Skeletal muscle glucose, G-6-P, glycogen, lactate, and acetyl CoA content.

<p>Skeletal muscle glucose, glucose -6 phosphate (G-6-P), glycogen, lactate and acetyl CoA in skeletal muscle specific IL-6 knockout (IL-6 MKO) and littermate floxed controls (Control) mice at rest and after 10, 60 or 120 min of exercise. Values are given as mean ± SE; n = 9–10.</p

Respiratory Exchange Ratio (RER) in skeletal muscle specific IL-6 knockout (IL-6 MKO) and littermate floxed controls (Control) during 120 min of metabolic treadmill exercise.

<p>Values are given as mean ± SE for every 10 minutes of continuous measurements; n = 5–7. *: significantly different from 10 min within given genotype, P<0.05. #: significantly different from control within given time point, P<0.05.</p

PDHa activity in skeletal muscle from skeletal muscle specific IL-6 knockout (IL-6 MKO) and littermate floxed controls (Control) at rest and after 10, 60 or 120 min of exercise.

<p>Values are given as mean ± SE; n = 10. *: significantly different from rest within given genotype, P<0.05. #: significantly different from control within given time point, P<0.05.</p

Lack of Skeletal Muscle IL-6 Affects Pyruvate Dehydrogenase Activity at Rest and during Prolonged Exercise - Fig 3

<p><b>A)</b> AMP-activated protein kinase (AMPK) Thr172 phosphorylation and <b>B)</b> Acetyl-CoA carboxylase 2 (ACC2) phosphorylation in skeletal muscle from skeletal muscle specific IL-6 knockout (IL-6 MKO) and littermate floxed controls (Control) mice at rest and after 10, 60 or 120 min of exercise. Values are given as mean ± SE; n = 9–10. Phosphorylation levels are given in arbitrary units (AU). *: significantly different from rest within given genotype, P<0.05. #: significantly different from control within given time point, P<0.05. (*): Tendency to be significantly different from rest within given genotype, 0.05</p

Skeletal muscle IL-6 regulates muscle substrate utilization and adipose tissue metabolism during recovery from an acute bout of exercise - Table 3

<p>Skeletal muscle IL-6 regulates muscle substrate utilization and adipose tissue metabolism during recovery from an acute bout of exercise</p> - Table

Skeletal muscle glycogen concentration (a), glucose concentration (b), glucose 6 phosphate (G6P) concentration (c) and lactate concentration (d) in non-exercised mice as well as 6h or 10h after 2h of treadmill running in Control and IL-6 MKO mice.

<p>Values are mean ± SE; (n = 9–10). *: significantly different from non-exercised within given genotype (p<0.05), ¤: significantly different from 6h within given genotype (p<0.05).</p

iWAT SOCS3 mRNA content (a) eWAT SOCS3 mRNA content (b) iWAT UCP1 mRNA content (c) eWAT UCP1 mRNA content (d) in non-exercised mice as well as 6h and 10h after 2h of treadmill running in Control and IL-6 MKO mice.

<p>Values are mean ± SE; (n = 9–10). *: significantly different from non-exercised within given genotype (p<0.05), ¤: significantly different from 6h within given genotype (p<0.05), #: significantly different from Control within given time point (p<0.05).</p

Skeletal muscle IL-6 regulates muscle substrate utilization and adipose tissue metabolism during recovery from an acute bout of exercise - Table 5

<p>Skeletal muscle IL-6 regulates muscle substrate utilization and adipose tissue metabolism during recovery from an acute bout of exercise</p> - Table

PDHa activity (a), PDH^Ser300 phosphorylation (b) PDK4 protein content (c), ACC^Ser212 phosphorylation (d) protein content representative blots of, PDH^Ser232 phosphorylation, PDH^Ser293 phosphorylation, PDH E1α, AMPK^Thr172 phosphorylation, AMPK (e) and HKII, GLUT4, LDHa protein content and ACC2 protein content (f).

<p>in non-exercised mice as well as 6h or 10h after 2h of treadmill running in IL-6 MKO and Control mice. Values are mean ± SE;(n = 9–10). *: significantly different from non-exercised within given genotype (p<0.05), ¤: significantly different from 6h within given genotype (p<0.05), #: significantly different from Control within given time point (p<0.05).</p

iWAT HSL^Ser660 phosphorylation (a), eWAT HSL^Ser660 phosphorylation (b), iWAT P38^Tyr180/182 phosphorylation (c), eWAT P38^Tyr180/182 phosphorylation (d), iWAT GLUT4 protein content (e), iWAT GLUT4 protein content (f), iWAT (g) and eWAT in non-exercised mice as well as 6h or 10h after 2h of treadmill running in d IL-6 MKO and Control mice.

<p>(h) Representative blots of HSL⁵⁶⁵ phosphorylation, HSL, UCP1 and P38 protein content. Values are mean ± SE; (n = 9–10). *: significantly different from non-exercised within given genotype (p<0.05), ¤: significantly different from 6h within given genotype (p<0.05), #: significantly different from Control within given time point (p<0.05).</p