A Study on the Healthy Housing Quality of Multi-family Attached House According to Dwelling Unit Age

AbstractThe purpose of this study is to understand the healthy housing quality of four different multi-family attached house complexes that the constructions were finished at different years. In order to evaluate their healthy housing quality, the evaluation indicators of healthy housing, that have already existed, were used and the four complexes with different dwelling unit ages, located in Busan of Korea, were evaluated. For this, this study carry out residents’ evaluations of healthy housing quality through surveys on their satisfaction, and the study mainly identified characteristic according to dwelling unit age. According to the study, the health housing quality of multi-family attached house, of which the dwelling unit age is 10, begins to decrease in terms of managerial aspect. The healthy housing quality of social and managerial aspects is important for dwellers. The evaluation results can then be utilized to develop guidelines to manage and maintain healthy housing environments for apartments

Service Negotiation Model for Response Time in Distributed Networks

The important thing of QoS is that response time of service is transparently suggested to resource management system and network users. This helps to schedule jobs or guarantee the service level agreement. This paper proposes to specify a negotiation policy for response time of distributed network using network latency function. To monitor and manage service response time in distributed network, we identified the relationships between network/application performance and QoS parameters. We also provided the statistical analysis on mapping user level response time to application and network level parameters. To show the validation of the network latency function, we used the NS-2 network simulator and showed the efficiency of that function. Finally we suggested the negotiation of policy for response time of requested service

Selective uptake of epidermal growth factor-conjugated gold nanoparticle (EGF-GNP) facilitates non-thermal plasma (NTP)-mediated cell death

Non-thermal atmospheric pressure plasma (NTP) has been shown to induce cell death in various mammalian cancer cells. Accumulated evidence also shows that NTP could be clinically used in cancer therapy. However, the current NTP-based applications lack target specificity. Here, a novel method in NTP-mediated cancer therapeutics was described with enhanced target specificity by treating EGF (epidermal growth factor)-conjugated GNP (gold nanoparticle). The treatment with EGF-conjugated GNP complex, followed by NTP irradiation showed selective apoptosis of cells having receptor-mediated endocytosis. NTP triggered gamma-H2AX elevation which is a typical response elicited by DNA damage. These results suggest that EGF-conjugated GNP functions as an important adjuvant which gives target specificity in applications of conventional plasma therapy.111Ysciescopu

Heterogeneous nuclear ribonucleoprotein (hnRNP) L promotes DNA damage-induced cell apoptosis by enhancing the translation of p53

The tumor suppressor p53 is an essential gene in the induction of cell cycle arrest, DNA repair, and apoptosis. p53 protein is induced under cellular stress, blocking cell cycle progression and inducing DNA repair. Under DNA damage conditions, it has been reported that post-transcriptional regulation of p53 mRNA contributes to the increase in p53 protein level. Here we demonstrate that heterogeneous nuclear ribonucleoprotein (hnRNP) L enhances p53 mRNA translation. We found that hnRNP L is increased and binds to the 5' UTR of p53 mRNA in response to DNA damage. Increased hnRNP L caused enhancement of p53 mRNA translation. Conversely, p53 protein levels were decreased following hnRNP L knock-down, rendering them resistant to apoptosis and arrest in the G2/M phase after DNA damage. Thus, our findings suggest that hnRNP L functions as a positive regulator of p53 translation and promotes cell cycle arrest and apoptosis.11Ysciescopu

Genetic Structure of and Evidence for Admixture between Western and Korean Native Pig Breeds Revealed by Single Nucleotide Polymorphisms

