1,392 research outputs found
Design and Construction of Large Size Micromegas Chambers for the Upgrade of the ATLAS Muon Spectrometer
Large area Micromegas detectors will be employed for the first time in
high-energy physics experiments. A total surface of about of
the forward regions of the Muon Spectrometer of the ATLAS detector at LHC will
be equipped with 8-layer Micromegas modules. Each layer covers more than
for a total active area of . Together with
the small strip Thin Gap Chambers they will compose the two New Small Wheels,
which will replace the innermost stations of the ATLAS endcap muon tracking
system in the 2018/19 shutdown. In order to achieve a 15
transverse momentum resolution for muons, in addition to an
excellent intrinsic resolution, the mechanical precision of each plane of the
assembled module must be as good as along the precision
coordinate and perpendicular to the chamber. The design and
construction procedure of the Micromegas modules will be presented, as well as
the design for the assembly of modules onto the New Small Wheel. Emphasis will
be on the methods developed to achieve the challenging mechanical precision.
Measurements and simulations of deformations created on chamber prototypes as a
function of thermal gradients, internal stress (mesh tension and module
fixation on supports) and gas over-pressure were essential in the development
of the final design. During installation and operation all deformations and
relative misalignments will be monitored by an optical alignment system and
compensated in the tracking software
Evidence comes by replication, but needs differentiation: the reproducibility issue in science and its relevance for criminology
Preventing Child Behavior Problems in the Erlangen-Nuremberg Development and Prevention Study: Results from Preschool to Secondary School Age
A brief overview of the prevention part of the long-term Erlangen-Nuremberg Development and Prevention Study, which combines a prospective longitudinal and experimental design. Findings up to five years after intervention are reported. From a sample of 609 families with kindergarten children, subgroups participated in the universal prevention program EFFEKT (child social skills training, a parent training and a combination of both) or were assigned to equivalentcontrol groups. The short-term evaluation showed significant effects in mediating constructs (social problem solving and parenting behavior) and in educators’ ratings of children’s social behavior. In a follow-up after two to three years, school report cards showed fewer children with multiple behavior problems. In a further follow up after four to five years program children reported fewer externalizing and internalizing problems than the control group. There were no significant effects in the mothers’ reports on their children’s behavior. Most significant effect sizes ranged between d = 0.20 and d = 0.40. The findings suggest various positive long-term effects of the intervention. However, one need to be cautious with regard to over-generalizing the positive findings, because effect sizes vary over time and the positive findings could not be replicated in all investigated variables
IWH-Signalansatz: Das gegenwärtige Finanzkrisenpotential in ausgewählten Ländern Mittel- und Osteuropas und der Türkei
The steep increase of oil prices, general threats rooting from Iran’s nuclear program, and doubts about the future policy of important central banks recently caused more uncertainties of investors on international financial markets. This explains the higher volatility and the fall of indices on stock markets including those of some Central and East European countries. International investors could respond with adjustments of their portfolio and trigger off a financial crisis. On this background, the article studies the potential for a financial crises in the region mentioned. The analytical tool is the IWH signals approach. The study concludes that the risk of the outbreak of a financial crisis within the next 18 months is rather unrealistic in most countries. A stable economic policy, high real growth rates, a financial system already robust compared to earlier times of transition, and appropriate exchange rate arrangements protect the countries against speculative attacks and portfolio adjustments. When the composite indicator shows deterioration like in the Baltic countries, it turned out to be negligible. For the Slovak Republic and Slovenia, the composite indicator even improved. A closer look to individual indicators reveals still some problems in the banking sectors of the Czech Republic, Poland, and Hungary, however, without out major impact on the composite indicator. This general assessment does not apply to Romania, and, in particular, to Turkey. The composite indicator signals a significant increase of the risk potential for the next 18 months in both countries. There is a considerable need for sound policy action.
The impact of contextual family risks on prisoners' children's behavioural outcomes and the potential protective role of family functioning moderators.
Research suggests that children of prisoners have an increased risk for behavioural and emotional problems. However, in a resilience approach, one should expect heterogeneous outcomes and thus apply a contextualized perspective. As this is rarely acknowledged in empirical research, the present study sought to fill this gap using data from the Fragile Families and Child Wellbeing study on 801 children of imprisoned fathers. We explored the extent to which cumulative family risks measured during the first year of life (e.g., poverty and mental health problems) predicted behavioural outcomes at age 9 and whether potentially protective aspects of family functioning moderated the impact of these risk factors. Cumulative risk significantly predicted behavioural outcomes, but the associations were weak. No strong evidence of moderation was found. At low risk, mother-child closeness moderated behavioural outcomes. There was also some evidence of moderation by accumulated protective factors. Potential implications for policy and practice and challenges for further research are discussed.The authors would like to thank the Economic and Social Research Council for providing funding for this research, the organisers of the Fragile Families and Child Wellbeing Study Summer Data Workshop 2013 for their introduction to the dataset and Steve Lainé for his technical support.This is the final version. It first appeared from Taylor & Francis via http://dx.doi.org/10.1080/17405629.2015.105037
The learners' electronic portfolio system (E-Portfolio) as an element of the information enviroment for managing the educational process
This article is devoted to the methodological and practical approaches to developing and implementing the electronic portfolios for learners as part of the electronic educational environment for managing the learning process. Based on the modern model of education in the pedagogical university, as well as on the federal state standard, the main sections of the system of the students' electronic portfolio have been formulated, which describe the main educational, scientific and other achievements of the students. In addition, the functional capabilities of the software implementation of an example of the electronic portfolio, software architecture and the methodological approaches to working with the system have been substantiated. The application of the students' electronic portfolios allows us to quickly obtain the information about the status of the main parameters of student activities and to stimulate them in different areas of the activities
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Re-framing the Analysis: A 3-dimensional Perspective of Prisoners' Children's Well-being
This article highlights three dimensions to understanding children's well-being during and after parental imprisonment which have not been fully explored in current research. A consideration of ‘time’ reveals the importance of children's past experiences and their anticipated futures. A focus on ‘space’ highlights the impact of new or altered environmental dynamics. A study of ‘agency’ illuminates how children cope within structural, material and social confines which intensify vulnerability and dependency. This integrated perspective reveals important differences in individual children's experiences and commonalities in broader systemic and social constraints on prisoners’ children. The paper analyses data from a prospective longitudinal study of 35 prisoners’ children during and after their (step) father's imprisonment to illustrate the arguments
Aldosterone rapidly activates Src kinase in M-1 cells involving the mineralocorticoid receptor and HSP84
AbstractWe investigated the effect of aldosterone on Src kinase. In the kidney cell line, M-1 aldosterone leads to a >2-fold transient activation of Src kinase seen as early as 2 min after aldosterone administration. Maximal Src kinase activation was measured at an aldosterone concentration of 1 nM. In parallel to activation, autophosphorylation at Tyr-416 of Src kinase increased. Src kinase activation was blocked by spironolactone. Aldosterone led to increased association of Src with HSP84. Furthermore, rapamycin blocked aldosterone-induced Src activation. We conclude that Src activation by aldosterone is mediated through the mineralocorticoid receptor and HSP84
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