334 research outputs found
Aggregation Scheduling Algorithms in Wireless Sensor Networks
In Wireless Sensor Networks which consist of tiny
wireless sensor nodes with limited battery power, one of the most
fundamental applications is data aggregation which collects nearby
environmental conditions and aggregates the data to a designated
destination, called a sink node. Important issues concerning the
data aggregation are time efficiency and energy consumption due
to its limited energy, and therefore, the related problem, named
Minimum Latency Aggregation Scheduling (MLAS), has been the
focus of many researchers. Its objective is to compute the minimum
latency schedule, that is, to compute a schedule with the minimum
number of timeslots, such that the sink node can receive the
aggregated data from all the other nodes without any collision or
interference. For the problem, the two interference models, the graph
model and the more realistic physical interference model known as
Signal-to-Interference-Noise-Ratio (SINR), have been adopted with
different power models, uniform-power and non-uniform power (with
power control or without power control), and different antenna
models, omni-directional antenna and directional antenna models.
In this survey article, as the problem has proven to be NP-hard,
we present and compare several state-of-the-art approximation
algorithms in various models on the basis of latency as its
performance measure
Smartphone Forensic Challenges
Article originally published in Internation Journal of Computer Science and SecurityGlobally, the extensive use of smartphone devices has led to an increase in storage and transmission of enormous volumes of data that could be potentially be used as digital evidence in a forensic investigation. Digital evidence can sometimes be difficult to extract from these devices given the various versions and models of smartphone devices in the market. Forensic analysis of smartphones to extract digital evidence can be carried out in many ways, however, prior knowledge of smartphone forensic tools is paramount to a successful forensic investigation. In this paper, the authors outline challenges, limitations and reliability issues faced when using smartphone device forensic tools and accompanied forensic techniques. The main objective of this paper is intended to be consciousness-raising than suggesting best practices to these forensic work challenges
Direct Preference-based Policy Optimization without Reward Modeling
Preference-based reinforcement learning (PbRL) is an approach that enables RL
agents to learn from preference, which is particularly useful when formulating
a reward function is challenging. Existing PbRL methods generally involve a
two-step procedure: they first learn a reward model based on given preference
data and then employ off-the-shelf reinforcement learning algorithms using the
learned reward model. However, obtaining an accurate reward model solely from
preference information, especially when the preference is from human teachers,
can be difficult. Instead, we propose a PbRL algorithm that directly learns
from preference without requiring any reward modeling. To achieve this, we
adopt a contrastive learning framework to design a novel policy scoring metric
that assigns a high score to policies that align with the given preferences. We
apply our algorithm to offline RL tasks with actual human preference labels and
show that our algorithm outperforms or is on par with the existing PbRL
methods. Notably, on high-dimensional control tasks, our algorithm surpasses
offline RL methods that learn with ground-truth reward information. Finally, we
show that our algorithm can be successfully applied to fine-tune large language
models.Comment: NeurIPS 202
Antiobesity and lipid-lowering effects of Bifidobacterium spp. in high fat diet-induced obese rats
<p>Abstract</p> <p>Background</p> <p>Recent studies have reported the preventive effects of probiotics on obesity. Among commensal bacteria, bifidobacteria is one of the most numerous probiotics in the mammalian gut and are a type of lactic acid bacteria. The aim of this study was to assess the antiobesity and lipid-lowering effects of <it>Bifidobacterium </it>spp. isolated from healthy Korean on high fat diet-induced obese rats.</p> <p>Methods</p> <p>Thirty-six male Sprague-Dawley rats were divided into three groups as follows: (1) SD group, fed standard diet; (2) HFD group, fed high fat diet; and (3) HFD-LAB group, fed high fat diet supplemented with LAB supplement (<it>B. pseudocatenulatum </it>SPM 1204, <it>B. longum </it>SPM 1205, and <it>B. longum </it>SPM 1207; 10<sup>8 </sup>~ 10<sup>9 </sup>CFU). After 7 weeks, the body, organ, and fat weights, food intake, blood serum levels, fecal LAB counts, and harmful enzyme activities were measured.</p> <p>Results</p> <p>Administration of LAB reduced body and fat weights, blood serum levels (TC, HDL-C, LDL-C, triglyceride, glucose, leptin, AST, ALT, and lipase levels), and harmful enzyme activities (β-glucosidase, β-glucuronidase, and tryptophanase), and significantly increased fecal LAB counts.</p> <p>Conclusion</p> <p>These data suggest that <it>Bifidobacterium </it>spp. used in this study may have beneficial antiobesity effects.</p
Neural responses to syllable-induced P1m and social impairment in children with autism spectrum disorder and typically developing Peers
