Antitumor activity of lurbinectedin in second-line small cell lung cancer patients who are candidates for re-challenge with the first-line treatment

Introduction: The National Comprehensive Cancer Network guidelines recommend re-challenge with the first-line treatment for relapsed small cell lung cancer (SCLC) with chemotherapy-free interval (CTFI)=180 days. A phase II study (NCT02454972) showed remarkable antitumor activity in SCLC patients treated with lurbinectedin 3.2 mg/m2 1 -h intravenous infusion every 3 weeks as second-line therapy. We report results for the pre-planned subset of patients with CTFI = 180 days. Material and Methods: Twenty patients aged =18 years with pathologically proven SCLC diagnosis, pretreated with only one prior platinum-containing line, no CNS metastases, and with CTFI = 180 days were evaluated. The primary efficacy endpoint was the overall response rate (ORR) assessed by the Investigators according to RECIST v1.1. Results: ORR was 60.0 % (95 %CI, 36.1-86.9), with a median duration of response of 5.5 months (95 %CI, 2.9-11.2) and disease control rate of 95.0 % (95 %CI, 75.1-99.9). Median progression-free survival was 4.6 months (95 %CI, 2.6-7.3). With a censoring of 55.0 %, the median overall survival was 16.2 months (95 %CI, 9.6-upper level not reached). Of note, 60.9 % and 27.1 % of patients were alive at 1 and 2 years, respectively. The most common grade 3/4 adverse events and laboratory abnormalities were hematological disorders (neutropenia, 55.0 %; anemia; 10.0 % thrombocytopenia, 10.0 %), fatigue (10.0 %) and increased liver function tests (GGT, 10 %; ALT and AP, 5.0 % each). No febrile neutropenia was reported. Conclusion: Lurbinectedin is an effective treatment for platinum-sensitive relapsed SCLC, especially in patients with CTFI = 180 days, with acceptable safety and tolerability. These encouraging results suggest that lurbinectedin can be another valuable therapeutic option rather than platinum re-challenge

Evaluation of compost from seaweed and fish waste as a fertilizer for horticultural use

Composting may be an effective process for treating fish waste and drift seaweed to recover organic matter and nutrient resources and to produce fertilizers for organic agriculture. The aim of this study was to evaluate the use of this type of compost as a fertilizer in a horticultural crop rotation. A greenhouse trial was carried out to test the effects of the compost on a tomato crop and its residual effects on the succeeding lettuce crop. Different compost rates (C1, C2 and C3: 40 t ha(-1), 50 t ha(-1) and 66 t ha(-1)) were compared to single rates of a mineral fertilizer (M) and of a certified organic fertilizer made from dehydrated broiler litter (BL) as well as to the control treatment, which lacked fertilization (C). Tomato yield increased significantly (5.56 kg plant(-1)) with the highest rate of compost compared to the mineral and control treatments (4.54 and 4.58 kg plant(-1), respectively). This increased yield was associated with an increase in the diameter and weight of the fruits. Moreover, the lettuce yield improved with compost rates C2 (395 g lettuce(-1)) and C3 (367 g lettuce(-1)), showing a strong residual effect of the compost. This compost is suitable as organic soil fertilizer and may be recommended for improving horticultural crop yields.The authors acknowledge funding from Xunta de Galicia (Projects PGIDT05TAM097E and 09MRU016291PR and a post graduate grant for Marta Illera-Vives) and from Banco Santander (Mobility grant).info:eu-repo/semantics/publishedVersio