14 research outputs found
Effect of DNA repair deficiencies on the cytotoxicity of resveratrol
Numerous preclinical studies have shown that the
naturally-occurring polyphenol resveratrol may
produce health-beneficial effects in a variety of
disorders, including cancer, diabetes, Alzheimer, and
cardiovascular diseases. Resveratrol has entered
clinical trials for the prevention and treatment of
several of these disorders. This polyphenol is also
available in the market as a dietary supplement.
Experimental data have shown, however, that
resveratrol induces DNA damage in a variety of cells.
Here we review such evidence and evaluate the
cytotoxicity of resveratrol (MTT assay) in cells deficient
in several major DNA repair pathways (i.e.,
homologous recombination, non-homologous end
joining, base excision repair, nucleotide excision repair,
mismatch repair, and Fanconi anemia repair). Cells
deficient in base excision repair (EM9), nucleotide
excision repair (UV4 and UV5) and Fanconi Anemia
(KO40) were slightly hypersensitive to
resveratrol-induced cytotoxicity with respect to their
parental cells (AA8). Our results suggest that these
pathways may participate in the repair of the DNA
damage induced by resveratrol and that deficiencies in
these pathways may confer hypersensitivity to the
genotoxic activity of this dietary constituen
La expresión corporal como complemento del lenguaje verbal para una comunicación eficaz que favorece la integración social de las personas con discapacidad
Los temas de salud en los medios informativos: una perspectiva desde la Enfermería y otros profesionales sanitarios
Trabajadores pobres y pobreza en el trabajo: concepto y evolución de la pobreza en la oculación: el impacto de las últimas reformas legales
Secretaría de Estado de Investigación, Desarrollo e InnovaciónFondo Europeo de Desarrollo Regional (FEDER) de la Unión Europe