Comprehensive information on genetic diversity and introgression is desirable for the design of rational breed improvement and conservation programs. Despite the concerns regarding the genetic introgression of Western pig breeds into the gene pool of the Korean native pig (KNP), the level of this admixture has not yet been quantified. In the present study, we genotyped 93 animals, representing four Western pig breeds and KNP, using the porcine SNP 60K BeadChip to assess their genetic diversity and to estimate the level of admixture among the breeds. Expected heterozygosity was the lowest in Berkshire (0.31) and highest in Landrace (0.42). Population differentiation (FST) estimates were significantly different (p<0.000), accounting for 27% of the variability among the breeds. The evidence of inbreeding observed in KNP (0.029) and Yorkshire (0.031) may result in deficient heterozygosity. Principal components one (PC1) and two (PC2) explained approximately 35.06% and 25.20% of the variation, respectively, and placed KNP somewhat proximal to the Western pig breeds (Berkshire and Landrace). When K = 2, KNP shared a substantial proportion of ancestry with Western breeds. Similarly, when K = 3, over 86% of the KNP individuals were in the same cluster with Berkshire and Landrace. The linkage disquilbrium (LD) values at r2 0.3, the physical distance at which LD decays below a threshold of 0.3, ranged from 72.40 kb in Landrace to 85.86 kb in Yorkshire. Based on our structure analysis, a substantial level of admixture between Western and Korean native pig breeds was observed

Combined epidural anesthesia and ultrasound guided peripheral nerve block for wound revision in a patient with peripartum cardiomyopathy -A case report-

Peripartum cardiomyopathy (PPCM) is a rare complication that occurs between the late stage of pregnancy and six months after delivery. PPCM presents as symptoms of left ventricular dysfunction and it can be fatal unless treated promptly. Furthermore, anesthesia and surgery in such patients is a large challenge to anesthesiologists. First and foremost, the maintenance of stable hemodynamics is a major concern. We report a case of combined lumbar epidural anesthesia and both ilioinguinal and iliohypogastric nerve block under ultrasound guided for a wound revision in a 37-year-old woman diagnosed with PPCM after an emergency cesarean section

The Quantitative Overhead Analysis for Effective Task Migration in Biosensor Networks

We present a quantitative overhead analysis for effective task migration in biosensor networks. A biosensor network is the key technology which can automatically provide accurate and specific parameters of a human in real time. Biosensor nodes are typically very small devices, so the use of computing resources is restricted. Due to the limitation of nodes, the biosensor network is vulnerable to an external attack against a system for exhausting system availability. Since biosensor nodes generally deal with sensitive and privacy data, their malfunction can bring unexpected damage to system. Therefore, we have to use a task migration process to avoid the malfunction of particular biosensor nodes. Also, it is essential to accurately analyze overhead to apply a proper migration process. In this paper, we calculated task processing time of nodes to analyze system overhead and compared the task processing time applied to a migration process and a general method. We focused on a cluster ratio and different processing time between biosensor nodes in our simulation environment. The results of performance evaluation show that task execution time is greatly influenced by a cluster ratio and different processing time of biosensor nodes. In the results, the proposed algorithm reduces total task execution time in a migration process

Detection of aquaporin-4 antibody using aquaporin-4 extracellular loop-based carbon nanotube biosensor for the diagnosis of neuromyelitis optica

Here we propose a carbon nanotube (CNT) field-effect transistor (FET) functionalized with aquaporin-4 (AQP4) extracellular loop peptides for the rapid detection of AQP4 antibody without pretreatment. Neuromyelitis optica (NMO) is a rare disease of the central nerve system that affects the optic nerves and the spinal cord. NMO-IgG, a serum antibody in patients, is highly specific for NMO and targets AQP4. We synthesized AQP4 extracellular loop peptides, known as primary autoimmune target in NMO, and immobilized them onto CNT-FET. The sensor showed p-type FET characteristics after the functionalization of peptides. The sensor was able to detect antibody with a detection limit of 1 ng l-1 . Moreover, AQP4 antibody in human serum was detected without any pretreatment. These results indicate that the biosensor can be used for rapid and simple detection of NMO antibody.OAIID:RECH_ACHV_DSTSH_NO:T201623708RECH_ACHV_FG:RR00200001ADJUST_YN:EMP_ID:A002014CITE_RATE:7.476FILENAME:1. (2016.04) Detection of aquaporin-4 antibody using aquaporin-4 extracellular.pdfDEPT_NM:화학생물공학부EMAIL:[email protected]_YN:YFILEURL:https://srnd.snu.ac.kr/eXrepEIR/fws/file/daebf249-842a-4b5c-bbc2-0b51d01edbb2/linkCONFIRM: