Alternative Agricultural Policies in Korea

Agricultural and Food Policy,

c-di-AMP: An essential molecule in the signaling pathways that regulate the viability and virulence of gram-positive bacteria

Signal transduction pathways enable organisms to monitor their external environment and adjust gene regulation to appropriately modify their cellular processes. Second messenger nucleotides including cyclic adenosine monophosphate (c-AMP), cyclic guanosine monophosphate (c-GMP), cyclic di-guanosine monophosphate (c-di-GMP), and cyclic di-adenosine monophosphate (c-di-AMP) play key roles in many signal transduction pathways used by prokaryotes and/or eukaryotes. Among the various second messenger nucleotides molecules, c-di-AMP was discovered recently and has since been shown to be involved in cell growth, survival, and regulation of virulence, primarily within Gram-positive bacteria. The cellular level of c-di-AMP is maintained by a family of c-di-AMP synthesizing enzymes, diadenylate cyclases (DACs), and degradation enzymes, phosphodiesterases (PDEs). Genetic manipulation of DACs and PDEs have demonstrated that alteration of c-di-AMP levels impacts both growth and virulence of microorganisms. Unlike other second messenger molecules, c-di-AMP is essential for growth in several bacterial species as many basic cellular functions are regulated by c-di-AMP including cell wall maintenance, potassium ion homeostasis, DNA damage repair, etc. c-di-AMP follows a typical second messenger signaling pathway, beginning with binding to receptor molecules to subsequent regulation of downstream cellular processes. While c-di-AMP binds to specific proteins that regulate pathways in bacterial cells, c-di-AMP also binds to regulatory RNA molecules that control potassium ion channel expression in Bacillus subtilis. c-di-AMP signaling also occurs in eukaryotes, as bacterially produced c-di-AMP stimulates host immune responses during infection through binding of innate immune surveillance proteins. Due to its existence in diverse microorganisms, its involvement in crucial cellular activities, and its stimulating activity in host immune responses, c-di-AMP signaling pathway has become an attractive antimicrobial drug target and therefore has been the focus of intensive study in several important pathogens

The move to independence from Anglican leadership: an examination of the relationship between Alexander Alfred Boddy and the early leaders of the British Pentecostal denominations (1907-1930)

This thesis examines the relationship between the leaders of the Anglican Church, centring on Alexander Alfred Boddy (1854-1930), considered the father of British Pentecostalism, and the young Pentecostals in the process of formation of the three major Pentecostal denominations, namely, the Apostolic Faith Church, the Assemblies of God and the Elim Church. Although there were not many Anglican participants in British Pentecostalism and most Pentecostals came from Nonconformist backgrounds, Boddy dominated the leadership from the beginning. As a result, most of the British Pentecostals who were actively involved in the forming of Pentecostal denominations were either directly or indirectly influenced by him. However, as Pentecostalism grew, disagreement and conflict appeared over certain issues and intensified during the period when the Pentecostal denominations were taking shape. Finally, with the departure of the Anglican leaders from Pentecostalism, the Anglican influence disappeared. Although there is no doubt that Boddy’s contribution to the history of British Pentecostalism was considerable, there were huge gaps between his teachings and those of the men who became the denominational leaders of the Pentecostals

On extensions of representations for compact Lie groups

Let $H$ be a closed normal subgroup of a compact Lie group $G$ such that $G/H$ is connected. This paper provides a necessary and sufficient condition for every complex representation of $H$ to be extendible to $G$, and also for every complex $G$-vector bundle over the homogeneous space $G/H$ to be trivial. In particular, we show that the condition holds when the fundamental group of $G/H$ is torsion free.Comment: 10 pages, AMS-LaTeX v1.