3 research outputs found
Formulation of a topical sun protection cream for people with albinism
The aim of this investigation was to design and develop a sun protection product for people with albinism that is affordable, applicable to their specific skin condition, and provide them with the maximum sun protection possible. To achieve the required Sun Protection Factor value of > 20, simple creams were combined with very fine inorganic oxides (zinc oxide and titanium dioxide) and organic sunscreen filters (2-ethylhexyl cinnamate and octyl methoxycinnamate). These combinations also ensured high UVA/UVB protection ratios. The physical stability and change in Sun Protection Factor were for products stored for 8 weeks at 25°C (60% RH) and 45°C (75% RH) were also determined. Hypoallergenic and physically stable product(s) were formulated with SPF values between 20 to 30 and UVA/UVB ratios above 0.8 by combining simple cream formulations with fine particle inorganic oxides and organic UV protection agents. This approach offered an opportunity to formulate broad-spectrum sunscreen products that met the needs of albinos.Keywords: sun protection cream, sun protection factor, albinismThe East and Central African Journal of Pharmaceutical Sciences Vol. 7(3) 2006: 60-6
Compounded laxative formulations for substituting phenolphthalein with sennosides A & B in solid dosage forms
Purpose: Following the discovery of the carcinogenicity of
phenolphthalein and the subsequent ban of this compound in several
countries this study was undertaken to develop compounded formulations
of laxative products containing the stimulant laxatives sennosides A
and B. Methods: DSC and HPLC analysis was used to determine the
compatibility of sennosides with commonly used excipients before
compounding capsules, tablets and effervescent tablets containing
sennosides A & B. The physical and chemical stability and release
properties of these dosage forms were determined for 12 weeks at
increased temperature and relative humidity. Results: Sennosides A
& B were compatible with a wide variety of powdered excipients.
However, these were incompatible with propyl paraben, sodium carbonate,
stearic acid, citric acid, PEG, and sugar derivatives such as lactose,
glucose and sorbitol when granulated with water. Not withstanding these
interactions, it was possible to compound simple capsule, tablet and
even an effervescent tablet formulations containing sennosides A &
B that complied with pharmacopeial specifications. However, all these
formulations were sensitive to moisture because when stored at
increased temperature and relative humidity, disintegration times
increased and dissolution rates decreased. Conclusion: Based on
compatibility and stability studies simple, stable and elegant solid
dosage forms containing sennosides A & B were compounded that can
be used to replace phenolphthalein in a variety of solid dosage forms