurant on Motor and Non-Motor Symptoms of Parkinson’s Disease

Parkinson’s disease (PD) patients suffer not only from the primary motor symptoms of the disease but also from a range of non-motor symptoms (NMS) that cause disability and low quality of life. Excessive glutamate activity in the basal ganglia resulting from degeneration of the nigrostriatal dopamine pathway has been implicated in the motor symptoms, NMS and dyskinesias in PD patients. In this study, we investigated the effects of a selective mGlu5 negative allosteric modulator (NAM), dipraglurant, in a rodent motor symptoms model of PD, but also in models of anxiety, depression and obsessive-compulsive disorder, all of which are among the most prevalent NMS symptoms. Dipraglurant is rapidly absorbed after oral administration, readily crosses the blood-brain barrier, and exhibits a high correlation between plasma concentration and efficacy in behavioral models. In vivo, dipraglurant dose-dependently reduced haloperidol-induced catalepsy, increased punished licks in the Vogel conflict-drinking model, decreased immobility time in the forced swim test, decreased the number of buried marbles in the marble-burying test, but had no effect on rotarod performance or locomotor activity. These findings suggest that dipraglurant may have benefits to address some of the highly problematic comorbid non-motor symptoms of PD, in addition to its antidyskinetic effect demonstrated in PD-LID patients