Health-related quality of life is related to COPD disease severity

BACKGROUND: The aim of this study was to evaluate the association between health-related quality of life (HRQL) and disease severity using lung function measures. METHODS: A survey was performed in subjects with COPD in Sweden. 168 subjects (70 women, mean age 64.3 years) completed the generic HRQL questionnaire, the Short Form 36 (SF-36), the disease-specific HRQL questionnaire; the St George's Respiratory Questionnaire (SGRQ), and the utility measure, the EQ-5D. The subjects were divided into four severity groups according to FEV(1 )per cent of predicted normal using two clinical guidelines: GOLD and BTS. Age, gender, smoking status and socio-economic group were regarded as confounders. RESULTS: The COPD severity grades affected the SGRQ Total scores, varying from 25 to 53 (GOLD p = 0.0005) and from 25 to 45 (BTS p = 0.0023). The scores for SF-36 Physical were significantly associated with COPD severity (GOLD p = 0.0059, BTS p = 0.032). No significant association were noticed for the SF-36, Mental Component Summary scores and COPD severity. Scores for EQ-5D VAS varied from 73 to 37 (GOLD I-IV p = 0.0001) and from 73 to 50 (BTS 0-III p = 0.0007). The SGRQ Total score was significant between age groups (p = 0.0047). No significant differences in HRQL with regard to gender, smoking status or socio-economic group were noticed. CONCLUSION: The results show that HRQL in COPD deteriorates with disease severity and with age. These data show a relationship between HRQL and disease severity obtained by lung function

A Computational Investigation of Ground Simulation for a Saloon Car

Automotive aerodynamics measurements and simulations now routinely use a moving ground and rotating wheels (MVG&RW), which is more representative of on-road conditions than the fixed ground-fixed wheel (FG&FW) alternative. This can be understood as a combination of three elements: (a) moving ground (MVG), (b) rotating front wheels (RWF) and (c) rotating rear wheels (RWR). The interaction of these elements with the flow field has been explored to date by mainly experimental means. This paper presents a mainly computational (CFD) investigation of the effect of RWF and RWR, in combination with MVG, on the flow field around a saloon vehicle. The influence of MVG&RW is presented both in terms of a combined change from a FG&FW baseline and the incremental effects seen by the addition of each element separately. For this vehicle, noticeable decrease in both drag and rear lift is shown when adding MVG&RW, whereas front lift shows little change. The same trends are seen in both CFD and experimental data. The addition of MVG alone increases both drag and front lift, whereas rear lift decreases significantly. The addition of RWF alone has little effect on the global results (aside from lift), whereas the addition of RWR alone decreases both drag and rear lift significantly. Combining the incremental changes produces values that align well to the MVG&RW case, with the exception of front lift. This shows similar trends to previously published work, both the noticeable drag decrease due to the addition of MVG&RW, and the contributions of the individual components

Characterization of a Pore-Forming Cytotoxin Expressed by Salmonella enterica Serovars Typhi and Paratyphi A

Cytolysin A (ClyA) is a pore-forming cytotoxic protein encoded by the clyA gene that has been characterized so far only in Escherichia coli. Using DNA sequence analysis and PCR, we established that clyA is conserved in the human-specific typhoid Salmonella enterica serovars Typhi and Paratyphi A and that the entire clyA gene locus is absent in many other S. enterica serovars, including Typhimurium. The gene products, designated ClyA(STy) and ClyA(SPa), show ≥90% amino acid identity to E. coli cytolysin A, ClyA(EC), and they are immunogenically related. The Salmonella proteins showed a pore-forming activity and are hence functional homologues to ClyA(EC). The chromosomal clyA(STy) gene locus was expressed at detectable levels in the serovar Typhi strains S2369/96 and S1112/97. Furthermore, in the serovar Typhi vaccine strain Ty21a, expression of clyA(STy) reached phenotypic levels, as detected on blood agar plates. The hemolytic phenotype was abolished by the introduction of an in-frame deletion in the clyA(STy) chromosomal locus of Ty21a. Transcomplementation of the mutant with a cloned clyA(STy) gene restored the hemolytic phenotype. To our knowledge, Ty21a is the first reported phenotypically hemolytic Salmonella strain in which the genetic determinant has been identified

Open Access

Hippocampal volumes in patients exposed to low-dose radiation to the basal brain. A case

French shore

french aThis French shore, which is nearly one-half of the whole coast-line of Newfoundland, extends, as has been mentioned before, from Cape St. John on the north-east to Cape Ray on the south-west . . .See cited quotationPRINTED ITEMG. M. Story MAR 1970JH 3/70Used I and SupUsed I and SupNot use