PSYDIAL: Personality-based Synthetic Dialogue Generation using Large Language Models

We present a novel end-to-end personality-based synthetic dialogue data generation pipeline, specifically designed to elicit responses from large language models via prompting. We design the prompts to generate more human-like dialogues considering real-world scenarios when users engage with chatbots. We introduce PSYDIAL, the first Korean dialogue dataset focused on personality-based dialogues, curated using our proposed pipeline. Notably, we focus on the Extraversion dimension of the Big Five personality model in our research. Experimental results indicate that while pre-trained models and those fine-tuned with a chit-chat dataset struggle to generate responses reflecting personality, models trained with PSYDIAL show significant improvements. The versatility of our pipeline extends beyond dialogue tasks, offering potential for other non-dialogue related applications. This research opens doors for more nuanced, personality-driven conversational AI in Korean and potentially other languages. Our code is publicly available at https://github.com/jiSilverH/psydial.Comment: LREC-COLING 2024 Mai

Activation of protease activated receptor 1 increases the excitability of the dentate granule neurons of hippocampus

Protease activated receptor-1 (PAR1) is expressed in multiple cell types in the CNS, with the most prominent expression in glial cells. PAR1 activation enhances excitatory synaptic transmission secondary to the release of glutamate from astrocytes following activation of astrocytically-expressed PAR1. In addition, PAR1 activation exacerbates neuronal damage in multiple in vivo models of brain injury in a manner that is dependent on NMDA receptors. In the hippocampal formation, PAR1 mRNA appears to be expressed by a subset of neurons, including granule cells in the dentate gyrus. In this study we investigate the role of PAR activation in controlling neuronal excitability of dentate granule cells. We confirm that PAR1 protein is expressed in neurons of the dentate cell body layer as well as in astrocytes throughout the dentate. Activation of PAR1 receptors by the selective peptide agonist TFLLR increased the intracellular Ca2+ concentration in a subset of acutely dissociated dentate neurons as well as non-neuronal cells. Bath application of TFLLR in acute hippocampal slices depolarized the dentate gyrus, including the hilar region in wild type but not in the PAR1-/- mice. PAR1 activation increased the frequency of action potential generation in a subset of dentate granule neurons; cells in which PAR1 activation triggered action potentials showed a significant depolarization. The activation of PAR1 by thrombin increased the amplitude of NMDA receptor-mediated component of EPSPs. These data suggest that activation of PAR1 during normal function or pathological conditions, such as during ischemia or hemorrhage, can increase the excitability of dentate granule cells

Breeding of Sweet Shinhong pepper by Marker-assisted backcrossing (MABC)

Capsinoids is unique compound of pepper, which have similar biological effect to apsaicinoids like anticancer and anti-obesity. However, because the characteristic of capsinoids is non-pungency contrary to capsaicinoids, it has been studied to investigate genetic factor related to biosynthesis of capsinoids and to breed pepper variety producing capsinoids. Two pathway are known to be involved in capsaicinoids synthesis, phenylpropanoid and valine pathway. Capsinoids biosynthesis pathway is common to capsaicinoids, but putative-aminotransferase (pAMT) gene mutation in phenylpropanoid pathway cause capsinoids production instead of capsaicinoids. SNU11-001 which have pAMT gene mutation produce high level of capsinoids and Shinhong is Korean chili pepper. In previous research, pAMT mutation in SNU11-001 have been introgressed to Shinhong to breed novel Shinhong pepper containing high contents of capsinoids by Marker-Assisted Backcrossing (MABC) method. Recessive homozygous pAMT allele was selected by genotyping with KASP marker for foreground selection and 8 to 10 plants which recovered by Shinhong genome highly were selected by Fluidigm high-throughput genotyping analysis. Shinhong C × SNU11-001 (SSHC) BC2F1-40 was selected by MABC with 198 SNP markers and recovery rate was 96.3%. In this study, MABC of SNU11-001 × Shinhong C (SSHC) BC3F1 and SNU11-001 × Shinhong B (SSHB) BC2F1 was proceeded. 202 and 102 markers were used for background selection, respectively. 10 SSHC BC3F1 progenies showed the highest recovery rate, 99.5%. The range of recovery rate in SSHB BC2F1 was 89.6 to 96.7%. SSHC BC2F2 was from self-crossing of SSHC BC2F1-40 and several pamt/pamt plants were selected. We will develop SSHB BC2F2 line which have pAMT mutation allele and high recovery rate of Shinhong B. This SSHB BC2F2 progeny will have cytoplasmic male sterility by being crossed with Shinhong A. Finally we will be able to breed sweet Shinhong F1 hybrid containing high level of capsinoids.OAIID:RECH_ACHV_DSTSH_NO:A201625343RECH_ACHV_FG:RR00200003ADJUST_YN:EMP_ID:A076900CITE_RATE:FILENAME:20161027_원예학회 포스터_장시영(ARC2-1).pdfDEPT_NM:식물생산과학부EMAIL:[email protected]_YN:FILEURL:https://srnd.snu.ac.kr/eXrepEIR/fws/file/e1d431a8-f997-43db-85e2-5ccb8e76020e/linkCONFIRM:

Dimeric configuration of SeqA protein bound to a pair of hemi-methylated GATC sequences

The binding of SeqA protein to hemi-methylated GATC sequences (hemi-sites) regulates chromosome initiation and the segregation of replicated chromosome in Escherichia coli. We have used atomic force microscopy to examine the architecture of SeqA and the mode of binding of one molecule of SeqA to a pair of hemi-sites in aqueous solution. SeqA has a bipartite structure composed of a large and a small lobe. Upon binding of a SeqA molecule to a pair of hemi-sites, the larger lobe becomes visibly separated into two DNA binding domains, each of which binds to one hemi-site. The two DNA binding domains are held together by association between the two multimerization domains that make up the smaller lobe. The binding of each DNA binding domain to a hemi-site leads to bending of the bound DNA inwards toward the bound protein. In this way, SeqA adopts a dimeric configuration when bound to a pair of hemi-sites. Mutational analysis of the multimerization domain indicates that, in addition to multimerization of SeqA polypeptides, this domain contributes to the ability of SeqA to bind to a pair of hemi-sites and to its cooperative behavior

Metastatic Thymoma of the Breast

Breast metastasis from nonmammary malignant neoplasms is uncommon, and it accounts for approximately 2% of all breast tumors. Distant metastasis of thymoma is very rare, and especially to extrathorcic areas. We report a female who had a metastatic thymoma in her breast 20 years after undergoing resection for a non-invasive thymoma. She presented with a palpable mass in her left breast. Mammography and ultrasonogram showed a lobular mass at the anterior glandular portion. Histological examination after surgical excision revealed a metastatic thymoma