Spatial clustering of array CGH features in combination with hierarchical multiple testing

We propose a new approach for clustering DNA features using array CGH data from multiple tumor samples. We distinguish data-collapsing: joining contiguous DNA clones or probes with extremely similar data into regions, from clustering: joining contiguous, correlated regions based on a maximum likelihood principle. The model-based clustering algorithm accounts for the apparent spatial patterns in the data. We evaluate the randomness of the clustering result by a cluster stability score in combination with cross-validation. Moreover, we argue that the clustering really captures spatial genomic dependency by showing that coincidental clustering of independent regions is very unlikely. Using the region and cluster information, we combine testing of these for association with a clinical variable in an hierarchical multiple testing approach. This allows for interpreting the significance of both regions and clusters while controlling the Family-Wise Error Rate simultaneously. We prove that in the context of permutation tests and permutation-invariant clusters it is allowed to perform clustering and testing on the same data set. Our procedures are illustrated on two cancer data sets

Collaboration Management System between the Device based on Machine Socialization

The basis of IoT is in the interconnection and communication between different devices to achieve common goals through internet. These devices are interconnected through a network which enables communication within these devices without any direct human intervention. But with such great potential, this technology reached a road-block due to incompatibility within various manufacturers of the same type of device and proprietary standards. I started this project with this problem in mind and I have created a brand and platform independent machine socialization device manager system. In this paper, to overcome the above mentioned problem, I have utilized micro controllers to connect to various existing device to solve the problem and propose a device to device communication with collaboration management. This technology is not restricted to usage in only the new network module enabled smart devices but also this can be used to operate the existing old (not smart) home appliances. Machine socialization was made possible with the use of XML, (an internet standard schema language) which we have used to gather device, task and relationship information of all the devices to show schema information

Endoplasmic Reticulum Stress and Insulin Biosynthesis: A Review

Insulin resistance and pancreatic beta cell dysfunction are major contributors to the pathogenesis of diabetes. Various conditions play a role in the pathogenesis of pancreatic beta cell dysfunction and are correlated with endoplasmic reticulum (ER) stress. Pancreatic beta cells are susceptible to ER stress. Many studies have shown that increased ER stress induces pancreatic beta cell dysfunction and diabetes mellitus using genetic models of ER stress and by various stimuli. There are many reports indicating that ER stress plays an important role in the impairment of insulin biosynthesis, suggesting that reduction of ER stress could be a therapeutic target for diabetes. In this paper, we reviewed the relationship between ER stress and diabetes and how ER stress controls insulin biosynthesis

Electrogenic transport and K(+) ion channel expression by the human endolymphatic sac epithelium.

The endolymphatic sac (ES) is a cystic organ that is a part of the inner ear and is connected to the cochlea and vestibule. The ES is thought to be involved in inner ear ion homeostasis and fluid volume regulation for the maintenance of hearing and balance function. Many ion channels, transporters, and exchangers have been identified in the ES luminal epithelium, mainly in animal studies, but there has been no functional study investigating ion transport using human ES tissue. We designed the first functional experiments on electrogenic transport in human ES and investigated the contribution of K(+) channels in the electrogenic transport, which has been rarely identified, even in animal studies, using electrophysiological/pharmacological and molecular biological methods. As a result, we identified functional and molecular evidence for the essential participation of K(+) channels in the electrogenic transport of human ES epithelium. The identified K(+) channels involved in the electrogenic transport were KCNN2, KCNJ14, KCNK2, and KCNK6, and the K(+) transports via those channels are thought to play an important role in the maintenance of the unique ionic milieu of the inner ear fluid

Observation of photon-pair generation in the normal group-velocity-dispersion regime with slight detuning from the pump wavelength

A fiber-based photon-pair source in the telecom C-band is suitable for quantum information science including quantum communications. Spontaneous four-wave mixing effects are known to create photon pairs that are slightly detuned from the pump wavelength only in the anomalous group-velocity-dispersion (GVD) regime. Here, we achieve high-quality photon-pair generation slightly detuned from the pump wavelength in the normal GVD regime through a dispersion shifted fiber, for the first time. The photon pairs in C-band exhibit strong temporal correlation with each other and excellent heralded anti-bunching property. This photon-pair generation scheme can be exploited as telecom-band quantum light sources for quantum information applications.11Ysciescopu