Additional file 1: of Thyroid fine-needle aspiration biopsy positively correlates with increased diagnosis of thyroid cancer in South Korean patients

General characteristics of study population at baseline Provides a baseline characteristics of study population. (DOCX 16 kb

The regression analysis using with generalized equation estimating of outcome variable: Cesarean delivery, medical cost, length of stay.

<p>The regression analysis using with generalized equation estimating of outcome variable: Cesarean delivery, medical cost, length of stay.</p

General characteristics of participants and hospital.

<p>General characteristics of participants and hospital.</p

Differences in outcome variables between hospital type by Cesarean delivery and vaginal delivery.

<p>Data are shown as mean ± SD. All results are statistically significant by delivery type.</p

Subgroup analysis of outcome variable by age group.

<p>Subgroup analysis of outcome variable by age group.</p

The Association between Continuity of Care and All-Cause Mortality in Patients with Newly Diagnosed Obstructive Pulmonary Disease: A Population-Based Retrospective Cohort Study, 2005-2012

<div><p>Background</p><p>The disease burden is increasing for chronic obstructive pulmonary disease (COPD) due to increasing of the growth rate of prevalence and mortality. But the empirical researches are a little for COPD that studied the association between continuity of care and death and about predictors effect on mortality.</p><p>Objective</p><p>To investigate the association between continuity of care (COC) and chronic obstructive pulmonary disease (COPD) mortality and to identify other mortality-related factors in COPD patients.</p><p>Methods</p><p>We conducted a longitudinal, population-based retrospective cohort study in adult patients with COPD from 2002 to 2012 using a nationwide health insurance claims database. The study sample included individuals aged 40 years and over who developed COPD in 2005 and survived until 2006. We performed a Cox proportional hazard regression analysis with COC analyzed as a time-dependent covariate.</p><p>Results</p><p>Of the 3,090 participants, 60.8% died before the end of study (N = 1,879). The median years of survival for individuals with high COC (COC index≥0.75) was 3.92, and that for patients with low COC (COC index<0.75) was 2.58 in a Kaplan Meier analysis. In a multivariate, time-dependent analysis, low COC was associated with a 22% increased risk of all-cause mortality (HR, 1.22; 95% CI, 1.09–1.36). Not receiving oxygen therapy at home was associated with a 23% increased risk of all-cause mortality (HR, 1.23; 95% CI, 1.01–1.49). Moreover, the risk of all-cause mortality for individuals who admitted one time increased 38% (HR, 1.38; 95% CI, 1.21–1.59), two times was 63% (HR, 1.63; 95% CI, 1.34–1.99) and 3+ times was 96% (HR, 1.96; 95% CI, 1.63–2.36) relative to the reference group (no admission).</p><p>Conclusions</p><p>High COC was associated with a decreased risk of all-cause mortality. In addition, home oxygen therapy and number of hospital admissions may predict mortality in patients with COPD.</p></div

Median years of survival, stratified according to respiratory disability grade (n = 3,090).

<p>(E) Kaplan-Meier survival plot for patients with newly diagnosed COPD over 6 years of follow-up: Grade 1-Median 3.83 yrs; Grade 2-Median 4.50 yrs; Grade 3-Median 5.67 yrs; None-Median 3.17 yrs. (F) Adjusted Cox’s proportional hazards regression plot: Grade 1- Median 1.65 yrs; Grade 2-Median 2.17 yrs; Grade 3-Median 2.58 yrs; None-Median 4.25 yrs.</p

Additional file 1: of Association between residual teeth number in later life and incidence of dementia: A systematic review and meta-analysis

Supplement (DOCX 12 kb

Additional file 1: of Deregulation of sale of over-the-counter drugs outside of pharmacies in the Republic of Korea: interrupted-time-series analysis of outpatient visits before and after the policy

Table S1. Patients’ general characteristics (full model). Table S2. Mean number of monthly outpatient visits for acute upper respiratory infections, dyspepsia, and migraine (full model). Table S3. Interrupted time series analysis of the effect of the over-the-counter drug policy on number of monthly outpatient visits for acute upper respiratory infections, dyspepsia, and migraine (full model). (DOCX 80 kb

Median years of survival, stratified according to COC, which was treated as a time-dependent covariate (n = 3,090).

<p>(G) Plot for patients with newly diagnosed COPD over 6 years of follow-up using Breslow method; COC^† <0.75-Median 2.58 yrs; COC^† ≥0.75-Median 3.92 yrs. (H) Adjusted Cox’s proportional hazards regression plot: COC^† <0.75- Median 2.92 yrs; COC^† ≥0.75; Median 4.00 yrs. †, Continuity of care.</p