In previous magnetoencephalography (MEG) studies, children with autism spectrum disorder (ASD) have been shown to respond differently to speech stimuli than typically developing (TD) children. Quantitative evaluation of this difference in responsiveness may support early diagnosis and intervention for ASD. The objective of this research is to investigate the relationship between syllable-induced P1m and social impairment in children with ASD and TD children. We analyzed 49 children with ASD aged 40–92 months and age-matched 26 TD children. We evaluated their social impairment by means of the Social Responsiveness Scale (SRS) and their intelligence ability using the Kaufman Assessment Battery for Children (K-ABC). Multiple regression analysis with SRS score as the dependent variable and syllable-induced P1m latency or intensity and intelligence ability as explanatory variables revealed that SRS score was associated with syllable-induced P1m latency in the left hemisphere only in the TD group and not in the ASD group. A second finding was that increased leftward-lateralization of intensity was correlated with higher SRS scores only in the ASD group. These results provide valuable insights but also highlight the intricate nature of neural mechanisms and their relationship with autistic traits
Molecular mechanisms of heptaplatin effective against cisplatin-resistant cancer cell lines: less involvement of metallothionein
BACKGROUND: Heptaplatin is a new platinum derivative with anticancer activity against various cancer cell lines, including cisplatin-resistant cancer cell lines (Cancer Chemother Pharmacol 1995; 35: 441). METHODS: Molecular mechanisms of heptaplatin effective against cisplatin-resistant cancer cell lines has been investigated in connection with metallothionein (MT). Cytotoxicity was determined by an MTT assay. MT mRNA, was determined by RT-PCR assay. Transfection study was carried out to examine the function of MT. RESULTS: Of various gastric cancer cell lines, SNU-638 and SNU-601 showed the highest and lowest levels of MT mRNA, respectively, showing 80-fold difference. The IC(50 )values of SNU-638 to cisplatin, carboplatin and heptaplatin were 11.2-fold, 5.1-fold and 2.0-fold greater than those of SNU-601, respectively. Heptaplatin was more effective against cisplatin-resistant and MT-transfected gastric cancer sublines than cisplatin or carboplatin was. In addition, heptaplatin attenuated cadmium, but not zinc, induction of MT. CONCLUSION: These results indicate that molecular mechanisms of heptaplatin effective against cisplatin-resistant gastric cancer sublines is at least in part due to the less involvement of MT in heptaplatin resistance as well as its attenuation of MT induction
Effect of Combination Therapy with Sodium Ozagrel and Panax Ginseng on Transient Cerebral Ischemia Model in Rats
Sodium ozagrel (SO) prevents platelet aggregation and vasoconstriction in the cerebral ischemia. It plays an important role in the prevention of brain damage induced by cerebral ischemia/reperfusion. Recently, many animal studies have suggested that the Panax ginseng (PG) has neuroprotective effects in the ischemic brain. In this study, we assessed the neuroprotective effects that come from a combination therapy of SO and PG in rat models with middle cerebral artery occlusion (MCAO). Animals with MCAO were assigned randomly to one of the following four groups: (1) control (Con) group, (2) SO group (3 mg/kg, intravenously), (3) PG group (200 mg/kg, oral feeding), and (4) SO + PG group. The rats were subjected to a neurobehavior test including adhesive removal test and rotarod test at 1, 3, 7, 10, and 15 days after MCAO. The cerebral ischemic volume was quantified by Metamorph imaging software after 2-3-5-triphenyltetrazolium (TTC) staining. The neuronal cell survival and astrocytes expansion were assessed by immunohistofluorescence staining. In the adhesive removal test, the rats of PG or SO + PG group showed significantly better performance than those of the control group (Con: 88.1 ± 24.8, PG: 43.6 ± 11, SO + PG: 11.8 ± 7, P < .05). Notably, the combination therapy group (SO + PG) showed better performance than the SO group alone (SO: 56 ± 12, SO + PG: 11.8 ± 7, P < .05). In TTC staining for infarct volume, cerebral ischemic areas were also significantly reduced in the PG group and SO + PG group (Con: 219 ± 32, PG: 117 ± 8, SO + PG: 99 ± 11, P < .05). Immunohistofluorescence staining results showed that the group which received SO + PG group therapy had neuron cells in the normal range. They also had a low number of astrocytes and apoptotic cells compared with the control or SO group in the peri-infarction area. During astrocytes staining, compared to the SO + PG group, the PG group showed only minor differences in the number of NeuN-positive cells and quantitative analysis of infarct volume. In conclusion, these studies showed that in MCAO rat models, the combination therapy with SO and PG may provide better neuroprotective effects such as higher neuronal cell survival and inhibition of astrocytes expansion than monotherapy with SO alone
Motor-Evoked Potential Confirmation of Functional Improvement by Transplanted Bone Marrow Mesenchymal Stem Cell in the Ischemic Rat Brain
This study investigated the effect of bone marrow mesenchymal stem cells (BMSCs) on the motor pathway in the transient ischemic rat brain that were transplanted through the carotid artery, measuring motor-evoked potential (MEP) in the four limbs muscle and the atlantooccipital membrane, which was elicited after monopolar and bipolar transcortical stimulation. After monopolar stimulation, the latency of MEP was significantly prolonged, and the amplitude was less reduced in the BMSC group in comparison with the control group (P < .05). MEPs induced by bipolar stimulation in the left forelimb could be measured in 40% of the BMSC group and the I wave that was not detected in the control group was also detected in 40% of the BMSC group. Our preliminary results imply that BMSCs transplanted to the ischemic rat brain mediate effects on the functional recovery of the cerebral motor cortex and the motor pathway
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